Skip to main content
SpringerLink
Log in

Hematologic Neoplasms and Selected Tumor-Like Lesions Involving the Female Reproductive Organs

  • Living reference work entry
  • First Online:
Blaustein's Pathology of the Female Genital Tract

  • 232 Accesses

Abstract

A variety of hematologic neoplasms involves the female reproductive organs, including a number of different types of lymphomas and lymphoid leukemias, myeloid sarcomas and myeloid leukemias, and rarely histiocytic neoplasms. When the female reproductive organs are affected by one of these disorders in the setting of widespread disease, the diagnosis is usually straightforward, but in the uncommon instance in which the female genital tract is the presenting site of a hematologic neoplasm, diagnosis may be problematic, and special problems in differential diagnosis may arise.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Akakpo PK, Derkyi-Kwarteng L et al (2017) A pathological and clinical study of 706 primary tumours of the ovary in the largest tertiary hospital in Ghana. BMC Women’s Health 17(1):34

    Article  PubMed  PubMed Central  Google Scholar 

  • Alvarez A, Ortiz J et al (1997) Large B-cell lymphoma of the uterine corpus: case report with immunohistochemical and molecular study. Gynecol Oncol 65:534–538

    Article  PubMed  CAS  Google Scholar 

  • Axiotis C, Merino M et al (1991) Langerhans cell histiocytosis of the female genital tract. Cancer 67:1650–1660

    Article  PubMed  CAS  Google Scholar 

  • Barcos WL et al (1987) An autopsy study of 1206 acute and chronic leukemias (1958–1982). Cancer 60:827–837

    Article  PubMed  CAS  Google Scholar 

  • Bennett JA, Oliva E et al (2016) Primary endometrial marginal zone lymphoma (MALT lymphoma): a unique clinicopathologic entity. Am J Surg Pathol 40(9):1217–1223

    Article  PubMed  Google Scholar 

  • Brunning R, Matutes E et al (2001) Acute myeloid leukemia not otherwise categorised. In: Jaffe E, Harris N, Stein H, Vardiman J (eds) Pathology and genetics: tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon, pp 91–105

    Google Scholar 

  • Carbone A, Gloghini A et al (2006) A spindle cell variant of diffuse large B-cell lymphoma possesses genotypic and phenotypic markers characteristic of a germinal center B-cell origin. Mod Pathol 19(2):299–306

    Article  PubMed  CAS  Google Scholar 

  • Catlin EA, Roberts JD Jr et al (1999) Transplacental transmission of natural-killer-cell lymphoma. N Engl J Med 341(2):85–91

    Article  PubMed  CAS  Google Scholar 

  • Cecalupo AJ, Frankel LS et al (1982) Pelvic and ovarian extramedullary leukemic relapse in young girls. Cancer 50:587–593

    Article  PubMed  CAS  Google Scholar 

  • Chan JK, Loizzi V et al (2005) Clinicopathologic features of six cases of primary cervical lymphoma. Am J Obstet Gynecol 193(3 Pt 1):866–872

    Article  PubMed  Google Scholar 

  • Chandy L, Kumar L et al (1998) Non-Hodgkin’s lymphoma presenting as a primary lesion in uterine cervix: case report. J Obstet Gynaecol Res 24(3):183–187

    Article  PubMed  CAS  Google Scholar 

  • Chang JC, Blake DG et al (2013) Langerhans cell histiocytosis associated with lichen sclerosus of the vulva: case report and review of the literature. J Cutan Pathol 40(2):279–283

    Article  PubMed  Google Scholar 

  • Chen G, Crispin P et al (2016) Placental involvement by non-Hodgkin lymphoma in a Crohn disease patient on long-term thiopurine therapy. Intern Med J 46(1):102–105

    Article  PubMed  CAS  Google Scholar 

  • Chishima F, Hayakawa S et al (2006) Ovarian Burkitt’s lymphoma diagnosed by a combination of clinical features, morphology, immunophenotype, and molecular findings and successfully managed with surgery and chemotherapy. Int J Gynecol Cancer 16(Suppl 1):337–343

