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The Immunological Barriers to Regenerative Medicine

  • Book
  • © 2013

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Editors:
  1. Paul J. Fairchild

    1. Oxford, United Kingdom

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  • Explores the extent to which the principles of allograft rejection, learned over several decades from our experiences of whole organ transplantation, apply within the unique context of cell replacement therapy
  • Discusses various innovative ways of addressing the issues of immunogenicity
  • Focuses exclusively on the induction of immunological tolerance through a variety of novel approaches
  • Includes supplementary material: sn.pub/extras

Part of the book series: Stem Cell Biology and Regenerative Medicine (STEMCELL)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xiii
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  2. The Immunogenicity of Stem Cells

    1. Front Matter

      Pages 1-1
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    2. Mechanisms of Immune Rejection of Stem Cell-Derived Tissues: Insights From Organ Transplantation

      • Eleanor M. Bolton, J. Andrew Bradley
      Pages 3-36

    3. The Immunogenicity of Embryonic Stem Cells and Their Differentiated Progeny

      • Jeremy I. Pearl, Joseph C. Wu
      Pages 37-48

    4. Interaction of Embryonic Stem Cells with the Immune System

      • Cody A. Koch, Jeffrey L. Platt
      Pages 49-67

    5. The Role of NK Cells and T Cells in the Rejection of Embryonic Stem Cell-Derived Tissues

      • Bob Miyake, Nicholas Zavazava
      Pages 69-76

    6. Mitigating the Risk of Immunogenicity in the Pursuit of Induced Pluripotency

      • Paul J. Fairchild, Naoki Ichiryu
      Pages 77-94

    7. Thymic Involution: A Barrier or Opportunity for Cell Replacement Therapy?

      • Simon Hackett, Paul J. Fairchild
      Pages 95-108

  3. Strategies for Overcoming Rejection of Stem Cell Grafts

    1. Front Matter

      Pages 109-109
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    2. Construction of Human Embryonic Stem Cell Banks: Prospects for Tissue Matching

      • Ge Lin, Qi Ou-Yang, Xiaobing Qian, Guangxiu Lu
      Pages 111-128

    3. Generation of Histocompatible Tissues via Parthenogenesis

      • Paula W. Lampton, Judith A. Newmark, Ann A. Kiessling
      Pages 129-146

    4. Prospects for Designing ‘Universal’ Stem Cell Lines

      • James C. Cicciarelli, Nathan A. Lemp, Noriyuki Kasahara
      Pages 147-173

    5. The Immunosuppressive Properties of Adult Stem Cells: Mesenchymal Stem Cells as a Case Study

      • Francesco Dazzi, Ilaria Marigo
      Pages 175-197

  4. Induction of Immunological Tolerance

    1. Front Matter

      Pages 199-199
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    2. The Immunogenicity of Stem Cells and Thymus-Based Strategies to Minimise Immune Rejection

      • Jessica Morison, Tracy Heng, Ann Chidgey, Richard Boyd
      Pages 201-223

    3. The Induction of Mixed Chimerism Using ES Cell-Derived Hematopoietic Stem Cells

      • Francesca Milanetti, You-Hong Cheng, Richard K. Burt
      Pages 225-255

    4. Prospects for the Induction of Transplant Tolerance Using Dendritic Cells

      • Matthew Buckland, Lesley Smyth, Robert Lechler, Giovanna Lombardi
      Pages 257-278

    5. Strategies for the Induction of Tolerance with Monoclonal Antibodies

      • Luis Graca
      Pages 279-295

    6. Induction of Immunological Tolerance to Transgene Products

      • Brandon K. Sack, David M. Markusic, Roland W. Herzog
      Pages 297-311

    7. Addressing the Challenge of Autoimmunity in the Treatment of Diabetes with Stem Cells

      • Karen English, Kathryn J. Wood
      Pages 313-329
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Keywords

About this book

This volume offers an analysis of the scale and nature of the immunological issues facing regenerative medicine, drawing on the expertise of laboratories around the world who have taken up the challenge of applying their expertise in immunology to the vagaries of stem cell biology. In Part I, we explore the extent to which the principles of allograft rejection, learned over several decades from our experiences of whole organ transplantation, apply within the unique context of cell replacement therapy. Part II discusses various innovative ways of addressing the issues of immunogenicity, while, in Part III, we focus exclusively on the induction of immunological tolerance through a variety of novel approaches. It is our hope that this systematic analysis of the current state of the field will galvanise efforts to solve an issue which has so far remained intractable.

Editors and Affiliations

  • Oxford, United Kingdom

    Paul J. Fairchild

About the editor

Dr. Paul Fairchild began his research career in Oxford, where he studied for a doctorate within the Nuffield Department of Surgical Sciences, where his research focused on the immune response to organ allografts.  After spending five years as a post-doctoral fellow investigating the etiology of autoimmune disease in the Department of Pathology, University of Cambridge, he returned to Oxford, where he is currently a University Lecturer in Pre-clinical Medicine within the Sir William Dunn School of Pathology and a Fellow of Trinity College.  In 2008, Paul Fairchild founded the Oxford Stem Cell Institute (OSCI), for which he currently serves as Co-Director.  As a highly interdisciplinary organization, the OSCI focuses on exploiting the properties of stem cells for the treatment of some of the most intractable chronic and degenerative diseases.  It is within this context that he continues to apply his background in transplantation immunology, in order to investigate the nature of the immune response to tissues differentiated from pluripotent stem cells, and develop approaches to the induction and maintenance of immunological tolerance.

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