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Adenosine as a Putative Mediator in Asthma: Its Role in Bronchoconstriction and Modulation of Histamine Release from Human Lung Mast Cells and Basophil Leucocytes

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Abstract

Bronchial asthma is characterized physiologically by increased airways reactivity to specific and non-specific stimulation and pathologically by endobronchial inflammation. The inflammatory response in and around the airways results from the release of preformed and newly generated mast cell-associated mediators with the recruitment of secondary effector cells such as eosinophils, neutrophils and monocytes into the area of inflammation.

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Authors
  1. M. K. Church
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  2. R. C. Benyon
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  3. P. J. Hughes
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  4. M. J. Cushley
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  5. J. S. Mann
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  6. S. T. Holgate
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Editor information

Editors and Affiliations

  1. Department of Physiology, St George’s Hospital Medical School, SW17 0RE, London, UK

    T. W. Stone

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© 1985 The Contributors

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Church, M.K., Benyon, R.C., Hughes, P.J., Cushley, M.J., Mann, J.S., Holgate, S.T. (1985). Adenosine as a Putative Mediator in Asthma: Its Role in Bronchoconstriction and Modulation of Histamine Release from Human Lung Mast Cells and Basophil Leucocytes. In: Stone, T.W. (eds) Purines. Satellite Symposia of the IUPHAR 9th International Congress of Pharmacology. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-07564-5_18

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