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The Coronary Circulation in Cardiomyopathies and Cardiac Allografts

Effect of Specific Pathologies on Epicardial Vessels and the Microcirculation

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Physiological Assessment of Coronary Stenoses and the Microcirculation

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Abstract

Cardiomyopathies are a collection of diseases that encompass a broad range of diverse dentities all of which affect the structure of the myocardium.

Coronary microvascular dysfunction (CMD) can occur in cardiomyopathies in the absence of epicardial coronary artery disease. Furthermore, CMD has also been implicated in posttransplantation cardiac allograft vasculopathy (CAV). Although myocardial blood flow (MBF) abnormalities related to CMD have important prognostic implications in both scenarios, pathophysiological mechanisms differ between cardiomyopathies and CAV. To date, CMD is fully accepted in the pathogenesis of HCM and CAV, but some doubts remain for the role of CMD in DCM and other myocardial diseases. In this chapter, we review current knowledge about CMD in cardiomyopathies and CAV.

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  1. Imperial College, London, UK

    Christopher J. Broyd

  2. Hospital Universitario Puerta de Hierro, Madrid, Spain

    Fernando Dominguez & Pablo Garcia-Pavia

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  1. Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain

    Javier Escaned

  2. Imperial College London, London, United Kingdom

    Justin Davies

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Broyd, C.J., Dominguez, F., Garcia-Pavia, P. (2017). The Coronary Circulation in Cardiomyopathies and Cardiac Allografts. In: Escaned, J., Davies, J. (eds) Physiological Assessment of Coronary Stenoses and the Microcirculation. Springer, London. https://doi.org/10.1007/978-1-4471-5245-3_9

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