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Immunological Difficulties and Requirements for Immune Manipulations in the Field of Reproduction

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Contraception Research for Today and the Nineties

Part of the book series: Progress in Vaccinology ((VACCINOLOGY,volume 1))

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Abstract

Immune manipulations in the field of reproduction have two potential applications aiming at two opposite goals: (a) immunotherapy for sterility and repeated abortions and (b) anticonceptional vaccination for control of fertility.

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References

  1. Badet MT, Chateaureynaud-Duprat P, Mouches C, et al: Séparation et étude de deux facteurs sériques responsables de l’inhibition de la réaction cytotoxique maternelle à l’égard des cellules embryonnaires, chez la salamandre gestante. Ann Immunol (Paris) 1980: 131 D: 57–69.

    Google Scholar 

  2. Beer AE: The paradox of foeto-placental units as allografts, in Talwar GP (ed): Recent Advances in Reproduction and Regulation of Fertility. Amsterdam, Elsevier/North Holland, 1979, pp 501–513.

    Google Scholar 

  3. Bell SC, Billington WD: Major anti-paternal alloantibody induced by murine pregnancy is non-complement-fixing IgGl. Nature 1980;288:387–388.

    Article  PubMed  CAS  Google Scholar 

  4. Billington WD, Davies M, Bell SC: Maternal antibody to foetal histocompatibility and trophoblast-specific antigens, Ann Immunol (Paris) 1984;135:331–335.

    Google Scholar 

  5. Bobe P, Doric M, Kinsky RG, et al: Modulation of mouse anti-SRBC antibody response by placental extracts. Cell Immunol 1984;89:355–364.

    Article  PubMed  CAS  Google Scholar 

  6. Bobe P, Kanellopoulos-Lange vin C, Bleux C, et al: Modulation of mouse anti-SRBC antibody responses by placental extracts. II. Antigen specificity and regulatory role of B and T cell populations affected by two distinct placental fractions. J Immunol 1986;136:574–581.

    PubMed  CAS  Google Scholar 

  7. Brierley J, Clark DA: Characterization of a hormone-dependent suppressor cell in the uterus of pregnant and pseudopregnam mice. J Reprod Immunol [Suppl] 1986;6:118.

    Google Scholar 

  8. Chaouat G, Voisin GA: Regulatory T cell subpopulations in pregnancy. I, Evidence for suppressive activity of the early phase of MLR. J Immunol 1979;122:1383–1388.

    PubMed  CAS  Google Scholar 

  9. Chaouat G, Voisin GA: Regulatory T cells in pregnancy. IV. Genetic characteristics and mode of action of early MLR suppressive T cell subpopulations, J Immunol 1981;127:1335–1339.

    PubMed  CAS  Google Scholar 

  10. Chaouat G, Voisin GA: Regulatory T cells in pregnancy. V. Allopregnancy induced T-cell-suppressor factor is H-2 restricted and bears la determinants. Cell Immunol 1981;62:186–195.

    Article  PubMed  CAS  Google Scholar 

  11. Chaouat G, Voisin GA, Escalier D, et al: Facilitation reaction (enhancing antibodies and suppressor cells) and rejection reaction (sensitized cells) from the mother to the paternal antigens of the conceptus. Clin Exp Immunol 1979;35:13–24.

    PubMed  CAS  Google Scholar 

  12. Chaouat G, Kinsky RG, Due HT, et al: The possibility of anti-idiotypic activity in multiparous mice. Ann Immunol (Paris) 1979;130:601–605.

    Google Scholar 

  13. Chaouat G, Chaffaux S, Duchet-Suchaux M, et al: Immunoactive products of mouse placenta: 1.1 mnt u no-suppressive effects of crude and water soluble extracts. J Reprod Immunol 1980;2:127–139.

    Article  Google Scholar 

  14. Chaouat G, Monnot P, Hoffmann M, et al: Regulatory T cells in pregnancy. VI. Evidence for T-cell-mediated suppression of CTL generation toward paternal alloantigens. Cell Immunol 1982;68:322–331.

    Article  PubMed  CAS  Google Scholar 

  15. Chaouat G, Kolb JP, Riviere M: Role of the placental interface and of trophoblast/maternal tissue interactions in the survival of the murine foetal allograft. Ann Immunol (Paris) 1984:135:302–306.

    Google Scholar 

  16. Chateaureynaud P, Badet MT, Voisin GA: Antagonistic maternal immune reactions (rejection and facilitation) to the embryo in the urodele amphibian Salamandra salamandra Lin. J Reprod Immunol 1979;1:47–60.

    Article  PubMed  CAS  Google Scholar 

  17. Cooper EL, Rubilotta LM: Allograft rejection in Eisenia Foetida. Transplantation 1969;8:220–223.

    Article  PubMed  CAS  Google Scholar 

  18. DAlmeida M, Voisin GA: Resistance of female guinea pig fertility to efficient isoimmunization with spermatozoa autoantigens. J Reprod Immunol 1979; 1:237–247.

    Article  CAS  Google Scholar 

  19. Duc HT, Monnot P, Voisin GA: Inhibitory effects of placental extracts on the effector CTL, in vitro action. 5th Int. Congress of Immunology, workshop presentation 706.28, Kyoto, Japan, 1983, p 208.

    Google Scholar 

  20. Duc HT, Masse A, Bobe P, et al: Deviation of humoral and cellular alloimmune reactions by placental extracts. J Reprod Immunol 1985;7:27–39.

    Article  PubMed  CAS  Google Scholar 

  21. Duc HT, Monnot P, Righenzi S, et al: The in vitro immunomodulatory effect of placental substances on mixed lymphocyte reaction (MLR) and cell mediated lysis (CML). Fed Proc 1986;45:631.

    Google Scholar 

  22. Duc HT, Righenzi S, Monnot P, et al: Immunomodulatory effects of placental substances on mixed lymphocyte reaction (MLR) and cell mediated lysis (CML). J Reprod Immunol [Suppl] 1986;6:116.

    Google Scholar 

  23. Duprat P: Etude de la prise et du maintien d’un greffon de paroi du corps chez le lombricien Eisenia Foetida Typica. Ann Inst Pasteur (Paris) 1967; 113:867–881.

    CAS  Google Scholar 

  24. Faulk WP. Mclntyre JA: Immunologie studies of human trophoblast: markers, subsets and functions. Immunol Rev 1983;75:139–175.

    Article  PubMed  CAS  Google Scholar 

  25. Gill TJ: Speculations on the transplantation biology of the maternal-fetal interface. Ann Immunol (Paris) 1984;135:307–309.

    Google Scholar 

  26. Goldberg E: Effects of immunization with LDH-X on fertility, in Diczfalusy E (ed): Immunological Approaches to Fertility Control. Stockholm, Karolinska Institutet Publication, 1974, pp 202–222.

    Google Scholar 

  27. Gupta GS, Kinsky R, Duc HT, et al: Effects of placental extracts on the immune response to histocompatibility antigens: class deviation of alloantibody response and allograft enhancement. Am J Reprod Immunol 1984;6:117–123.

    PubMed  CAS  Google Scholar 

  28. Hjort T: Immunological capacity of the male genital tract. A workshop report, in Boettcher B (ed): Immunological Influence on Human Infertility. New York, Academic Press, 1977, pp 115–117.

    Google Scholar 

  29. Hutcheson RB, Anderson TD, Holborow EJ; Cervical plasma cell population in infertile patients. Br Med J 1974;3:783–784.

    Article  PubMed  CAS  Google Scholar 

  30. Jarcho J: Artificial production of sterility with special reference to experimental temporary sterility biologically induced in the female. Am J Obstet Gynecol 1928; 16:813–827.

    Google Scholar 

  31. Jones WR: Immunological factors in male and female infertility, in Hearn JP (ed): Immunological Aspects of Reproduction and Fertility Control. Falcon-House, England, MTP Press, 1980, pp 105–140.

    Google Scholar 

  32. Kolk AHJ, Samuel T: Isolation, chemical and immunological characterization of two strongly basic nuclear proteins from human spermatozoa. Biochem Biophys Acta 1975;393:307–319.

    PubMed  CAS  Google Scholar 

  33. Kremer J, Jager S, Kuiken J: The clinical significance of antibodies to spermatozoa, in Boettcher B (ed): Immunological Influence on Human Fertility. Sydney, Academic Press, 1977, pp 47–66.

    Google Scholar 

  34. McAnulty PA, Morton DB: J Clin Lab Immunol 1978; 1:255.

    PubMed  CAS  Google Scholar 

  35. Maillard JL, Voisin GA: Elicîtation of Arthus reactions in guinea pigs by homologous yl and y2 immunoglobulins. Proc Soc Exp Biol Med 1970;133:1188–1194.

    PubMed  CAS  Google Scholar 

  36. Marcus ZH, Dondero F, Lunenfeld B, et al: Effect of the inhibitory material from male genital tract on natural killing activities. Immunol Lett 1985;10:1–5.

    Article  PubMed  Google Scholar 

  37. McCartney JL:Am J Physiol 1923;63:207.

    CAS  Google Scholar 

  38. Marquant-Le Guienne B, De Almeida M: Role of guinea-pig sperm autoantigens in capacitation and the acrosome reaction. J Reprod Fertil 1986;77:337–345.

    Article  Google Scholar 

  39. Metalnikoff S: Etudes sur la spermotoxinc. Ann Inst Pasteur (Paris) 1900;14:577–589.

    CAS  Google Scholar 

  40. Munoz de Vera G, Marquant-Le Guienne B, De Almeida M, et al; Role of guinea-pig sperm autoantigens in sperm binding to the zona pel lue Ida and oocyte penetration. J Reprod Fertil 1986;77:347–353.

    Article  PubMed  CAS  Google Scholar 

  41. Oki A, Sercarz E: T cell tolerance studied at the level of antigenic determinants, I. Latent reactivity to lysozyme peptides that lack suppressogenic epitopes can be revealed in lysozyme-tolerant mice. J Exp Med 1985; 161:897–911.

    Article  PubMed  CAS  Google Scholar 

  42. Prakash C, Coutinho A, Moller G: Inhibition of in vitro immune responses by a fraction from seminal plasma. Scand J Immunol 1976;5:77–85.

    Article  PubMed  CAS  Google Scholar 

  43. Prehn RT: The immune reaction as a stimulator of tumor growth, Science 1972; 176:170–172.

    Article  PubMed  CAS  Google Scholar 

  44. Rocklin RE, Zukerman JE, Alpert E, et al: Effect of multiparity on human maternal hypersensitivity to foetal antigen. Nature 1973;241:130–131.

    Article  PubMed  CAS  Google Scholar 

  45. Slapsys RM, Beeson JH, Clark DA: Localization of the trophoblast dependent decidua-associated suppressor cell. J Reprod Immunol [Suppl] 1986;6:121.

    Google Scholar 

  46. Tiffoche C, Kanellopoulos J, Voisin GA: Solubilization and partial characterization of guinea pig spcrmatozoal plasma membrane T autoantigen. Fed Proc 1985; 44:959.

    Google Scholar 

  47. Toullet F, Chadetiier F, Maillard JL, et al: Cellular transfer of autoimmune aspermogenic orchiepididymitis (AIAO) by the i.v. route in the guinea pig. Clin Exp Immunol 1985;59:593–603.

    PubMed  CAS  Google Scholar 

  48. Vaerman JP, Ferin J: Local immunological response in the vagina, cervix and endometrium, in Diczfalusy E (ed); Immunological approach of fertility control. Stockholm, Karol in ska Institutet Publication, 1974, pp 281–301.

    Google Scholar 

  49. Voisin GA: Le phénomène de facilitation immunologique, concept élargi du “enhancement phenomenon,” in Miescher PA, Grabar P (ed); IVth International Symposium Immunopathology. Bale, Stuttgart, Schwabe & Co, 1966, pp 165–193.

    Google Scholar 

  50. Voisin GA: Immunological facilitation, a broadening of the concept of the enhancement phenomenon. Prog Allergy 1971; 15:328–485.

    Article  PubMed  CAS  Google Scholar 

  51. Voisin GA: Immunity and tolerance: a unified concept. Cell Immunol 1971;2:670–689.

    Article  PubMed  CAS  Google Scholar 

  52. Voisin GA: Sperm specific autoantigens, in Shulman S, Dondero F, Nicotra M (eds): Immunological Factors in Human Reproduction. New York, Academic Press, 1982, pp 147–161.

    Google Scholar 

  53. Voisin GA: Enhancing antibodies and suppressor cells in pregnancy: role of the placentation, in lojima S, Billington WD (eds): Reproductive Immunology. Amsterdam, Elsevier, 1983, pp 121–131.

    Google Scholar 

  54. Voisin GA: Spermatozoa autoantigens in animals. A possible way for immunological contraception, in: Immunological Factors in Human Contraception. Roma, ACTA MEDICA, 1983, pp 23–38.

    Google Scholar 

  55. Voisin GA: Antigen-bearing targets have selected the immune mechanisms and their regulation during evolution: the example of gestation. Asian Pac J Allergy Immun 1984a;2:293–300.

    CAS  Google Scholar 

  56. Voisin GA; Active immunization against sperm and sperm autoantigens, in Crighton DB (ed): Immunological Aspects of Reproduction in Mammals. London, Butterworths Scientific Ltd, 1984, pp 291–303.

    Google Scholar 

  57. Voisin GA: Levels and nature of immunoregulatory mechanisms in pregnancy. Contrib Gynecol Obstet 1985;14:36–43.

    PubMed  CAS  Google Scholar 

  58. Voisin GA, Chaouat G: Demonstration, nature and properties of maternal antibodies fixed on placenta and directed against paternal antigens. J Reprod Fertil [SuppI] 1974;21:89–103.

    Google Scholar 

  59. Voisin GA, Toullet F: Autoimmune aspermatogenic orchitis (A.I.A.O.). A model for three possible mechanisms of autoimmune lesions. Folia Allergol (Roma) 1971; 1S: 310–316.

    Google Scholar 

  60. Voisin GA, Kinsky RG, Duc HT: Immune status of mice tolerant of living cells. IL Continuous presence and nature of facilitation-enhancing antibodies in tolerant animals. J Exp Med 1972;135:1185–1203.

    Article  PubMed  CAS  Google Scholar 

  61. Voisin JE, Monnot P, Voisin GA: Maternal alloimmune reactions towards the murine conceptus and graft-versus-host reaction (GVHR). I. Priming for antipaternal GVHR by gestation. J Reprod Immunol 1986;9:73–83.

    Article  PubMed  CAS  Google Scholar 

  62. Voisin JE, Kinsky RG, Voisin GA: Maternal alloimmune reactions towards the murine conceptus and graft-versus-host reaction (GVHR). II. Inhibition of priming by placental extracts, J Reprod Immunol 1986;9:85–94.

    Article  PubMed  CAS  Google Scholar 

  63. Wegmann TG, Singh B, Carlson GA: Allogeneic placenta is a paternal strain antigen immunoabsorbent. J Immunol 1979;122:270–274.

    PubMed  CAS  Google Scholar 

  64. Wegmann TG: Foetal protection against abortion: is it immunosuppression or immunostimulation? Arm Immunol (Paris) 1984;135:301–351.

    Google Scholar 

  65. Wrezlewicz W, Rashkoff E, Lucas T, et al: Effects of human chorionic gonadotropin and anti-thymocyte globulin on the electrophoretic mobility of human lymphocytes. Transplant Proc 1977;9:1441–1445.

    PubMed  CAS  Google Scholar 

  66. Youtananukorn V, Matangkasombut P, Osathanondh V: Onset of human maternal cellmediated immune reaction to placental antigens during the first pregnancy. Clin Exp Immunol 1974;16:593–598.

    CAS  Google Scholar 

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Voisin, G.A. (1988). Immunological Difficulties and Requirements for Immune Manipulations in the Field of Reproduction. In: Talwar, G.P. (eds) Contraception Research for Today and the Nineties. Progress in Vaccinology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3746-4_34

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  • DOI: https://doi.org/10.1007/978-1-4612-3746-4_34

  • Publisher Name: Springer, New York, NY

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