    Article  PubMed  Google Scholar 

  • Clemente N, Alessandrini L et al (2016) Primary non-Hodgkin’s lymphoma of the vulva: a case report and literature review. Medicine (Baltimore) 95(10):e3041

    Article  Google Scholar 

  • Cohn DE, Resnick KE et al (2007) Non-Hodgkin’s lymphoma mimicking gynecological malignancies of the vagina and cervix: a report of four cases. Int J Gynecol Cancer 17(1):274–279

    Article  PubMed  CAS  Google Scholar 

  • Cunningham I (2013) The clinical behavior of 124 leukemic ovarian tumors: clues for improving the poor prognosis. Leuk Lymphoma 54(7):1430–1436

    Article  PubMed  Google Scholar 

  • de Leval L, Ferry J et al (2001) Expression of bcl-6 and CD10 in primary mediastinal large cell lymphoma. Evidence for derivation from germinal center B cells? Am J Surg Pathol 25(10):1277–1282

    Article  PubMed  Google Scholar 

  • Dimopoulos MA, Daliani D et al (1997) Primary ovarian non-Hodgkin’s lymphoma: outcome after treatment with combination chemotherapy. Gynecol Oncol 64:446–450

    Article  PubMed  CAS  Google Scholar 

  • Ding J, Li H et al (2015) Ovarian granulocytic sarcoma as the primary manifestation of acute myelogenous leukemia. Int J Clin Exp Pathol 8(10):13552–13556

    PubMed  PubMed Central  CAS  Google Scholar 

  • Domingo S, Perales A et al (2004) Epstein-Barr virus positivity in primary vaginal lymphoma. Gynecol Oncol 95(3):719–721

    Article  PubMed  CAS  Google Scholar 

  • Drinkard LC, Waggoner S et al (1995) Acute myelomonocytic leukemia with abnormal eosinophils presenting as an ovarian mass: a report of two cases and a review of the literature. Gynecol Oncol 56:307–311

    Article  PubMed  CAS  Google Scholar 

  • Dursun P, Gultekin M et al (2005) Primary cervical lymphoma: report of two cases and review of the literature. Gynecol Oncol 98(3):484–489

    Article  PubMed  Google Scholar 

  • Ersahin C, Omeroglu G et al (2007) Myeloid sarcoma of the vulva as the presenting symptom in a patient with acute myeloid leukemia. Gynecol Oncol 106(1):259–261

    Article  PubMed  Google Scholar 

  • Ferry JA, Young RH (1991) Malignant lymphoma, pseudolymphoma and hematopoietic disorders of the female genital tract. Pathol Annu 26(Part 1):227–263

    PubMed  Google Scholar 

  • Ferry J, Young R (1997) Malignant lymphoma of the genitourinary tract. Curr Diagn Pathol 4:145–169

    Article  Google Scholar 

  • Ferry JA, Harris NL et al (1989) Leiomyomas with lymphoid infiltration simulating lymphoma. A report of 7 cases. Int J Gynecol Pathol 8:263–270

    Article  PubMed  CAS  Google Scholar 

  • Fratoni S, Abruzzese E et al (2016) Primitive “spindle cell variant” (sarcomatoid variant) diffuse large B-cell lymphoma of the uterine cervix: description and outcome of a rare case. Int J Gynecol Pathol 35(6):593–597

    Article  PubMed  Google Scholar 

  • Freeman C, Berg JW et al (1972) Occurrence and prognosis of extranodal lymphomas. Cancer 29(1):252–260

    Article  PubMed  CAS  Google Scholar 

  • Frey NV, Svoboda J et al (2006) Primary lymphomas of the cervix and uterus: the University of Pennsylvania's experience and a review of the literature. Leuk Lymphoma 47(9):1894–1901

    Article  PubMed  Google Scholar 

  • Gaffan J, Herbertson R et al (2004) Bilateral peripheral T-cell lymphoma of the fallopian tubes. Gynecol Oncol 95(3):736–738

