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Baboon Model for Alcoholic Liver Disease: 1973–2003

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The Baboon in Biomedical Research

Alcoholism is a major public health problem in the United States. Alcoholic liver disease, especially its ultimate stage of scarring or cirrhosis, is responsible for 75% of all medical deaths due to alcohol and represents a major cause of mortality in urban areas (Lieber, 1992). However, development of adequate prevention and treatment has been hindered by the lack of a suitable experimental model.

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References

  • Arai, M., Leo, M. A., Nakano, M., Gordon, E. R., and Lieber, C. S. (1984a). Biochemical and morphological alterations of baboon hepatic mitochondria after chronic ethanol consumption. Hepatology 4:165–174.

    Google Scholar 

  • Arai, M., Gordon, E. R., and Lieber, C. S. (1984b). Decreased cytochrome oxidase activity in hepatic mitochondria after chronic ethanol consumption and the possible role of decreased cytochrome aa3 content and changes in phospholipids. Biochim. Biophys. Acta 797:320–327.

    Google Scholar 

  • Best, C. H., Hartroft, W. S., Lucas, C. C., and Ridout, J. H. (1949). Liver damage produced by feeding alcohol or sugar and its prevention by choline. Brit. Med. J. 2:1001–1006.

    Article  Google Scholar 

  • Bonnichsen, R. (1963). Ethanol. Determination with alcohol dehydrogenase and DPN. In: Bergmeyer, H.- U. (ed.), Methods of Enzymatic Analysis. Academic Press, New York, pp. 285–287.

    Google Scholar 

  • Chojkier, M., Houglum, K., Solis-Herruzo, J., and Brenner, D. A. (1989). Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblast. A role for lipid peroxidation? J. Biol. Chem. 264:16957–16962.

    CAS  PubMed  Google Scholar 

  • DeCarli, L. M., and Lieber, C. S. (1967). Fatty liver in the rat after prolonged intake of ethanol with a nutritionally adequate new liquid diet. J. Nutr. 91:331–336.

    CAS  PubMed  Google Scholar 

  • Duce, A.M., Ortiz, P., Cabrero, C., and Mato, J.M. (1988). S-adenosyl-l-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology 8:65–68.

    Article  CAS  PubMed  Google Scholar 

  • Ferenci, P., Dragosics, B., Dittrich, H., Frank, H., Benda, L., Lochs, H., Meryn, S., Base, W., and Schneider, B. (1989). Randomized controlled trial of silymarin-treatment in patients with cirrhosis of the liver. J. Hepatol. 9:105–113.

    Article  CAS  PubMed  Google Scholar 

  • Finkelstein, J.D., Cello, J.P., and Kyle, W.E. (1974). Ethanol-induced changes in methionine metabolism in rat liver. Biochem. Biophys. Res. Commun. 61:525–531.

    Article  CAS  PubMed  Google Scholar 

  • Foy, H., Kondi, A., and Mbaya, V. (1964). Effect of riboflavine deficiency on bone marrow function and protein metabolism in baboons. Preliminary Report. Br. J. Nutr. 18:307–318.

    Google Scholar 

  • Halliwell, B., and Gutteridge, J. M. C. (1989). Free Radicals in Biology and Medicine, 2nd ed. Clarendon Press, Oxford, pp. 188–214.

    Google Scholar 

  • Horowitz, J. H., Rypins, E. B., Henderson, J. M., Heymsfield, S. B., Moffitt, S. D., Bain, R. P., Chawla, R. K., Bleier, J. C., and Rudman, D. (1981). Evidence for impairment of transsulfuration pathway in cirrhosis. Gastroenterology 81:668–675.

    CAS  PubMed  Google Scholar 

  • Houglum, K., Filip, M., Witztun, J. L., and Chojkier, M. (1990). Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload. J. Clin. Invest. 86:1991–1998.

    Article  CAS  PubMed  Google Scholar 

  • Hummer, R. L. (1970). Observations of the feeding of baboons. In: Harris R. S. (ed.), Feeding and Nutrition of Nonhuman Primates. Academic Press, New York, pp. 183–203.

    Google Scholar 

  • Imai, Y., Ito, A., and Sato, R. (1966). Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. J. Biochem. 60:417–428.

    CAS  PubMed  Google Scholar 

  • Kinsell, L. W., Harper, H. A., Barton, H. C., Michaels, G. D., and Weiss, H. A. (1947). Rate of disappearance from plasma of intravenously administrated methionine in patients with liver damage. Science 106:589–594.

