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Hox Genes pp 155–165Cite as

Homeosis and Beyond. What Is the Function of the Hox Genes?

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 689))

Abstract

What is the function of the Hox genes? At first glance, it is a curious question. Indeed, the answer seems so obvious that several authors have spoken of ‘the Hox function’ about some of the Hox genes, namely Hox3/zen and Hox6/ftz that seem to have lost it during the evolution of Arthropods. What these authors meant is that these genes have lost their ‘homeotic’ function. Indeed, ‘homeotic’ refers to a functional property that is so often associated with the Hox genes. However, the word ‘Hox’ should not be used to refer to a function, but to a group of genes. The above examples of Hox3/zen (see Schmitt-Ott’s chapter, this book) and Hox6/ ftz show that the homeotic function may be not so tightly linked to the Hox genes. Reversely, many genes, not belonging to the Hox group, do present a homeotic function.

In the present chapter, I will first give a definition of the Hox genes. I will then ask what is the ‘function’ of a gene, examining its various meanings at different levels of biological organization. I will review and revisit the relation between the Hox genes and homeosis. I will suggest that their morphological homeotic function has been secondarily derived during the evolution of the Bilateria.

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Authors and Affiliations

  1. Developmental Biology, Pierre and Marie Curie University, Paris, France

    Jean S. Deutsch (Emeritus Professor)

  2. CNRS, UMR 7622 Biologie du développement, Université P. and M. Curie (Paris 6), Paris, France

    Jean S. Deutsch (Emeritus Professor)

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  1. Developmental Biology, Pierre and Marie Curie University, Paris, France

    Jean S. Deutsch PhD

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Deutsch, J.S. (2010). Homeosis and Beyond. What Is the Function of the Hox Genes?. In: Deutsch, J.S. (eds) Hox Genes. Advances in Experimental Medicine and Biology, vol 689. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6673-5_12

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