    Article  PubMed  Google Scholar 

  • Garavaglia E, Taccagni G et al (2005) Primary stage I-IIE non-Hodgkin’s lymphoma of uterine cervix and upper vagina: evidence for a conservative approach in a study on three patients. Gynecol Oncol 97(1):214–218

    Article  PubMed  Google Scholar 

  • Garcia MG, Deavers MT et al (2006) Myeloid sarcoma involving the gynecologic tract: a report of 11 cases and review of the literature. Am J Clin Pathol 125(5):783–790

    Article  PubMed  Google Scholar 

  • Geyer JT, Ferry JA et al (2010) Florid reactive lymphoid hyperplasia of the lower female genital tract (lymphoma-like lesion): a benign condition that frequently harbors clonal immunoglobulin heavy chain gene rearrangements. Am J Surg Pathol 34(2):161–168

    Article  PubMed  Google Scholar 

  • Guvvala SL, Sakam S et al (2017) Case of primary bilateral diffuse large B-cell lymphoma of the ovary with plasmablastic features in an HIV-negative female patient. BMJ Case Rep 2017

    Google Scholar 

  • Hachisuga T, Ookuma Y et al (1992) Detection of Epstein-Barr virus DNA from a lymphoma-like lesion of the uterine cervix. Gynecol Oncol 46:69–73

    Article  PubMed  CAS  Google Scholar 

  • Hans CP, Weisenburger DD et al (2004) Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 103(1):275–282

    Article  PubMed  CAS  Google Scholar 

  • Harris NL, Scully RE (1984) Malignant lymphoma and granulocytic sarcoma of the uterus and vagina. A clinicopathologic analysis of 27 cases. Cancer 53:2530–2545

    Article  PubMed  CAS  Google Scholar 

  • Hernandez JA, Navarro JT et al (2002) Primary myeloid sarcoma of the gynecologic tract: a report of two cases progressing to acute myeloid leukemia. Leuk Lymphoma 43(11):2151–2153

    Article  PubMed  Google Scholar 

  • Horowitz NA, Benyamini N et al (2013) Reproductive organ involvement in non-Hodgkin lymphoma during pregnancy: a systematic review. Lancet Oncol 14(7):e275–e282

    Article  PubMed  Google Scholar 

  • Iliya FA, Muggia FM et al (1968) Gynecologic manifestations of reticulum cell sarcoma. Obstet Gynecol 31:266–269

    Article  PubMed  CAS  Google Scholar 

  • Imrie KR, Kovass MJ et al (1995) Isolated chloroma: the effect of early antileukemic therapy. Ann Inter Med 123(5):351–353

    Article  CAS  Google Scholar 

  • Issa PY, Salem PA et al (1980) Eosinophilic granuloma with involvement of the female genitalia. Am J Obstet Gynecol 137:608–612

    Article  PubMed  CAS  Google Scholar 

  • Iyengar P, Deodhare S (2004) Primary extranodal marginal zone B-cell lymphoma of MALT type of the endometrium. Gynecol Oncol 93(1):238–241

    Article  PubMed  Google Scholar 

  • Jackisch C, Louwen F et al (2003) Lung cancer during pregnancy involving the products of conception and a review of the literature. Arch Gynecol Obstet 268(2):69–77

    PubMed  Google Scholar 

  • Kahlifa M, Buckstein R et al (2003) Sarcomatoid variant of B-cell lymphoma of the uterine cervix. Int J Gynecol Pathol 22(3):289–293

    Article  PubMed  Google Scholar 

  • Kaplan MA, Jacobson JO et al (1993) T cell lymphoma of the vulva with erythrophagocytosis in a renal allograft recipient. Am J Surg Pathol 17:842–849

    Article  PubMed  CAS  Google Scholar 

  • Kaplan EJ, Chadburn A et al (1996) Case report. HIV-related primary non-Hodgkin’s lymphoma of the vulva. Gynecol Oncol 61:131–138

