Summary
In this study DAB was shown to be mutagenic to S. typhimurium TA1538. Demonstration of this activity depended on the presence of an S9 mix prepared from Aroclor 1254-induced rat liver; no activity was seen in tests using non-induced mouse liver S9 mixes. Varying the concentration of S9 in the final mix over an approximately tenfold range had little effect on the assay. No evidence of mutagenic activity was seen in tests with CDA.
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Notes
Ames, B.N., Lee, F.D., and Durston, W.E. (1973a). An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc. Natl. Acad. Sci. (USA), 70: 782–786
Ames, B.N., Durston, W.E., Yamasaki, E. and Lee, F.D. (1973b). Carcinogens are mutagens: A simple test combining liver homogenate for activation and bacteria for detection. Proc. Natl. Acad. Sci. (USA), 70: 2281–2285
Ames, B.N., McCann, J. and Yamasaki, E. (1975). Methods for detecting carcinogens and mutagens with the Salmonella/ mammalian-microsome mutagenicity test. Mutation Res. 31: 347–364
Lefevre, P.A. and Ashby, J. (1981). The effect of preincubation period and norharman on the mutagenic potency of 4-dimethyl-aminoazobenzene and 3-methyl-4-dimethylaminoazobenzene in S. typhimurium. Carcinogenesis 2: 927–931
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© 1985 United Kingdom Environmental Mutagen Society
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Ladner, A., Furlong, J.W. (1985). 4-Dimethylaminoazobenzene (DAB) and 4-Cyanodimethylaniline (CDA): Reverse Mutation Tests with Salmonella typhimurium TA1538. In: Parry, J.M., Arlett, C.F. (eds) Comparative Genetic Toxicology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07901-8_8
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DOI: https://doi.org/10.1007/978-1-349-07901-8_8
Publisher Name: Palgrave Macmillan, London
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