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Introduction to Specific Drug Action and Membrane Surface Phenomena

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Principles in General Pharmacology

Part of the book series: Springer Series in Pharmacologic Science ((SSPHARMACOL))

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Abstract

Drugs are believed to produce their effects on biological systems either by alteration of some physical property of the cell or by a specific chemical reaction between the drug and its receptor. Many drugs produce their effects by interacting with specific cellular receptors. A description of the mathematical analysis of the interaction of drugs with receptors can be found in Chapter 8. The present chapter presents only an outline of the general development of the drug-receptor concept and highlights those aspects of the development which are considered by many the “principles” underlying present conceptions of the drug-receptor interaction. A more recent development, the recognition of cell processes (e.g., membrane capping, coated pits, and coated vesicles) capable of modifying the number of cell-surface receptors, is described in more detail.

. . . we may, I think, without much rashness, assume that there is some substance or substances in the nerve endings or gland cells with which [drugs] are capable of forming compounds. —J.N. Langley, 1878.

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Authors and Affiliations

  1. Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, 19140, USA

    Ronald J. Tallarida Ph.D. (Professor of Pharmacology) & Robert B. Raffa Ph.D. (Senior Scientist, Adjunct Assistant Professor)

  2. Janssen Research Foundation, Spring House, Pennsylvania, 19477, USA

    Robert B. Raffa Ph.D. (Senior Scientist, Adjunct Assistant Professor)

  3. Jefferson Medical College, Philadelphia, Pennsylvania, 19107, USA

    Robert B. Raffa Ph.D. (Senior Scientist, Adjunct Assistant Professor)

  4. Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    Paul McGonigle Ph.D. (Assistant Professor)

Authors
  1. Ronald J. Tallarida Ph.D.
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  2. Robert B. Raffa Ph.D.
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  3. Paul McGonigle Ph.D.
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© 1988 Springer-Verlag New York Inc.

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Tallarida, R.J., Raffa, R.B., McGonigle, P. (1988). Introduction to Specific Drug Action and Membrane Surface Phenomena. In: Principles in General Pharmacology. Springer Series in Pharmacologic Science. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3778-5_5

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  • DOI: https://doi.org/10.1007/978-1-4612-3778-5_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8346-1

  • Online ISBN: 978-1-4612-3778-5

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