    Article  PubMed  CAS  Google Scholar 

  • Kawauchi S, Fukuma F et al (2002) Malignant lymphoma arising as a primary tumor of the uterine corpus. Pathol Int 52(5–6):423–424

    Article  PubMed  Google Scholar 

  • Kazi S, Szporn AH et al (2013) Recurrent precursor-B acute lymphoblastic leukemia presenting as a cervical malignancy. Int J Gynecol Pathol 32(2):234–237

    Article  PubMed  Google Scholar 

  • Kirk CM, Naumann RW et al (2001) Primary endometrial T-cell lymphoma. A case report. Am J Clin Pathol 115(4):561–566

    Article  PubMed  CAS  Google Scholar 

  • Kosari F, Daneshbod Y et al (2005) Lymphomas of the female genital tract: a study of 186 cases and review of the literature. Am J Surg Pathol 29(11):1512–1520

    Article  PubMed  Google Scholar 

  • Lagoo AS, Robboy SJ (2006) Lymphoma of the female genital tract: current status. Int J Gynecol Pathol 25(1):1–21

    Article  PubMed  Google Scholar 

  • Lanjewar D, Dongaonkar D (2006) HIV-associated primary non-Hodgkin's lymphoma of ovary: a case report. Gynecol Oncol 102(3):590–592

    Article  PubMed  CAS  Google Scholar 

  • Lee AC, Chui CH (2015) Bilateral ovarian Burkitt’s lymphoma: successful treatment with preservation of ovarian function. J Pediatr Adolesc Gynecol 28(4):e105–e107

    Article  PubMed  Google Scholar 

  • Leoncini L, Campo E, Stein H, Harris N, Jaffe E, Kluin P (2017) Burkitt lymphoma. In: Swerdlow S, Campo E, Harris N et al (eds) WHO classification of tumours of haematopoietic and lymphoid tissues. 4th, update ed. Lyon: IARC, pp 330–4

    Google Scholar 

  • Lieberman PH, Jones CR et al (1996) Langerhans cells (eosinophilic) granulomatosis. Am J Surg Pathol 20:519–552

    Article  PubMed  CAS  Google Scholar 

  • Liu PI, Ishimaru T et al (1973) Autopsy study of granulocytic sarcoma (chloroma) in patients with myelogenous leukemia, Hiroshima-Nagasaki 1949–1969. Cancer 31:948–955

    Article  PubMed  CAS  Google Scholar 

  • Lyman MD, Neuhauser TS (2002) Precursor T-cell acute lymphoblastic leukemia/lymphoma involving the uterine cervix, myometrium, endometrium, and appendix. Ann Diagn Pathol 6(2):125–128

    Article  PubMed  Google Scholar 

  • Ma J, Shi Q et al (2007) Lymphoma-like lesion of the uterine cervix: report of 12 cases of a rare entity. Int J Gynecol Pathol 26(2):194–198

    Article  PubMed  Google Scholar 

  • Macleod C, Palmer A et al (1998) Primary non-Hodgkin’s lymphoma of the vulva: a case report. Int J Gynecol Cancer 8:504–508

    Article  Google Scholar 

  • Magloire LK, Pettker CM et al (2006) Burkitt’s lymphoma of the ovary in pregnancy. Obstet Gynecol 108(3 Pt 2):743–745

    Article  PubMed  Google Scholar 

  • Maguire A, Castriciano G et al (2015) Case study: diffuse large B-cell lymphoma arising in ovarian mature cystic teratoma. Int J Gynecol Pathol 34(5):459–464

    Article  PubMed  Google Scholar 

  • Makarewicz R, Kuzminska A (1995) Non-Hodgkin’s lymphoma of the uterine cervix: a report of three patients. Clin Oncol (R Coll Radiol) 7:198–199

    Article  CAS  Google Scholar 

  • Mandato VD, Palermo R et al (2014) Primary diffuse large B-cell lymphoma of the uterus: case report and review. Anticancer Res 34(8):4377–4390

    PubMed  Google Scholar 

  • Mansouri H, Sifat H et al (2000) Primary malignant lymphoma of the ovary: an unusual presentation of a rare disease. Eur J Gynaec Oncol 21(6):616–618

    CAS  Google Scholar 

  • Maruko K, Maeda T et al (2004) Transplacental transmission of maternal B-cell lymphoma. Am J Obstet Gynecol 191(1):380–381

    Article  PubMed  Google Scholar 

  • McKelvey A, McKenna D et al (2003) A case of lymphoma occurring in an ovarian teratoma. Gynecol Oncol 90(2):474–477

    Article  PubMed  Google Scholar 

  • Meguerian-Bedoyan Z, Lamant L et al (1997) Anaplastic large cell lymphoma of maternal origin involving the placenta: case report and literature survey. Am J Surg Pathol 21(10):1236–1241

    Article  PubMed  CAS  Google Scholar 

  • Mehta N, Schoder H et al (2014) Adnexal mass secondary to extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with associated amyloid deposition. BMJ Case Rep 2014

    Google Scholar 

  • Meis JM, Butler JJ et al (1986) Granulocytic sarcoma in nonleukemic patients. Cancer 58:2697–2709

    Article  PubMed  CAS  Google Scholar 

  • Miyazaki N, Kobayashi Y et al (2013) Burkitt lymphoma of the ovary: a case report and literature review. J Obstet Gynaecol Res 39(8):1363–1366

    Article  PubMed  Google Scholar 

  • Montero AJ, Diaz-Montero CM et al (2003) Langerhans cell histiocytosis of the female genital tract: a literature review. Int J Gynecol Cancer 13(3):381–388

    Article  PubMed  CAS  Google Scholar 

  • Murase T, Inagaki H et al (2002) Nasal NK-cell lymphoma followed by relapse in the uterine cervix. Leuk Lymphoma 43(1):203–206

    Article  PubMed  Google Scholar 

  • Nagarsheth NP, Kalir T et al (2005) Post-transplant lymphoproliferative disorder of the cervix. Gynecol Oncol 97(1):271–275

    Article  PubMed  Google Scholar 

  • Nasioudis D, Kampaktsis PN et al (2017) Primary lymphoma of the female genital tract: an analysis of 697 cases. Gynecol Oncol 145(2):305–309

    Article  PubMed  Google Scholar 

  • Nasu K, Yoshimatsu J et al (1998) A case of primary non-Hodgkin’s lymphoma of the uterine cervix treated by combination chemotherapy (THP-COP). J Obstet Gynaecol Res 24(2):157–160

    Article  PubMed  CAS  Google Scholar 

  • Neiman RS, Barcos M et al (1981) Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases. Cancer 48:1426–1437

    Article  PubMed  CAS  Google Scholar 

  • Neuhauser TS, Tavassoli FA et al (2000) Follicle center lymphoma involving the female genital tract: a morphologic and molecular genetic study of three cases. Ann Diagn Pathol 4(5):293–299

    Article  PubMed  CAS  Google Scholar 

  • Nezhat CH, Dun EC et al (2013) A rare case of primary extranodal marginal zone B-cell lymphoma of the ovary, fallopian tube, and appendix in the setting of endometriosis. Am J Obstet Gynecol 208(1):e12–e14

    Article  PubMed  Google Scholar 

  • Nishi Y, Suzuki S et al (2000) B-cell-type malignant lymphoma with placental involvement. J Obstet Gynaecol Res 26(1):39–43

    Article  PubMed  CAS  Google Scholar 

  • Noack F, Lange K et al (2002) Primary extranodal marginal zone B-cell lymphoma of the fallopian tube. Gynecol Oncol 86(3):384–386

    Article  PubMed  Google Scholar 

  • Nomura S, Ishii K et al (2006) Burkitt lymphoma of the uterus in a human T lymphotropic virus type-1 carrier. Intern Med 45(4):215–217

    Article  PubMed  Google Scholar 

  • Nunes V, Della Starza I et al (2015) A case of late isolated ovarian relapse of acute lymphoblastic leukemia after an allogeneic stem cell transplant. Leuk Lymphoma 56(5):1517–1520

