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Evidence for the Participation of Poly(ADPribosyl)ation in Collagenase Gene Expression in Rabbit Synovial Fibroblasts after Treatment with Active Oxygen Released by Xanthin/Xanthinoxidase

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ADP-Ribosylation Reactions

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Abstract

Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation. In this disease the membrane (synovium) that lines the joint proliferates into a huge mass that invades and destroys the connective tissues, i.e. articular cartilage, tendon and bone (1). It is suggested that this is a tumor like process which is induced by the combined action of autoantigen stimulated polymorphonuclear leukocytes, T and B cells, and monocytes/macrophages (1, 2, 3). The proliferating tissue is compromised primarily of the fibroblast-like synovial cells that line the joint and that are derived from mesenchymal stem cells (1). The neutral proteinase collagenase is a principle gene product of the synovial fibroblasts and is responsible for the extensive amount of connective tissue destruction seen in rheumatoid disease (1, 4-7).

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Author information

Authors and Affiliations

  1. Robert Koch-Institut, Abt. Biochemie, Nordufer 20, Berlin 65, D-1000, Germany

    Wilhelm Ehrlich, Hans Huser & Hans Kröger

Authors
  1. Wilhelm Ehrlich
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  2. Hans Huser
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  3. Hans Kröger
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Editor information

Editors and Affiliations

  1. Centre de Recherches en Endocrinologie Moleculaire, Le Centre Hospitalier de l’Universite Laval, Quebec, G1V 4G2, Canada

    Guy G. Poirier

  2. Biochemistry Department Pavillon Vachon, Universite Laval, Quebec, G1K 7P4, Canada

    Pierre Moreau

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© 1992 Springer Science+Business Media New York

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Ehrlich, W., Huser, H., Kröger, H. (1992). Evidence for the Participation of Poly(ADPribosyl)ation in Collagenase Gene Expression in Rabbit Synovial Fibroblasts after Treatment with Active Oxygen Released by Xanthin/Xanthinoxidase. In: Poirier, G.G., Moreau, P. (eds) ADP-Ribosylation Reactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8718-1_34

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  • DOI: https://doi.org/10.1007/978-1-4419-8718-1_34

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6456-9

  • Online ISBN: 978-1-4419-8718-1

  • eBook Packages: Springer Book Archive

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