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The Cytochrome P450 Superfamily of Monooxygenases

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Handbook of Maize

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Cytochrome P450 monooxygenases (P450) are encoded by a superfamily of genes that is ubiquitously present in bacteria, animals and plants. Plants have many different P450s and use them for biosynthesis and for detoxification. Plant P450s function in primary and secondary metabolism and are involved in biosynthesis of hormons and signalling molecules.

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References

  • Bate NJ, S. Sivasankar, C. Moxon, J.M. Riley, J.E. Thompson and S.J. Rothstein (1998) Molecular characterization of an Arabidopsis gene encoding hydroperoxide lyase, a cytochrome P-450 that is wound inducible. Plant Physiol. 117:1393–400.

    Article  PubMed  CAS  Google Scholar 

  • Benveniste I., J.-P. Salün and F. Durst (1977) Wound-induced cinnamic acid hydroxylase in Jerusalem artichoke tuber. Phytochem 16:69–73.

    Article  CAS  Google Scholar 

  • Benveniste I., N. Tijet, F. Adas, G. Philipps, J.P. Salaun and F Durst (1998) CYP86A1 from Arabidopsis thaliana encodes a cytochrome P450-dependent fatty acid omega-hydroxylase. Biochem Biophys Res Commun. 243:688–93.

    Article  PubMed  CAS  Google Scholar 

  • Bernhardt R. (2006) Cytochromes P450 as versatile biocatalysts. J Biotechnol. 124:128–145.

    Article  PubMed  CAS  Google Scholar 

  • Bishop G.J., T. Nomura, T. Yokota, K. Harrison, T. Noguchi, S. Fujioka, S. Takatsuto, J.D. Jones and Y. Kamiya (1999) The tomato DWARF enzyme catalyzes C-6 oxidation in brassinosteroid biosynthesis. Proc Natl Acad Sci USA. 96:1761–1766.

    Article  PubMed  CAS  Google Scholar 

  • Bozak K.R., H. Yu, R. SirevÃ¥g and R.E. Christoffersen (1990) Sequence analysis of ripening-related cytochrome P-450 cDNAs from avocado fruit. Proc Natl Acad Sci U S A. 87:3904–3908.

    Article  PubMed  CAS  Google Scholar 

  • Croteau R., R.E.B. Ketchum, R.M. Long, R. Kaspera and M.R. Wildung (2006) Taxol biosynthesis and molecular genetics. Phytochem Rev 5:75–97

    Article  CAS  Google Scholar 

  • Dejong J.M., Y. Liu, A.P. Bollon, R.M. Long, S. Jennewein, D. Williams and R.B. Croteau RB. (2006) Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae. Biotechnol Bioeng. 93:212–224.

    Article  PubMed  CAS  Google Scholar 

  • Denisov I.G., T.M. Makris, S.G. Sligar and I. Schlichting (2005) Structure and chemistry of cytochrome P450. Chem Rev. 105:2253–2277.

    Article  PubMed  CAS  Google Scholar 

  • Duan H. and M.A. Schuler (2006) Heterologous expression and strategies for encapsulation of membrane-localized plant P450s. Phytochem Rev 5:507–523.

    Article  CAS  Google Scholar 

  • Frey M., P. Chomet, E. Glawischnig, C. Stettner, S. Grün, A. Winklmair, W. Eisenreich, A. Bacher, R.B. Meeley, S.P. Briggs, K. Simcox and A. Gierl (1997) Analysis of a chemical plant defense mechanism in grasses. Science 277:696–699.

    Article  PubMed  CAS  Google Scholar 

  • Hannemann F., A. Bichet, K.M. Ewen and R. Bernhardt R. (2007) Cytochrome P450 systems—biological variations of electron transport chains. Biochim Biophys Acta. 1770:330–344.

    PubMed  CAS  Google Scholar 

  • Helliwell C.A., C.C. Sheldon, M.R. Olive, A.R. Walker, J.A. Zeevaart, W.J. Peacock and E.S. Dennis (1998) Cloning of the Arabidopsis ent-kaurene oxidase gene GA3. Proc Natl Acad Sci U S A. 95:9019–9024.

    Article  PubMed  CAS  Google Scholar 

  • Helliwell C.A., P.M. Chandler, A. Poole, E.S. Dennis and W.J. Peacock (2001) The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway. Proc Natl Acad Sci U S A 98:2065–2070.

    Article  PubMed  CAS  Google Scholar 

  • Ketchum R.E., L. Wherland and R.B. Croteau (2007) Stable transformation and long-term maintenance of transgenic Taxus cell suspension cultures. Plant Cell Rep. 26:1025–1033.

    Article  PubMed  CAS  Google Scholar 

  • Kim J. and D. DellaPenna (2006) Defining the primary route for lutein synthesis in plants: the role of Arabidopsis carotenoid beta-ring hydroxylase CYP97A3. Proc Natl Acad Sci U S A. 103:3474–3479.

    Article  PubMed  CAS  Google Scholar 

  • Laudert D., U. Pfannschmidt, F. Lottspeich, H. Hollander-Czytko and E.W. Weiler. Cloning, molecular and functional characterization of Arabidopsis thaliana allene oxide synthase (CYP 74), the first enzyme of the octadecanoid pathway to jasmonates. Plant Mol Biol. 31:323–335.

    Google Scholar 

  • Li X., M.A. Schuler and M.R. Berenbaum MR. (2002) Jasmonate and salicylate induce expression of herbivore cytochrome P450 genes. Nature 419:712–5.

    Article  PubMed  CAS  Google Scholar 

  • Mizutani M, D. Ohta and R. Sato (1993) Purification and characterization of a cytochrome P450 (truns-cinnamic acid 4-hydroxylase) from etiolated mung bean seedlings. Plant Cell Physiol 34:481–488.

    CAS  Google Scholar 

  • Morant M., S. Bak, B.L.Moller and D. Werck-Reichhart (2003) Plant cytochromes P450: tools for pharmacology, plant protection and phytoremediation. Curr Opin Biotechnol. 14:151–162.

    Article  PubMed  CAS  Google Scholar 

  • Morikawa T.,M. Mizutani and D. Ohta (2006) Cytochrome P450 subfamily CYP710A genes encode sterol C-22 desaturase in plants. Biochem Soc Trans. 34:1202–1205.

    Article  PubMed  CAS  Google Scholar 

  • Nelson D.R. (2004) Cytochrome P450 nomenclature. Methods Mol Biol. 320:1–10.

    Google Scholar 

  • Nelson D.R., M.A. Schuler, S.M. Paquette, D. Werck-Reichhart and S. Bak (2004) Comparative genomics of rice and Arabidopsis. Analysis of 727 cytochrome P450 genes and pseudogenes from a monocot and a dicot. Plant Physiol. 135:756–772.

    Article  PubMed  CAS  Google Scholar 

  • Nelson D.R. (2006) Plant cytochrome P450s from moss to poplar. Phytochem Rev 5:193–204.

    Article  CAS  Google Scholar 

  • Persans M.W., J. Wang, M.A. Schuler (2001) Characterization of maize cytochrome P450 monooxy-genases induced in response to safeners and bacterial pathogens. Plant Physiol. 125:1126–38.

    Article  PubMed  CAS  Google Scholar 

  • Saito S., N. Hirai, C. Matsumoto, H. Ohigashi, D. Ohta, K. Sakata and M. Mizutani M. (2004) Arabidopsis CYP707As encode (+)-abscisic acid 8′-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid. Plant Physiol. 134:1439–1449.

    Article  PubMed  CAS  Google Scholar 

  • Schoch G., S. Goepfert, M. Morant, A. Hehn, D. Meyer, P. Ullmann and D. Werck-Reichhart (2001) CYP98A3 from Arabidopsis thaliana is a 3′-hydroxylase of phenolic esters, a missing link in the phenylpropanoid pathway. J Biol Chem. 276:36566–36574.

    Article  PubMed  CAS  Google Scholar 

  • Schuler, M.A., H. Duan, M. Bilgin and S. Ali (2006) Arabidopsis cytochrome P450s through the looking glass: a window on plant biochemistry. Phytochem Rev 5:205–237.

    Article  CAS  Google Scholar 

  • Sicker D, M. Frey, M. Schulzand A. Gierl (2000) Role of natural benzoxazinones in the survival strategy of plants. Int Rev Cytol. 198:319–46.

    Article  PubMed  CAS  Google Scholar 

  • Shimada Y., H. Goda, A. Nakamura, S. Takatsuto, S. Fujioka and S. Yoshida (2003) Organ-specific expression of brassinosteroid-biosynthetic genes and distribution of endogenous brassinosteroids in Arabidopsis. Plant Physiol. 131:287–97.

    Article  PubMed  CAS  Google Scholar 

  • Srere P.A. (1987) Complexes of sequential metabolic enzymes. Annu Rev Biochem 56:89–124

    Article  PubMed  CAS  Google Scholar 

  • Szekeres M., K. Nemeth, Z. Koncz-Kalman, J. Mathur, A. Kauschmann, T. Altmann, G.P. Redei, F. Nagy, J. Schell and C. Koncz C. (1996) Brassinosteroids rescue the deficiency of CYP90, a cytochrome P450, controlling cell elongation and de-etiolation in Arabidopsis. Cell 85:171–82.

    Article  PubMed  CAS  Google Scholar 

  • Takei K., T. Yamaya and H. Sakakibara H. (2004) Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin. J Biol Chem. 279:41866–41872.

    Article  PubMed  CAS  Google Scholar 

  • Tattersall D.B., S. Bak, P.R. Jones, C.E. Olsen, J.K. Nielsen, M.L. Hansen, P.B. Hoj and B.L. Moller (2001) Resistance to an herbivore through engineered cyanogenic glucoside synthesis. Science 293:1826–1828.

    Article  PubMed  CAS  Google Scholar 

  • Tian L., V. Musetti, J. Kim, M. Magallanes-Lundback and D. DellaPenna (2004) The Arabidopsis LUT1 locus encodes a member of the cytochrome P 450 family that is required for carotenoid epsilon-ring hydroxylation activity. Proc Natl Acad Sci U S A. 101:402–7.

    Article  PubMed  CAS  Google Scholar 

  • Turk E.M., S. Fujioka, H. Seto, Y. Shimada, S. Takatsuto, S. Yoshida, M.A. Denzel, Q.I. Torres and M.M. Neff MM. (2003) CYP72B1 inactivates brassinosteroid hormones: an intersection between photomorphogenesis and plant steroid signal transduction. Plant Physiol. 133:1643–1653.

    Article  PubMed  CAS  Google Scholar 

  • Turk E.M., S. Fujioka, H. Seto, Y. Shimada, S. Takatsuto, S. Yoshida, H. Wang, Q.I. Torres, J.M. Ward, G. Murthy, J. Zhang, J.C. Walker and M.M. Neff (2005) BAS1 and SOB7 act redundantly to modulate Arabidopsis photomorphogenesis via unique brassinosteroid inactivation mechanisms. Plant J. 42:23–34.

    Article  PubMed  CAS  Google Scholar 

  • Winkler RG and T Helentjaris (1995) The maize Dwarf3 gene encodes a cytochrome P450-mediated early step in Gibberellin biosynthesis. Plant Cell 7:1307–1317.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Alfons Gierl
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Editors and Affiliations

  1. Department of Genetics, University of Georgia, Athens, GA, 30602–7223, USA

    Jeffrey L. Bennetzen

  2. USDA Plant Gene Expression Center, 800 Buchanan Street, Albany, CA, 94710, USA

    Sarah Hake

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Gierl, A. (2009). The Cytochrome P450 Superfamily of Monooxygenases. In: Bennetzen, J.L., Hake, S. (eds) Handbook of Maize. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77863-1_37

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