    Article  PubMed  Google Scholar 

  • Ohmori T, Wakamoto R et al (2002) Immunohistochemical study of a case of uterine leiomyoma showing massive lymphoid infiltration and localized vasculitis after LH-RH derivant treatment. Histopathology 41(3):276–277

    PubMed  CAS  Google Scholar 

  • Oliva E, Ferry JA et al (1997) Granulocytic sarcoma of the female genital tract. A clinicopathologic study of 11 cases. Am J Surg Pathol 21:1156–1165

    Article  PubMed  CAS  Google Scholar 

  • Osborne BM, Robboy SJ (1983) Lymphomas or leukemia presenting as ovarian tumors. An analysis of 42 cases. Cancer 52:1933–1943

    Article  PubMed  CAS  Google Scholar 

  • Ozsan N, Bedke BJ et al (2011) Clinicopathologic and genetic characterization of follicular lymphomas presenting in the ovary reveals 2 distinct subgroups. Am J Surg Pathol 35(11):1691–1699

    Article  PubMed  Google Scholar 

  • Padula A, Medeiros LJ et al (2004) Isolated vulvar Langerhans cell histiocytosis: report of two cases. Int J Gynecol Pathol 23(3):278–283

    Article  PubMed  Google Scholar 

  • Paik SS, Oh YH et al (2004) Uterine leiomyoma with massive lymphoid infiltration: case report and review of the literature. Pathol Int 54(5):343–348

    Article  PubMed  Google Scholar 

  • Pathak B, Bruchim I et al (2005) Granulocytic sarcoma presenting as tumors of the cervix. Gynecol Oncol 98(3):493–497

    Article  PubMed  Google Scholar 

  • Perren T, Farrant M et al (1992) Lymphomas of the cervix and upper vagina: a report of five cases and a review of the literature. Gynecol Oncol 44:87–95

    Article  PubMed  CAS  Google Scholar 

  • Prevot S, Hugol D et al (1992) Primary non Hodgkin’s malignant lymphoma of the vagina. Report of 3 cases with review of the literature. Path Res Pract 188:78–85

    Article  PubMed  CAS  Google Scholar 

  • Pullarkat V, Veliz L et al (2007) Therapy-related, mixed-lineage leukaemia translocation-positive, monoblastic myeloid sarcoma of the uterus. J Clin Pathol 60(5):562–564

    Article  PubMed  PubMed Central  Google Scholar 

  • Ragupathy K, Bappa L (2013) Primary vaginal non-Hodgkin lymphoma: gynecologic diagnosis of a hematologic malignancy. J Low Genit Tract Dis 17(3):326–329

    Article  PubMed  Google Scholar 

  • Ramalingam P, Zoroquiain P et al (2012) Florid reactive lymphoid hyperplasia (lymphoma-like lesion) of the uterine cervix. Ann Diagn Pathol 16(1):21–28

    Article  PubMed  Google Scholar 

  • Rappaport H (1966) Tumors of the hematopoietic system. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  • Roden AC, Hu X et al (2014) BRAF V600E expression in Langerhans cell histiocytosis: clinical and immunohistochemical study on 25 pulmonary and 54 extrapulmonary cases. Am J Surg Pathol 38(4):548–551

    Article  PubMed  Google Scholar 

  • Saglam A, Guler G et al (2005) Uterine leiomyoma with prominent lymphoid infiltrate. Int J Gynecol Cancer 15(1):167–170

    Article  PubMed  CAS  Google Scholar 

  • Sakurai N, Tateoka K et al (2008) Primary precursor B-cell lymphoblastic lymphoma of the ovary: case report and review of the literature. Int J Gynecol Pathol 27(3):412–417

    Article  PubMed  Google Scholar 

  • Santillan A, Montero AJ et al (2003) Vulvar langerhans cell histiocytosis: a case report and review of the literature. Gynecol Oncol 91(1):241–246

    Article  PubMed  Google Scholar 

  • Scully RE (1979) Tumors of the ovary and maldeveloped gonads. In: Atlas of tumor pathology. 2nd series, Fascicle 16. Armed Forces Institute of Pathology, Washington, DC, pp 117–127

    Google Scholar 

  • Sellami-Dhouib R, Nasfi A et al (2013) Ovarian ALK+ diffuse large B-cell lymphoma: a case report and a review of the literature. Int J Gynecol Pathol 32(5):471–475

    Article  PubMed  Google Scholar 

  • Shigematsu Y, Matsuura M et al (2016) Intravascular large B-cell lymphoma of the bilateral ovaries and uterus in an asymptomatic patient with a t(11,22)(q23;q11) constitutional translocation. Intern Med 55(21):3169–3174

    Article  PubMed  PubMed Central  Google Scholar 

  • Shulman LN, Hitt RA et al (2008) Case records of the Massachusetts General Hospital. Case 4–2008. A 33-year-old pregnant woman with swelling of the left breast and shortness of breath. N Engl J Med 358(5):513–523

    Article  PubMed  CAS  Google Scholar 

  • Spahr J, Behm FG et al (1982) Preleukemic granulocytic sarcoma of cervix and vagina. Initial manifestation by cytology. Acta Cytol 26:55–60

    PubMed  CAS  Google Scholar 

  • Sun J, Zhang J et al (2015) Primary diffuse large B-cell lymphoma of the ovary is of a germinal Centre B-cell-like phenotype. Virchows Arch 466(1):93–100

    Article  PubMed  CAS  Google Scholar 

  • Sur M, Ross C et al (2005) Intravascular large B-cell lymphoma of the uterus: a diagnostic challenge. Int J Gynecol Pathol 24(2):201–203

    Article  PubMed  Google Scholar 

  • Tahmasebi FC, Roy S et al (2015) Primary extranodal marginal zone lymphoma of the endometrium: report of four cases and review of literature. Int J Clin Exp Pathol 8(3):3036–3044

    PubMed  PubMed Central  CAS  Google Scholar 

  • Takimoto T, Maegawa S et al (2017) Extranodal marginal zone lymphoma of the uterine cervix with concomitant copy number gains of the MALT1 and BCL2 genes: a case report. Oncol Lett 13(5):3641–3645

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Terry J, Pluchinotta FR et al (2013) Congenital langerhans cell histiocytosis with placental involvement. Pediatr Dev Pathol 16(3):224–228

    Article  PubMed  Google Scholar 

  • Tjalma W, Van de Velde A et al (2002) Primary non-Hodgkin’s lymphoma in Bartholin’s gland. Gynecol Oncol 87(3):308–309

    Article  PubMed  Google Scholar 

  • Valeri RM, Ibrahim N et al (2002) Extramedullary hematopoiesis in the endometrium. Int J Gynecol Pathol 21(2):178–181

    Article  PubMed  Google Scholar 

  • Valli R, Froio E et al (2014) Diffuse large B-cell lymphoma occurring in an ovarian cystic teratoma: expanding the spectrum of large B-cell lymphoma associated with chronic inflammation. Hum Pathol 45(12):2507–2511

    Article  PubMed  Google Scholar 

  • van de Rijn M, Kamel O et al (1997) Primary low grade endometrial B-cell lymphoma. Am J Surg Pathol 21:187–194

    Article  PubMed  Google Scholar 

  • van der Velden VH, Willemse MJ et al (2001) Clearance of maternal leukaemic cells in a neonate. Br J Haematol 114(1):104–106

    Article  PubMed  Google Scholar 

  • Vang R, Medeiros L et al (2000a) Non-Hodgkin’s lymphoma involving the vulva. Int J Gynecol Pathol 19(3):236–242

    Article  PubMed  CAS  Google Scholar 

  • Vang R, Medeiros L et al (2000b) Non-Hodgkin’s lymphoma involving the vagina. A clinicopathologic analysis of 14 patients. Am J Surg Pathol 24(5):719–725

