Skip to main content
SpringerLink
Log in
Book cover

Phosphate Metabolism pp 211–231Cite as

Interrelationships Between the Key Elements of the Vitamin D Endocrine System: 25-OH-D3-1-Hydroxylase, Serum Calcium and Phosphorus Levels, Intestinal 1,25(OH)2D3, and Intestinal Calcium Binding Protein

  • Chapter
  • First Online:

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 81))

Abstract

Calcium and phosphorus homeostasis is exquisitely regulated by the three hormones, calcitonin, parathyroid hormone, and cholecalciferol (vitamin D3). The most notable advance in our understanding of the mechanism of action of vitamin D has been the elucidation of the complex metabolic pathway which has evolved to produce the biologically active form, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Coupled with these developments concerning our understanding of the metabolic pathway of conversion of vitamin D into its active form, has been the realization that the mechanism of action of the fat soluble vitamin D is in reality similar to that of many of the classical steroid hormones, e.g. aldosterone, testosterone, estrogen, hydrocortisone, and ecdysterone. It should be noted that chemically vitamin D is in reality a steroid, in particular a seco steroid. Seco steroids are those in which one of the rings has undergone fission; in the instance of calciferol, this is ring B.

This work was supported by United States Public Health Service grants AM-09012 and AM-14,750.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Norman, A. W.: Actinomycin D and the response to vitamin D. Science 149:184, 1965.

    Article  CAS  Google Scholar 

  2. Zull, J.E., Misztal, C., and DeLuca, H.F.: On the relationship between vitamin D action and actinomycin-sensitive processes. Proc. Nat. Acad. Sei. (US) 55: 177, 1966.

    Article  CAS  Google Scholar 

  3. Wasserman, R. H.: The vitamin D-dependent calcium-binding protein, in, H. F. DeLuca and J. W. Suttie (eds.) The Fat-Soluble Vitamins, Univ. of Wisconsin Press, p. 21, 1969.

    Google Scholar 

  4. Norman, A. W., and Henry, H.: 1,25-Dihydroxylcholecalciferol-a hormonally active form of vitamin D3, in, R. O. Greep (ed.) Recent Progress in Hormone Research 30:431, 1974.

    Google Scholar 

  5. Henry, H., and Norman, A. W.: Presence of renal 25-hydroxyvitamin D-1-hydroxylase in species of all vertebrate classes. Comp. Biochem. Physiol. 50:431, 1975.

    CAS  Google Scholar 

  6. Omdahl, J. L., Gray, R. W., Boyle, I. T., Knutsen, J., and DeLuca, H. F.: Regulation of metabolism of 25-hydroxycholecal-ciferol by kidney tissue in vitro by dietary calcium. Nature New Biol. 237:63, 1972.

    Article  CAS  Google Scholar 

  7. Boyle, I. T., Gray, R. W., and DeLuca, H. F.: Regulation by calcium of in vivo synthesis of 1,25-dihydroxycholecalciferol and 21,25-dihydroxycholecalciferol. Proc. Nat. Acad. Sci. US 68:2131, 1971.

    Article  CAS  Google Scholar 

  8. Edelstein, S., Harell, A., Bar, A., and Hurwitz, S.: The functional metabolism of vitamin D in chicks fed low-calcium and low-phosphorus diets. Biochim. Biophys. Acta 385:438, 1975.

    Article  CAS  Google Scholar 

  9. Tanaka, Y., and DeLuca, H. F.: The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus. Arch. Biochem. Biophys. 154:566, 1973.

    Article  CAS  Google Scholar 

  10. Hughes, M. R., Brumbaugh, P. F., Haussler, M. R., Wergedal, J. E., and Baylink, D. J.: Regulation of serum 1α,25-dihydroxy-vitamin D3 by calcium and phosphate in the rat. Science 190:578, 1975.

    Article  CAS  Google Scholar 

  11. Henry, H. L., Midgett, R. J., and Norman, A. W.: Regulation of 25-hydroxyvitamin D3-1-hydroxylase, in vivo. J. Biol. Chem. 249:7584, 1974.

    CAS  PubMed  Google Scholar 

  12. Fraser, D. R., and Kodicek, E.: Regulation of 25-hydroxychole-calciferol-1-hydroxylase activity in kidney by parathyroid hormone. Nature New Biol. 241:163, 1973.

    Article  CAS  Google Scholar 

  13. Tanaka, Y., Lorenc, R. S., and DeLuca, H. F.: The role of 1,25 dihydroxyvitamin D3 and parathyroid hormone in the regulation of chick renal 25-hydroxyvitamin D3-24-hydroxylase. Arch. Biochem. Biophys. 171:521, 1975.

    Article  CAS  Google Scholar 

  14. Garabedian, M., Holick, M. F., DeLuca, H. F., and Boyle, I. T.: Control of 25-hydroxycholecalciferol metabolism by parathyroid glands. PNAS 69:1673, 1972.

    Article  CAS  Google Scholar 

  15. Favus, M. J., Walling, M. W., and Kimberg, D. V.: Effects of dietary calcium restriction and chronic thyroparathyroidectomy on the metabolism of [3H]25-hydroxyvitamin D3 and the active transport of calcium by rat intestine. J. Clin. Invest. 53:1139, 1974.

    Article  CAS  Google Scholar 

  16. Seymour, J. L., and DeLuca, H. F.: Action of 25-hydroxydihy-drotachysterol3 on calcium metabolism in normal and thyropara-thyroidectomized rats. Endocrinology 94:1009, 1974.

    Article  CAS  Google Scholar 

  17. Haussier, M. R.: Vitamin D3: metabolism, mode of action, and assay of circulating hormonal form, in, A. W. Norman, K. Schaefer, H.-G. Grigoleit, D. von Herrath, and E. Ritz (eds.), Vitamin D and Problems Relating to Uremic Bone Disease. Walter de Gruyter, p. 25, 1975.

    Google Scholar 

  18. Galante, L., Colston, K., MacAuley, S., and Maclntyre, I.: Effect of parathyroid extract on vitamin D metabolism. The Lancet 7, 985, 1972.

    Article  Google Scholar 

  19. Galante, L., Colston, K. W., MacAuley, S. J., and Maclntyre, I.: Effect of calcitonin on vitamin D metabolism. Nature 238:271, 1972.

    Article  CAS  Google Scholar 

  20. Henry, H. L., and Norman, A. W.: Studies on calciferol metabolism. IX. Renal 25-hydroxy-vitamin D3-1-hydroxylase. Involvement of cytochrome P450 and other properties. J. Biol. Chem. 249:7529, 1974.

    CAS  PubMed  Google Scholar 

  21. Horiuchi, N., Suda, T., and Sasaki, S.: Direct involvement of vitamin D in the regulation of 25-hydroxycholecalciferol metabolism. FEBS Letters 43(3):353, 1974.

    Article  CAS  Google Scholar 

  22. Tanaka, Y., and DeLuca, H. F.: Stimulation of 24, 25-di-hydroxy-vitamin D3. Science 183:1198, 1974.

    Article  CAS  Google Scholar 

  23. Henry, H. L., and Norman, A. W.: Studies on the mechanism of action of calciferol. VII. Localization of 1,25-dihydroxy-vitamin D3 in chick parathyroid glands. Biochem. Biophys. Res. Commun. 62:781, 1975.

    Article  CAS  Google Scholar 

  24. Henry, H. L., and Norman, A. W.: Studies on calciferol metabolism. XIII. Regulation of 25-hydroxy-vitamin D3-1-hydroxylase in isolated renal mitochondria. Arch. Biochem. Biophys. 172:582, 1976.

    Article  CAS  Google Scholar 

  25. Chazarian, J.G., and DeLuca, H. F.: 25-Hydroxycholecalcif-erol-1-hydroxylase: A specific requirement for NADPH and a hemoprotein component in chick kidney mitochondria. Arch. Biochem. Biophys. 160:63, 1974.

    Article  Google Scholar 

  26. Suda, T., Horiuchi, N., Sasaki, S., Ogata, E., Izawa, I., Nagata, W., and Kimura, S.: Direct control by calcium of 25-hydroxycholecalciferol-1-hydroxylase activity in chick kidney mitochondria. Biochem. Biophys. Res. Commun. 54:512, 1973.

    Article  CAS  Google Scholar 

  27. Horiuchi, N., Suda, T., Sasaki, S., Ogata, E., Izawa, I., Sano, Y., and Shimazawa, E.: The regulatory role of calcium in 25-hydroxycholecalciferol metabolism in chick kidney in vitro. Arch. Biochem. Biophys. 171, 540, 1975.

    Article  CAS  Google Scholar 

  28. Colston, K. W., Evans, I. M. A., Galante, L., Maclntyre, I., and Moss, D. W.: Regulation of vitamin D metabolism: factors influencing the rate of formation of 1,25-dihydroxycholecal-ciferol by kidney homogenates. Biochem. J. 134:817, 1973.

    Article  CAS  Google Scholar 

  29. Bikle, D. D., Murphy, E. W., and Rasmussen, H.: The ionic control of 1,25-dihydroxyvitamin D3 synthesis in isolated chick renal mitochondria. J. Clin. Invest. 55:299, 1975.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of California, Riverside, California, 92502, USA

    Anthony W. Norman, Ernest J. Friedlander & Helen Henry

Authors
  1. Anthony W. Norman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ernest J. Friedlander
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Helen Henry
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. Department of Internal Medicine, University of Heidelberg, Heidelberg, Germany

    Eberhard Ritz

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Springer Science+Business Media New York

About this chapter

Cite this chapter

Norman, A.W., Friedlander, E.J., Henry, H. (1977). Interrelationships Between the Key Elements of the Vitamin D Endocrine System: 25-OH-D3-1-Hydroxylase, Serum Calcium and Phosphorus Levels, Intestinal 1,25(OH)2D3, and Intestinal Calcium Binding Protein. In: Massry, S.G., Ritz, E. (eds) Phosphate Metabolism. Advances in Experimental Medicine and Biology, vol 81. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-4217-5_23

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-4217-5_23

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-4219-9

  • Online ISBN: 978-1-4613-4217-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation