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Benefits and Risks of Different Regimen of Intermittent Hypoxic Training

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Intermittent Hypoxia and Human Diseases

Abstract

Intermittent hypoxia could effectively stimulate various metabolic processes, and this ­phenomenon is increasingly used in sport and medicine practice. However, the mode of intermittent hypoxia training (IHT) is important for achieving adequate protective effects. It is known that the short and chronic intermittent hypoxia may have serious pathophysiological consequences in organism’s tissues, depending on severity and duration of the hypoxia insult. This chapter investigates the effects of various modes of IHT differing by the intensity and duration of hypoxic exposure on morphology and antioxidant status of the heart and lung tissues. The results showed that the IHT mode with more severe but shorter hypoxic component led to the prooxidant/antioxidant imbalance in the myocardial and lung tissues, which was accompanied with significant disorders in their morphology and ­function. Moderate hypoxic exposure of different durations promoted the maintenance of optimal antioxidant homeostasis and development of compensatory adaptive changes in tissue structure.

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Abbreviations

IHT:

Intermittent hypoxic training

LPO:

Lipid peroxidation

RTLF:

Respiratory tract lining fluid

TBARS:

Thiobarbituric acid-reactive substances

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Authors and Affiliations

  1. Department of Hypoxia, Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine

    Katerina Rozova, Olga Gonchar & Iryna N. Mankovska

Authors
  1. Katerina Rozova
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  2. Olga Gonchar
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  3. Iryna N. Mankovska
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Corresponding author

Correspondence to Katerina Rozova .

Editor information

Editors and Affiliations

  1. , Division of Cardiology, Virginia Commonwealth University, Richmond, 23298, Virginia, USA

    Lei Xi

  2. Bogomoletz Institute of Physiology, Kiev, 01601, Ukraine

    Tatiana V. Serebrovskaya

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© 2012 Springer-Verlag London

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Rozova, K., Gonchar, O., Mankovska, I.N. (2012). Benefits and Risks of Different Regimen of Intermittent Hypoxic Training. In: Xi, L., Serebrovskaya, T. (eds) Intermittent Hypoxia and Human Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-2906-6_22

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  • DOI: https://doi.org/10.1007/978-1-4471-2906-6_22

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  • Print ISBN: 978-1-4471-2905-9

  • Online ISBN: 978-1-4471-2906-6

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