Skip to main content
SpringerLink
Log in

Musculoskeletal Involvement

  • Chapter
  • First Online:
Sjögren’s Syndrome

  • 1221 Accesses

Abstract

Musculoskeletal manifestations such as myalgias, arthralgias, an intermittent non-erosive mild polyarthritis affecting mainly small joints, are common in patients with primary Sjögren’s syndrome. Myositis may also occur but much less frequently. The most important features of these manifestations are described in this chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Pertovaara M, Pukkala E, Laippala P, et al. A longitudinal cohort study of Finnish patients with primary Sjögren’s syndrome: clinical, immunological, and epidemiological aspects. Ann Rheum Dis. 2001;60:467–72.

    Article  PubMed  CAS  Google Scholar 

  2. Ioannidis J, Vassiliou V, Moutsopoulos H. Long-term risk of mortality and lymphoproliferative disease and predictive classification of primary Sjögren’s syndrome. Arthritis Rheum. 2002;46:741–7.

    Article  PubMed  Google Scholar 

  3. Theander E, Manthorpe R, Jacobsson L. Mortality and causes of death in primary Sjögren’s syndrome: a prospective cohort study. Arthritis Rheum. 2004;50:1262–9.

    Article  PubMed  Google Scholar 

  4. Alamanos Y, Tsifetaki N, Voulgari PV, Venetsanopoulou AI, et al. Epidemiology of primary Sjögren’s syndrome in north-west Greece, 1982–2003. Rheumatology (Oxford). 2006;45:187–91.

    Article  CAS  Google Scholar 

  5. Ramos-Casals M, Solans R, Rosas J, et al. Primary Sjögren syndrome in Spain: clinical and immunologic expression in 1010 patients. Medicine (Baltimore). 2008;87:210–9.

    Article  CAS  Google Scholar 

  6. Haga HJ, Peen E. A study of the arthritis pattern in primary Sjögren’s syndrome. Clin Exp Rheumatol. 2007;25:88–91.

    PubMed  Google Scholar 

  7. Kruize AA, Hené RJ, Van Der Heide A, et al. Long-term followup of patients with Sjögren’s syndrome. Arthritis Rheum. 1996;39:297–303.

    Article  PubMed  CAS  Google Scholar 

  8. Haga HJ, Jonsson R. The influence of age on disease manifestations and serological characteristics in primary Sjögren’s syndrome. Scand J Rheumatol. 1999;28:227–32.

    Article  PubMed  CAS  Google Scholar 

  9. Ramos-Casals M, Cervera R, Font J, et al. Young onset of primary Sjögren’s syndrome: clinical and immunological characteristics. Lupus. 1998;7:202–6.

    Article  PubMed  CAS  Google Scholar 

  10. García-Carrasco M, Cervera R, Rosas J, et al. Primary Sjögren’s syndrome in the elderly: clinical and immunological characteristics. Lupus. 1999;8:20–3.

    Article  PubMed  Google Scholar 

  11. Barrs DM, McDonald TJ, Duffy J. Sjögren’s syndrome involving the larynx: report of a case. J Laryngol Otol. 1979;93:933–6.

    Article  PubMed  CAS  Google Scholar 

  12. Sève P, Poupart M, Bui-Xuan C, et al. Cricoarytenoid arthritis in Sjögren’s syndrome. Rheumatol Int. 2005;25:301–2.

    Article  PubMed  Google Scholar 

  13. García-Carrasco M, Ramos-Casals M, Rosas J, et al. Primary Sjögren syndrome: clinical and immunologic disease patterns in a cohort of 400 patients. Medicine (Baltimore). 2002;81:270–80.

    Article  Google Scholar 

  14. Kamali S, Polat NG, Kasapoglu E, et al. Anti-CCP and antikeratin antibodies in rheumatoid arthritis, primary Sjögren’s syndrome, and Wegener’s granulomatosis. Clin Rheumatol. 2005;24:673–6.

    Article  PubMed  Google Scholar 

  15. Atzeni F, Sarzi-Puttini P, Lama N, et al. Anti-cyclic citrullinated peptide antibodies in primary Sjögren syndrome may be associated with non-erosive synovitis. Arthritis Res Ther. 2008;10:1–6.

    Article  Google Scholar 

  16. Papiris SA, Tsonis IA, Moutsopoulos HM. Sjögren’s syndrome. Semin Respir Crit Care Med. 2007;28:459–71.

    Article  PubMed  Google Scholar 

  17. Rehman HU. Sjögren’s syndrome. Yonsei Med J. 2003;44:947–54.

    PubMed  Google Scholar 

  18. Castro-Poltronieri A, Alarcón-Segovia D. Articular manifestations of primary Sjögren’s syndrome. J Rheumatol. 1983;10:485–8.

    PubMed  CAS  Google Scholar 

  19. Rantapaa-Dahlqvist SR, de Jong BA, Berglin E, et al. Antibodies against cyclic citrullinated peptides and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48:2741–9.

    Article  PubMed  Google Scholar 

  20. Gottenberg JE, Mignot S, Nicaise-Rolland P, et al. Prevalence of anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sjögren’s syndrome. Ann Rheum Dis. 2005;64:114–7.

    Article  PubMed  CAS  Google Scholar 

  21. Goëb V, Salle V, Duhaut P, et al. Clinical significance of autoantibodies recognizing Sjögren’s syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjögren’s syndrome. Clin Exp Immunol. 2007;148:281–7.

    Article  PubMed  Google Scholar 

  22. Cervera R, Khamashta MA, Font J, et al. Systemic lupus erythematosus: clinical and immunologic patterns of disease expression in a cohort of 1,000 patients. The European working party on systemic lupus erythematosus. Medicine (Baltimore). 1993;72:113–24.

    CAS  Google Scholar 

  23. Spilberg I, Siltzbach LE, McEwen C. The arthritis of sarcoidosis. Arthritis Rheum. 1969;12:126–37.

    Article  PubMed  CAS  Google Scholar 

  24. Petri MA. In: Koopman WJ, editor. Arthritis and allied conditions – a textbook of rheumatology. 14th ed. Philadelphia: Lippincott Williams & Wilkin; 2001. p. 1455–79.

    Google Scholar 

  25. Martinez-Lavin M, Vaughan JH, Tan EM. Autoantibodies and the spectrum of Sjögren’s syndrome. Ann Intern Med. 1979;91:185–90.

    PubMed  CAS  Google Scholar 

  26. Vitali C, Tavoni A, Neri R, et al. Fibromyalgia features in patients with primary Sjögren’s syndrome. Evidence of a relationship with psychological depression. Scand J Rheumatol. 1989;18:21–7.

    Article  PubMed  CAS  Google Scholar 

  27. Tishler M, Barak Y, Paran D, et al. Sleep disturbances, fibromyalgia and primary Sjögren’s syndrome. Clin Exp Rheumatol. 1997;15:71–4.

    PubMed  CAS  Google Scholar 

  28. Lindvall B, Bengtsson A, Ernerudh J, et al. Subclinical myositis is common in primary Sjögren’s syndrome and is not related to muscle pain. J Rheumatol. 2002;29:717–25.

    PubMed  Google Scholar 

  29. Alexander EL. Neuromuscular complications of primary Sjögren’s syndrome. In: Talal N, Moutsopoulos HM, Kassan SS, editors. Sjögren’s syndrome. Clinical and immunological aspects. Berlin: Springer; 1987. p. 61–82.

    Google Scholar 

  30. Chad D, Good P, Adelman L, et al. Inclusion body myositis associated with Sjögren’s syndrome. Arch Neurol. 1982;39:186–8.

    PubMed  CAS  Google Scholar 

  31. Gutmann L, Govindan S, Riggs JE, et al. Inclusion body myositis and Sjögren’s syndrome. Arch Neurol. 1985;42:1021–2.

    PubMed  CAS  Google Scholar 

  32. Khraishi MM, Jay V, Keystone EC. Inclusion body myositis in association with vitamin B12 deficiency and Sjögren’s syndrome. J Rheumatol. 1992;19:306–9.

    PubMed  CAS  Google Scholar 

  33. Vrethem M, Lindvall B, Holmgren H, et al. Neuropathy and myopathy in primary Sjögren’s syndrome: neurophysiological, immunological and muscle biopsy results. Acta Neurol Scand. 1990;82:126–31.

    Article  PubMed  CAS  Google Scholar 

  34. Kraus A, Cifuentes M, Villa AR, et al. Myositis in primary Sjögren’s syndrome. Report of 3 cases. J Rheumatol. 1994;21:649–53.

    PubMed  CAS  Google Scholar 

  35. Molina R, Provost TT, Arnett FC, et al. Primary Sjögren’s syndrome in men. Clinical, serologic, and immunogenetic features. Am J Med. 1986;80:23–31.

    Article  PubMed  CAS  Google Scholar 

  36. Ringel SP, Forstot JZ, Tan EM, et al. Sjögren’s syndrome and polymyositis or dermatomyositis. Arch Neurol. 1982;39:157–63.

    PubMed  CAS  Google Scholar 

  37. Layzer RB. Inflammatory and immune disorders. In: Layzer RB, editor. Neuromuscular manifestations of systemic disease. Philadelphia: Davis; 1985. p. 227–8.

    Google Scholar 

  38. Leroy JP, Drosos AA, Yiannopoulos DI, et al. Intravenous pulse cyclophosphamide therapy in myositis and Sjögren’s syndrome. Arthritis Rheum. 1990;33:1579–81.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic, Barcelona, Catalonia, Spain

    Guillermo J. Pons-Estel

  2. Division of Clinical Immunology and Rheumatology, Department of Medicine, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA

    Guillermo J. Pons-Estel & Graciela S. Alarcón

  3. Department of Rheumatology, Instituto Cardiovascular de Rosario, Rosario, Argentina

    Bernardo A. Pons-Estel

Authors
  1. Guillermo J. Pons-Estel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bernardo A. Pons-Estel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Graciela S. Alarcón
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Guillermo J. Pons-Estel .

Editor information

Editors and Affiliations

  1. Barcelona, Surgey, Hospital Clinic, Calle Villarroel, 170, Barcelona, 08036, Spain

    Manuel Ramos-Casals

  2. Massachusetts General Hospital, Boston, 02114, Massachusetts, USA

    John H. Stone

  3. National University of Athens, Athens, Greece

    Haralampos M. Moutsopoulos

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag London Limited

About this chapter

Cite this chapter

Pons-Estel, G.J., Pons-Estel, B.A., Alarcón, G.S. (2011). Musculoskeletal Involvement. In: Ramos-Casals, M., Stone, J., Moutsopoulos, H. (eds) Sjögren’s Syndrome. Springer, London. https://doi.org/10.1007/978-0-85729-947-5_10

Download citation

  • DOI: https://doi.org/10.1007/978-0-85729-947-5_10

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-0-85729-946-8

  • Online ISBN: 978-0-85729-947-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation