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New Directions in Understanding Dementia and Alzheimer’s Disease pp 21–29Cite as

In Search of the Etiology of Alzheimer’s Disease

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 282))

Abstract

Alzheimer’s disease is defined by a characteristic neuropathology consisting of neurofibrillary tangles made up of intraneuronal paired helical filaments and straight filaments, and senile plaques made up of a core of extracellular amyloid fibrils surrounded by dystrophic neurites and glial cells, the accumulation of the same amyloid fibrils in cerebral and meningeal microvessels and loss of neurones. This neuropathology predominantly affects the frontal, parietal and temporal cortex, and hippocampus.

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References

  1. Blass, J. P. and Zemcov, A. (1984). Alzheimer’s disease: A metabolic systems degeneration? Neurochem.Path., 2: 103–114.

    Article  CAS  Google Scholar 

  2. Friedland, R. P. (moderator), Koss, E., Haxby, J. V., Grady, C. L., Luxenberg, J., Shapiro, M. B., and Kay, J. (discussants) (1988). Alzheimer’s disease: Clinical and biological heterogeneity. Ann. Intern. Med., 109: 298–311.

    PubMed  CAS  Google Scholar 

  3. Spencer, P. S., Nunn, P. B., Hugon, J., et al. (1987). Guam amyotrophic lateral sclerosis- Parkinsonism-dementia linked to a plant excitant neurotoxin. Science, 237: 517–522.

    Article  PubMed  CAS  Google Scholar 

  4. Lieberman, A. N. (1987). Update on Parkinson’s disease. New York State J. Med., 87: 147–152.

    CAS  Google Scholar 

  5. Perl, D. P. and Pendlebury, W. W. (1986). Aluminum neurotoxicity-potential role in the pathogenesis of neurofibrillary tangle formation. Can. J. Neurol. Sci., 13: 441: 445.

    Google Scholar 

  6. Prusiner, S. B. (1987). Prions and neurodegenerative diseases. New Engl. J. Med., 317: 1571–1581.

    Article  PubMed  CAS  Google Scholar 

  7. Corsellis, J. A. N. (1986). The transmissibility of dementia. Brit. Med. Bull., 42: 111–114.

    PubMed  CAS  Google Scholar 

  8. Manuelidis, E. E., DeFigueiredo, J. M., Kim, J. H., et al. (1988). Transmission studies from blood of Alzheimer disease patients and healthy relatives. Proc. Natl. Acad. Sci. USA, 85: 4898–4901.

    Article  PubMed  CAS  Google Scholar 

  9. St. George-Hyslop, P. H., Tanzi, R. E., Polinsky, R. J., et al. (1987). The genetic defect causing familial Alzheimer’s disease maps on chromosome 21. Science, 235: 885–889.

    Article  PubMed  CAS  Google Scholar 

  10. Van Broeckhoven, C., Genthe, A. M., Vandenberghe, A., et al. (1987). Failure of familial Alzheimer’s disease to segregate with the A4 amyloid gene in several European families. Nature (London), 329: 153–155.

    Article  PubMed  Google Scholar 

  11. Tanzi, R. E., St. George-Hyslop, P. H., Haines, J. L., et al. (1987). The genetic defect in familial Alzheimer’s disease is not tightly linked to the amyloid B protein gene. Nature (London), 329: 156–157.

    Article  PubMed  CAS  Google Scholar 

  12. Peterson, C. and Goldman, J. E. (1986). Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors. Proc. Natl. Acad. Sci. USA, 83: 2758–2762.

    Article  PubMed  CAS  Google Scholar 

  13. Baker, A. C., Ko, L. W., Shea, R. K. F., et al. (1988). Studies of “neuronal” and “Alzheimer” antigens in skin cells. Alzheimer’s Disease and Associated Disorders, 2: 178.

    Article  Google Scholar 

  14. Robbins, J. H. (1983). Hypersensitivity to DNA-damaging agents in primary degeneration of excitable tissue. In Bridges, B. A. and Friedberg, E. C. (eds), Cellular Responses to DNA Damage. Alan R. Liss, New York.

    Google Scholar 

  15. Robbins, J. H., Otsuka, F., Tarone, R. E., et al. (1983). Radiosensitivity in Alzheimer’s disease and Parkinson’s disease. Lancet, 1: 468–469.

    Article  PubMed  CAS  Google Scholar 

  16. Li, J. C. and Kaminskas, E. (1985). Deficient repair of DNA lesions in Alzheimer’s disease fibroblasts. Biochem. Biophys. Res. Comm., 129: 733–738.

    Article  PubMed  CAS  Google Scholar 

  17. Robinson, S. H. and Bradley, E. G. (1985). Impaired DNA repair replication in Alzheimer’s disease cells. In Hutton, J. T. and Kenney, A. D. (eds), Senile Dementia of the Alzheimer’s Type. Alan R. Liss, New York.

    Google Scholar 

  18. Edwards, J. A., Wang L. G., Setlow, R. B., and Kaminskas, E. (1989). Lymphocyte 0°-methylguanine DNA methyltransferase in the elderly with and without Alzheimer’s disease. Mut. Res., 219:267–272.

    CAS  Google Scholar 

  19. Goldgaber, D., Lerman, M. I., McBride, O. W., et al. (1987). Characterization and chromosomal location of a cDNA encoding brain amyloid of Alzheimer’s disease. Science, 235: 877–880.

    Article  PubMed  CAS  Google Scholar 

  20. Tanzi, R. E., Gusella, J. F., Watkins, P. C., et al. (1987). Amyloid B protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science, 235: 880–884.

    Article  PubMed  CAS  Google Scholar 

  21. Glenner, G. G. and Wong, C. E. (1984). Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Comm., 120: 885–890.

    Article  PubMed  CAS  Google Scholar 

  22. Masters, C. L., Simms, G., Weinman, N. A., et al. (1985). Amyloid plaque core protein in Alzheimer’s disease and Down’s syndrome. Proc. Natl. Acad. Sci. USA, 82: 4245–4249.

    Article  PubMed  CAS  Google Scholar 

  23. Kang, J., Lemaine, H. G., Unterbeck, A., et al. (1987). The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell surface receptor. Nature (London), 325: 733–736.

    Article  PubMed  CAS  Google Scholar 

  24. Marx, J. L. (1989). Brain protein yields clues to Alzheimer’s disease. Science, 243: 1664–1666.

    Article  PubMed  CAS  Google Scholar 

  25. Whitson, J. S., Selkoe, D. J., Cotman, C. W. (1989). Amyloid B protein enhances the survival of hippocampal neurones in vitro. Science, 243: 1488–1490.

    Article  PubMed  CAS  Google Scholar 

  26. Pardridge, W. M., Microvessels from Alzheimer’s disease brain: Biochemistry of amyloid peptides, pp. 48–51. In Vinters, H. V., moderator (1988). Brain amyloid and Alzheimer’s disease. Ann. Intern. Med., 109:41–54.

    Google Scholar 

  27. Rumble, B, Retallack, R., Hilbich, C., et al. (1989). Amyloid A4 protein and its precursor in Down’s syndrome and Alzheimer’s disease. New Engl. J. Med., 320: 1446–1452.

    Article  PubMed  CAS  Google Scholar 

  28. Selkoe, D. J. (1989). Aging, amyloid, and Alzheimer’s disease. New Engl. J. Med., 320: 1484–1487.

    Article  PubMed  CAS  Google Scholar 

  29. Abraham, C. R., Selkoe, D. J., and Potter, H. (1988). Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer’s disease. Cell, 52: 487–501.

    Article  PubMed  CAS  Google Scholar 

  30. Joachim, C. L., Morris, J. and Selkoe, D. J. (1989). Diffuse senile plaques occur commonly in the cerebellum in Alzheimer’s disease. Am. J. Pathol., 135: 309–319.

    PubMed  CAS  Google Scholar 

  31. St. George-Hyslop, P. H., Tanzi, R. E., Polinsky, R. J., et al. (1987). Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer’s disease. Science, 238: 664–666.

    Article  PubMed  CAS  Google Scholar 

  32. Tanzi, R. E., Bird, E. D., Latt, S. A., et al. (1987). The amyloid B gene is not duplicated in brains from patients with Alzheimer’s disease. Science, 238: 666–669.

    Article  PubMed  CAS  Google Scholar 

  33. Yamaguchi, H., Hirai, S., Morimatsu, M., et al. (1988). A variety of cerebral amyloid deposits in the brain of the Alzheimer’s-type dementia demonstrated by beta protein immunostaining. Acta Neurolpathol., 76: 541–590.

    Article  CAS  Google Scholar 

  34. Giacone, G., Tagliavini, F., Linoli, G., et al. (1989). Down patients: Extracellular preamyloid deposits precede neuritic degeneration and senile plaques. Neuro. Sci. Lett., 97: 323–328.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Departments of Medicine and Family Medicine, State University of New York at Buffalo, Buffalo, New York, USA

    John A. Edwards M.D., F.A.C.P., F.R.C.P. (Professor)

Authors
  1. John A. Edwards M.D., F.A.C.P., F.R.C.P.
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Editor information

Editors and Affiliations

  1. Northeastern New York Alzheimer’s Disease Assistance Center, SUNY, Plattsburgh, New York, USA

    Taher Zandi Ph.D. (Associate Professor of Psychology, Director) (Associate Professor of Psychology, Director)

  2. Central New York Alzheimer’s Disease Assistance Center, SUNY Health Science Center, Syracuse, New York, USA

    Richard J. Ham M.D.

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© 1990 Plenum Press, New York

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Edwards, J.A. (1990). In Search of the Etiology of Alzheimer’s Disease. In: Zandi, T., Ham, R.J. (eds) New Directions in Understanding Dementia and Alzheimer’s Disease. Advances in Experimental Medicine and Biology, vol 282. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0665-8_2

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  • DOI: https://doi.org/10.1007/978-1-4613-0665-8_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7917-4

  • Online ISBN: 978-1-4613-0665-8

  • eBook Packages: Springer Book Archive

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