Abstract
A one year carcinogenicity study in Fischer F344 rats (Eldridge et al., this volume) has indicated that benzidine (BZD) induces primarily liver tumours whereas 4,4″-diaminoterphenyl (DAT) induces Zymbal’s gland tumours. Evidence from bacterial mutagenicity studies (Garner et al. 1975; Morton et al., 1979) and from DNA binding studies (Kennelly et al., 1984a) suggests that for BZD the ultimate carcinogenic moiety is not BZD itself but an activated form of the compound after metabolism.
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© 1985 United Kingdom Environmental Mutagen Society
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Paes, D., Gatehouse, D., Tweats, D. (1985). A Comparison of the Mutagenicity of Benzidine and 4,4″-Diaminoterphenyl with Uninduced Mouse and Rat Liver S9. In: Parry, J.M., Arlett, C.F. (eds) Comparative Genetic Toxicology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07901-8_10
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DOI: https://doi.org/10.1007/978-1-349-07901-8_10
Publisher Name: Palgrave Macmillan, London
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