Summary
All four compounds BZD, DAT, DAB and CDA (Sample A) were mutagenic when tested in S. typhimurium TA 1538 with metabolic activation. The standard Aroclor-induced rat S9 was compared with DDT-induced rat and 3-methylcholanthrene (MC)-induced guinea pig S9, the latter producing the greatest numbers of revertants per microgram of BZD, DAT and CDA. DAB had the weakest mutagenic activity, demonstrable only with rat-Aroclor and guinea pig-MC S9. DAT was the only compound which was active in the absence of metabolic activation.
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Notes
Ames, B.N., McCann, J. and Yamasaki, E. (1975). Methods for detecting carcinogens and mutagens with the Salmonella/ mammalian-microsome mutagenicity test. Mutation Res. 31: 347–364
Baker, R.S.U., Bonin, A.M., Stupans, I. and Holder, G.M. (1980). Comparison of rat and guinea pig as sources of the S9 fraction in the Salmonella/mammalian-microsome mutagenicity test. Mutation Res. 71: 43–52
Moore, D. and Felton, J.S. (1983). A microcomputer program for analysing Ames test data. Mutation Res. 119: 95–102
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© 1985 United Kingdom Environmental Mutagen Society
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Baker, R.S.U., Bonin, A.M. (1985). Salmonella Mutagenicity Testing of Benzidine, 4,4″-Diaminoterphenyl, 4-Dimethylaminoazobenzene and 4-Cyanodimethylaniline Using three Different S9 Preparations. In: Parry, J.M., Arlett, C.F. (eds) Comparative Genetic Toxicology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07901-8_4
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DOI: https://doi.org/10.1007/978-1-349-07901-8_4
Publisher Name: Palgrave Macmillan, London
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