    Article  PubMed  CAS  Google Scholar 

  • Vang R, Medeiros LJ et al (2000c) Non-Hodgkin’s lymphomas involving the uterus: a clinicopathologic analysis of 26 cases. Mod Pathol 13(1):19–28

    Article  PubMed  CAS  Google Scholar 

  • Vang R, Medeiros L et al (2001a) Ovarian non-Hodgkin’s lymphoma: a clinicopathologic study of eight primary cases. Mod Pathol 14(11):1093–1099

    Article  PubMed  CAS  Google Scholar 

  • Vang R, Medeiros LJ et al (2001b) Non-Hodgkin’s lymphoma involving the gynecologic tract: a review of 88 cases. Adv Anat Pathol 8(4):200–217

    Article  PubMed  CAS  Google Scholar 

  • Venizelos ID, Mandala E et al (2006) Primary langerhans cell histiocytosis of the vulva. Int J Gynecol Pathol 25(1):48–51

    Article  PubMed  Google Scholar 

  • Wang GN, Zhao WG et al (2015) Primary natural killer/T cell lymphoma of the cervix: case report and clinicopathological analysis. Taiwan J Obstet Gynecol 54(1):71–74

    Article  PubMed  Google Scholar 

  • Wasson M, Hochman M et al (2015) Postmenopausal bleeding resulting from acute myeloid leukemia infiltration of the endometrium. Del Med J 87(7):212–215

    PubMed  Google Scholar 

  • Weiss L, Grogan T et al (2001) Langerhans cell histiocytosis. In: Jaffe E, Harris N, Stein H, Vardiman J (eds) Pathology and genetics: tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon, pp 280–282

    Google Scholar 

  • Wyld PH, Lilleyman JS (1983) Ovarian disease in childhood lymphoblastic leukemia. Acta Haematol 69:278–280

    Article  PubMed  CAS  Google Scholar 

  • Yadav R, Sharma MC et al (2013) Natural history of primary precursor B lymphoblastic lymphoma of the ovary: report of a rare case. J Obstet Gynaecol Res 39(2):611–616

    Article  PubMed  Google Scholar 

  • Yamada N, Uchida R et al (2005) CD5+ Epstein-Barr virus-positive intravascular large B-cell lymphoma in the uterus co-existing with huge myoma. Am J Hematol 78(3):221–224

    Article  PubMed  Google Scholar 

  • Yoshinaga K, Akahira J et al (2004) A case of primary mucosa-associated lymphoid tissue lymphoma of the vagina. Hum Pathol 35(9):1164–1166

    Article  PubMed  Google Scholar 

  • Young RH, Harris NL et al (1985) Lymphoma-like lesions of the lower female genital tract: a report of 16 cases. Int J Gynecol Pathol 4:289–299

    Article  PubMed  CAS  Google Scholar 

  • Zinzani P, Martelli M et al (2002) Induction chemotherapy strategies for primary mediastinal large B-cell lymphoma with sclerosis: a retrospective multinational study on 426 previously untreated patients. Haematologica 87:1258–1264

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA, USA

    Judith A. Ferry

Authors
  1. Judith A. Ferry
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Judith A. Ferry .

Editor information

Editors and Affiliations

  1. Johns Hopkins University Dept. Gynecology, Obstetrics & Pathology, Baltimore, Maryland, USA

    Robert J. Kurman

  2. Dept. Urology, New York Presbyterian Hospital Weill Cornell Medical Center, New York, New York, USA

    Lora Hedrick Ellenson

  3. Johns Hopkins University Dept. Gynecology, Obstetrics & Pathology, Baltimore, Maryland, USA

    Brigitte M. Ronnett

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Science+Business Media, LLC, part of Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Ferry, J.A. (2018). Hematologic Neoplasms and Selected Tumor-Like Lesions Involving the Female Reproductive Organs. In: Kurman, R., Hedrick Ellenson, L., Ronnett, B. (eds) Blaustein's Pathology of the Female Genital Tract. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3165-7_21-2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-3165-7_21-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-3165-7

  • Online ISBN: 978-1-4614-3165-7

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation