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Cardiomyopathies and Heart Failure pp 83–96Cite as

Anti-G-Protein-Coupled Cardiac Receptor Autoantibodies in Dilated Cardiomyopathy

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 248))

Abstract

Idiopathic dilated cardiomyopathy (DCM) is an enigmatic disease, one of the leading causes of severe heart failure in younger adults, and the most common cause of heart transplantation due to ventricular dilatation and contractile dysfunction. DCM is familial in 20% of cases, while 80% are sporadic. The clinical impact of DCM is far greater than may be suspected from its epidemiology. Despite recent therapeutic improvements, its incidence and associated mortality remain very high, and its heterogeneous etiology represents a major challenge. Thus far, three potentially important factors have been identified, including enteroviral infections, immune mechanisms, and genetic factors. It is plausible that a subset of DCM has post-infectious autoimmune etiology, especially in individuals with genetic predispositions. In the last 10 years, several studies have shown the presence of distinct autoantibodies, or other immune factors, in heterogeneous subsets of DCM, which have contributed both supportive and confounding evidence to the hypothesis that multiple autoimmune mechanisms are involved in DCM. This chapter discusses our understanding of these autoimmune mechanisms, with a focus on anti-G-protein-coupled receptor autoantibodies in DCM.

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Authors and Affiliations

  1. Wallenberg Laboratory, Sahlgrenska University Hospital, SE-413 45, Göteborg, Sweden

    Michael Fu MD, PhD

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  1. Michael Fu MD, PhD
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Editors and Affiliations

  1. Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Akira Matsumori MD, PhD

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Fu, M. (2003). Anti-G-Protein-Coupled Cardiac Receptor Autoantibodies in Dilated Cardiomyopathy. In: Matsumori, A. (eds) Cardiomyopathies and Heart Failure. Developments in Cardiovascular Medicine, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9264-2_8

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  • DOI: https://doi.org/10.1007/978-1-4419-9264-2_8

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