Abstract
There is increasing evidence that the modulation of intracellular redox states has important implications in cellular events, such as proliferation and apoptosis via the regulation of intracellular signal transduction and gene expression. Thioredoxin (TRX) is a multifunctional stress-inducible protein, which protects cells from various types of stresses. TRX has not only a scavenging activity of ROS, but also a regulating activity of various intracellular molecules including transcription factors. We showed that overexpression of human TRX in transgenic (TRX-TG) mice prolonged the life span and had a protective effect against postischemic reperfusion injury in the brain, and against bleomycin- or cytokine-induced interstitial pneumonia.
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Shioji, K., Nakamura, H., Kishimoto, C., Yuan, Z., Yodoi, J. (2003). Protection of Cell Injury by Thioredoxin. In: Matsumori, A. (eds) Cardiomyopathies and Heart Failure. Developments in Cardiovascular Medicine, vol 248. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9264-2_34
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DOI: https://doi.org/10.1007/978-1-4419-9264-2_34
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