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Platelet Inhibitors

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Adverse Cutaneous Drug Reactions to Cardiovascular Drugs

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Abstract

The cutaneous adverse effects of aspirin (acetylsalicylic acid), dipyridamole, ticagrelor, cangrelor; thienopyridine derivatives such as ticlopidine, clopidogrel, and prasugrel; and platelet glycoprotein IIb/IIIa receptor antagonists such as abciximab, tirofiban, and eptifibatide are reviewed in this chapter. Aspirin is more commonly associated with cutaneous reactions due to its use as a nonsteroidal antiinflammatory drug.

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References

  1. Gollapudi RR, Teirstein PS, Stevenson DD, Simon RA. Aspirin sensitivity: implications for patients with coronary artery disease. JAMA. 2004;292:3017–23.

    Article  CAS  PubMed  Google Scholar 

  2. Grattan CE. Aspirin sensitivity and urticaria. Clin Exp Dermatol. 2003;28:123–7.

    Article  CAS  PubMed  Google Scholar 

  3. Yosipovitch G, Rechavia E, Feinmesser M, David M. Adverse cutaneous reactions to ticlopidine in patients with coronary stents. J Am Acad Dermatol. 1999;41:473–6.

    Article  CAS  PubMed  Google Scholar 

  4. Khambekar SK, Kovac J, Gershlick AH. Clopidogrel induced urticarial rash in a patient with left main stem percutaneous coronary intervention: management issues. Heart. 2004;90:e14.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Gowda RM, Misra D, Khan IA. Hypersensitivity skin rash: an adverse drug reaction to clopidogrel loading dose. Int J Cardiol. 2004;95:333.

    Article  PubMed  Google Scholar 

  6. Cheema AN, Mohammad A, Hong T, Jakubovic HR, Parmar GS, Sharieff W, et al. Characterization of clopidogrel hypersensitivity reactions and management with oral steroids without clopidogrel discontinuation. J Am Coll Cardiol. 2011;58:1445–54.

    Article  CAS  PubMed  Google Scholar 

  7. Báez-Montiel BB, Gutiérrez-Islas E, Herrera-Ontañón JR, Turabián JL. To enlighten and to dazzle: a case of an inadequate prescription of prasugrel with an adverse reaction of urticaria. Aten Primaria. 2013;45:64–5.

    Article  PubMed  Google Scholar 

  8. Berkes EA. Anaphylactic and anaphylactoid reactions to aspirin and other NSAIDs. Clin Rev Allergy Immunol. 2003;24:137–48.

    Article  CAS  PubMed  Google Scholar 

  9. Pharand C, Palisaitis DA, Hamel D. Potential anaphylactic shock with abciximab readministration. Pharmacotherapy. 2002;22:380–3.

    Article  PubMed  Google Scholar 

  10. Angelides S, Van der Wall H, Freedman SB. Acute reaction to dipyridamole during myocardial scintigraphy. N Engl J Med. 1999;340:394.

    Article  CAS  PubMed  Google Scholar 

  11. Blanca M, Perez E, Garcia JJ, Miranda A, Terrados S, Vega JM, Suau R. Angioedema and IgE antibodies to aspirin: a case report. Ann Allergy. 1989;62:295–8.

    CAS  PubMed  Google Scholar 

  12. Makkar K, Wilensky RL, Julien MB, Herrmann HC, Spinler SA. Rash with both clopidogrel and ticlopidine in two patients following percutaneous coronary intervention with drug-eluting stents. Ann Pharmacother. 2006;40:1204–7.

    Article  PubMed  Google Scholar 

  13. Yang DC, Feldman DN, Kim LK, Minutello RM, Bergman G, Wong SC, Swaminathan RV. A strategy of ‘treating through’ a prasugrel-induced rash. Int J Cardiol. 2013;168:4381–2.

    Article  PubMed  Google Scholar 

  14. Raccah BH, Shalit M, Danenberg HD. Allergic reaction to prasugrel and cross-reactivity with clopidogrel. Int J Cardiol. 2012;157:e48–9.

    Article  PubMed  Google Scholar 

  15. Nanau RM, Delzor F, Neuman MG. Efficacy and safety of Prasugrel in acute coronary syndrome patients. Clin Biochem. 2014;47:516–28. doi:10.1016/j.clinbiochem.2014.03.005.

    Article  CAS  PubMed  Google Scholar 

  16. Lokhandwala JO, Best PJ, Butterfield JH, Skelding KA, Scott T, Blankenship JC, et al. Frequency of allergic or hematologic adverse reactions to ticlopidine among patients with allergic or hematologic adverse reactions to clopidogrel. Circ Cardiovasc Interv. 2009;2:348–51.

    Article  PubMed  Google Scholar 

  17. Owen P, Garner J, Hergott L, Page 2nd RL. Clopidogrel desensitization: case report and review of published protocols. Pharmacotherapy. 2008;28:259–70.

    Article  CAS  PubMed  Google Scholar 

  18. Tamura T, Sakaeda T, Kadoyama K, Okuno Y. Aspirin- and clopidogrel-associated bleeding complications: data mining of the public version of the FDA adverse event reporting system, AERS. Int J Med Sci. 2012;9:441–6. doi:10.7150/ijms.4549.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Bennett CL, Davidson CJ, Raisch DW, Weinberg PD, Bennett RH, Feldman MD. Thrombotic thrombocytopenic purpura associated with ticlopidine in the setting of coronary artery stents and stroke prevention. Arch Intern Med. 1999;159:2524–8.

    Article  CAS  PubMed  Google Scholar 

  20. Paradiso-Hardy FL, Angelo CM, Lanctot KL, Cohen EA. Hematologic dyscrasia associated with ticlopidine therapy: evidence for causality. CMAJ. 2000;163:1463–4.

    Google Scholar 

  21. Briguori C, Manganelli F, Picardi M, Villari B, Ricciardelli B. Thrombocytopenia and purpura-like lesions associated with clopidogrel. Ital Heart J. 2001;2:935–7.

    CAS  PubMed  Google Scholar 

  22. Bennett CL, Connors JM, Carwile JM, Moake JL, Bell WR, Tarantolo SR, et al. Thrombotic thrombocytopenic purpura associated with clopidogrel. N Engl J Med. 2000;342:1773–7.

    Article  CAS  PubMed  Google Scholar 

  23. Merlini PA, Rossi M, Menozzi A, Buratti S, Brennan DM, Moliterno DJ, et al. Thrombocytopenia caused by abciximab or tirofiban and its association with clinical outcome in patients undergoing coronary stenting. Circulation. 2004;109:2203–6.

    Article  CAS  PubMed  Google Scholar 

  24. Graidis C, Golias C, Dimitriadis D, Dimitriadis G, Bitsis T, Dimitrelos I, et al. Eptifibatide-induced acute profound thrombocytopenia: a case report. BMC Res Notes. 2014;7:107.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Jacob S, Dunn BL, Qureshi ZP, Bandarenko N, Kwaan HC, Pandey DK, et al. Ticlopidine-, clopidogrel-, and prasugrel-associated thrombotic thrombocytopenic purpura: a 20-year review from the Southern Network on Adverse Reactions (SONAR). Semin Thromb Hemost. 2012;38:845–53.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Frishman WH, Brosnan BD, Grossman M, Dasgupta D, Sun DK. Adverse dermatologic effects of cardiovascular drug therapy: part III. Cardiol Rev. 2002;10:337–48.

    Article  PubMed  Google Scholar 

  27. Tsuda T, Okamoto Y, Sakaguchi R, Katayama N, Hara I, Hayashi H, Ota K. Purpura due to aspirin-induced platelet dysfunction aggravated by drinking alcohol. J Int Med Res. 2001;29:374–80.

    Article  CAS  PubMed  Google Scholar 

  28. Dogra S, Kanwar AJ. Clopidogrel bisulphate-induced photosensitive lichenoid eruption: first report. Br J Dermatol. 2003;148:609–10.

    Article  CAS  PubMed  Google Scholar 

  29. Kurokawa I, Umehara M, Nishijima S. Lichen planus-type drug eruption resulting from ticlopidine. Int J Dermatol. 2005;44:436–7.

    Article  PubMed  Google Scholar 

  30. Ruiz Villaverde R, Blasco Melguizo J, Mendoza Guil F, Martin Sanchez MC, Naranjo Sintes R. Generalized lichen planus-like eruption due to acetylsalicylic acid. J Eur Acad Dermatol Venereol. 2003;17:470–2.

    Article  CAS  PubMed  Google Scholar 

  31. Guijarro Guijarro B, Lopez Sanchez AF. Lichenoid reaction caused by clopidogrel, a new anti-platelet drug. Med Oral. 2003;8:33–7.

    PubMed  Google Scholar 

  32. Braun-Moscovici Y, Schapira D, Balbir-Gurman A, Sevilia R, Nahir AM. Ticlopidine-induced lupus. J Clin Rheumatol. 2001;7:102–5.

    Article  CAS  PubMed  Google Scholar 

  33. Yokoyama T, Usui T, Kiyama K, Nakashima R, Yukawa N, Kawabata D, et al. Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men. Mod Rheumatol. 2010;20:405–9.

    Article  PubMed  Google Scholar 

  34. Spiera RF, Berman RS, Werner AJ, Spiera H. Ticlopidine-induced lupus: a report of 4 cases. Arch Intern Med. 2002;162:2240–3.

    Article  PubMed  Google Scholar 

  35. Reich A, Bialynicki-Birula R, Szepietowski JC. Drug-induced subacute cutaneous lupus erythematosus resulting from ticlopidine. Int J Dermatol. 2006;45:1112–4.

    Article  PubMed  Google Scholar 

  36. Doogue MP, Begg EJ, Bridgman P. Clopidogrel hypersensitivity syndrome with rash, fever, and neutropenia. Mayo Clin Proc. 2005;80:1368–70.

    Article  PubMed  Google Scholar 

  37. Comert A, Akgun S, Civelek A, Kavala M, Sarigul S, Yildirim T, Arsan S. Clopidogrel-induced hypersensitivity syndrome associated with febrile pancytopenia. Int J Dermatol. 2005;44:882–4.

    Article  PubMed  Google Scholar 

  38. Ceylan C, Kirimli O, Akarsu M, Undar B, Güneri S. Early ticlopidine-induced hepatic dysfunction, dermatitis and irreversible aplastic anemia after coronary artery stenting. Am J Hematol. 1998;59:260.

    Article  CAS  PubMed  Google Scholar 

  39. Kawakami T, Fujita A, Takeuchi S, Muto S, Soma Y. Drug-induced hypersensitivity syndrome: drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome induced by aspirin treatment of Kawasaki disease. J Am Acad Dermatol. 2009;60:146–9.

    Article  PubMed  Google Scholar 

  40. Wolf I, Mouallem M, Rath S, Farfel Z. Clopidogrel-induced systemic inflammatory response syndrome. Mayo Clin Proc. 2003;78:618–20.

    Article  PubMed  Google Scholar 

  41. Ting HC, Adam BA. Stevens-Johnson syndrome. A review of 34 cases. Int J Dermatol. 1985;24:587–91.

    Article  CAS  PubMed  Google Scholar 

  42. Strippoli D, Russo G, Simonetti V, Motolese A. Lyell syndrome due to ticlopidine. G Ital Dermatol Venereol. 2011;146:497–500.

    CAS  PubMed  Google Scholar 

  43. Kaufman DW, Kelly JP. Acetylsalicylic acid and other salicylates in relation to Stevens-Johnson syndrome and toxic epidermal necrolysis. Br J Clin Pharmacol. 2001;51:174–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  44. Garcia CM, Carmena R, Garcia R, Berges P, Camacho E, Cotter MP, de la Hoz B. Fixed drug eruption from ticlopidine, with positive lesional patch test. Contact Dermatitis. 2001;44:40–1.

    Article  CAS  PubMed  Google Scholar 

  45. Ghosh SK, Bandyopadhyay D. Clopidogrel-induced fixed drug eruption. J Eur Acad Dermatol Venereol. 2009;23:1202–3.

    Article  CAS  PubMed  Google Scholar 

  46. Chan HL. Fixed drug eruptions. A study of 20 occurrences in Singapore. Int J Dermatol. 1984;23:607–9.

    Article  CAS  PubMed  Google Scholar 

  47. Pintor E, Sanmartin M, Azcona L, Hernandez R, Fernandez-Cruz A, Macaya C. Leukocytoclastic vasculitis associated with ticlopidine. Rev Esp Cardiol. 2001;54:114–6.

    Article  CAS  PubMed  Google Scholar 

  48. Erpolat S, Nazli Y, Colak N, Yenidunya S. Leucocytoclastic vasculitis associated with clopidogrel. Cutan Ocul Toxicol. 2012;31:171–3.

    Article  CAS  PubMed  Google Scholar 

  49. Shetty RK, Madken M, Naha K, Vivek G. Leucocytoclastic vasculitis as a late complication of clopidogrel therapy. BMJ Case Rep. 2013;17:2013.

    Google Scholar 

  50. Ballmer-Weber BK, Widmer M, Burg G. Acetylsalicylic acid-induced generalized pustulosis. Schweiz Med Wochenschr. 1993;123:542–6.

    CAS  PubMed  Google Scholar 

  51. Ellerbroek JC, Cleveland MG. Clopidogrel-associated acute generalized exanthematous pustulosis. Cutis. 2011;87:181–5.

    PubMed  Google Scholar 

  52. Cannavo SP, Borgia F, Guarneri F, Vaccaro M. Acute generalized exanthematous pustulosis following use of ticlopidine. Br J Dermatol. 2000;142:577–8.

    Article  CAS  PubMed  Google Scholar 

  53. Phillips EJ, Knowles SR, Shear NH. Serum sickness-like reaction associated with clopidogrel. Br J Clin Pharmacol. 2003;56:583.

    Article  PubMed Central  PubMed  Google Scholar 

  54. Dakik HA, Salti I, Haidar R, Uthman IW. Drug points: ticlopidine associated with acute arthritis. BMJ. 2002;324:27.

    Article  PubMed Central  PubMed  Google Scholar 

  55. Sugita K, Koga C, Yoshiki R, Izu K, Tokura Y. Papuloerythroderma caused by aspirin. Arch Dermatol. 2006;142:792–3.

    Article  PubMed  Google Scholar 

  56. Salava A, Alanko K, Hyry H. Dipyridamole-induced eczematous drug eruption with positive patch test reaction. Contact Dermatitis. 2012;67:103–4.

    Article  PubMed  Google Scholar 

  57. Meissner M, Beier C, Wolter M, Kaufmann R, Gille J. Suberythrodermic pustular psoriasis induced by clopidogrel. Br J Dermatol. 2006;155:630–1.

    Article  CAS  PubMed  Google Scholar 

  58. Mahajan VK, Khatri G, Prabha N, Abhinav C, Sharma V. Clopidogrel: a possible exacerbating factor for psoriasis. Indian J Pharmacol. 2014;46:123–4.

    Article  PubMed Central  PubMed  Google Scholar 

  59. Wu S, Han J, Qureshi AA. Use of aspirin, nonsteroidal anti-inflammatory drugs, and aceta-minophen (paracetamol), and risk of psoriasis and psoriatic arthritis: A Cohort Study. Acta Derm Venereol. 2014. doi:10.2340/00015555-1855.

    Google Scholar 

  60. Hsi DH, Mock DJ, Rocco Jr TA. Toxic erythroderma due to ticlopidine. N Engl J Med. 1999;340:1212.

    Article  CAS  PubMed  Google Scholar 

  61. Durdu M, Baba M, Seçkin D. A case of bullous pemphigoid induced by aspirin. J Am Acad Dermatol. 2011;65:443–4.

    Article  PubMed  Google Scholar 

  62. Maron F. Mucosal burn resulting from chewable aspirin: report of case. J Am Dent Assoc. 1989;119:279–80.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology and Venereology, Istanbul University Istanbul Medical Faculty, Istanbul, Turkey

    Esen Özkaya & Kurtuluş Didem Yazganoğlu

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  1. Esen Özkaya
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  2. Kurtuluş Didem Yazganoğlu
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Özkaya, E., Yazganoğlu, K.D. (2014). Platelet Inhibitors. In: Adverse Cutaneous Drug Reactions to Cardiovascular Drugs. Springer, London. https://doi.org/10.1007/978-1-4471-6536-1_12

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  • DOI: https://doi.org/10.1007/978-1-4471-6536-1_12

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