    Article  CAS  Google Scholar 

  • Lieber, C. S. (1988). The influence of alcohol on nutritional status. Nutr. Rev. 46:241–254.

    Article  CAS  PubMed  Google Scholar 

  • Lieber, C. S. (ed.). (1992). Medical and Nutritional Complications of Alcoholism: Mechanisms and Management. Plenum Medical Book Co., New York, pp. 579.

    Google Scholar 

  • Lieber, C. S. (2000). Alcoholic liver disease: New insights in pathogenesis lead to new treatments. J. Hepatol. 32:113–128.

    Article  CAS  PubMed  Google Scholar 

  • Lieber, C. S. (2001). Beneficial effects of polyenylphosphatidylcholine (PPC) in alcoholic and non-alcoholic liver injury. In: Leuschner, U., James, O., and Dancygier, H. (eds.), Steatohepatitis (NASH and ASH), Falk Symposium 121. Kluwer Academic Publishers, Dordrecht, pp. 343–361.

    Google Scholar 

  • Lieber, C. S., and DeCarli, L. M. (1970). Quantitative relationship between the amount of dietary fat and the severity of the alcoholic fatty liver. Am. J. Clin. Nutr. 23:474–478.

    CAS  PubMed  Google Scholar 

  • Lieber, C. S., and DeCarli, L. M. (1974). An experimental model of alcohol feeding and liver injury in the baboon. J. Med. Primatol. 3:153–163.

    CAS  PubMed  Google Scholar 

  • Lieber, C.S., and DeCarli, L. M. (1976). Animal models of ethanol dependence and liver injury in rats and baboons. Fed. Proc. 35(5):1232–1236.

    Google Scholar 

  • Lieber, C. S., and DeCarli, L. M. (1982). The feeding of alcohol in liquid diets: Two decades of applications and 1982 update. Alcohol Clin. Exp. Res. 6:523–531.

    Article  CAS  PubMed  Google Scholar 

  • Lieber, C. S., and DeCarli, L. M. (1986). The feeding of ethanol in liquid diets: 1986 update. Alcohol Clin. Exp. Res. 10:550–553.

    Article  CAS  PubMed  Google Scholar 

  • Lieber, C. S., and Leo, M.A. (1992). Alcohol and the liver. Chapter 7. In: Lieber, C.S. (ed.). Medical and Nutritional Complications of Alcoholism: Mechanisms and Management. Plenum Medical Book Co., New York, pp. 185–239.

    Google Scholar 

  • Lieber, C. S., Jones, D. P., Mendelson, J., and DeCarli, L. M. (1963). Fatty liver, hyperlipemia and hyperuricemia produced by prolonged alcohol consumption, despite adequate dietary intake. Trans. Assoc. Am. Physicians LXXVI:289–301.

    Google Scholar 

  • Lieber, C. S., Jones, D. P., and DeCarli, L. M. (1965). Effects of prolonged ethanol intake: Production of fatty liver despite adequate diets. J. Clin. Invest. 44:1009–1021.

    Article  CAS  PubMed  Google Scholar 

  • Lieber, C. S., DeCarli, L. M., Gang, H., Walker, G., and Rubin, E. (1972). Hepatic effects of long-term ethanol consumption in primates. In: Goldsmith, E. I., and Moor Jankowski, J. (eds.). Medical Primatology, Part 3. S. Karger, Basel, pp. 270–278.

    Google Scholar 

  • Lieber, C. S., DeCarli, L. M., and Rubin, E. (1975). Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets. Proc. Natl. Acad. Sci. U.S.A. 72:437–441.

    Google Scholar 

  • Lieber, C. S., Leo, M. A., Mak, K. M., DeCarli, L. M., and Sato, S. (1985). Choline fails to prevent liver fibrosis in ethanol-fed baboons but causes toxicity. Hepatology 5:561–572.

    Article  CAS  PubMed  Google Scholar 

  • Lieber, C. S., Baraona, E., Hernandez-Munoz, R., Kubota, S., Sato, N., Kawano, S., Matsumura, T., and Inatomi, N. (1989). Impaired oxygen utilization. A new mechanism for the hepatotoxicity of ethanol in sub-human primates. J. Clin. Invest. 83:1682–1690.

    Article  CAS  PubMed  Google Scholar 

  • Lieber, C. S., DeCarli, L. M., Mak, K. M., Kim, C. I., and Leo, M. A. (1990a). Attenuation of alcohol-induced hepatic fibrosis by polyunsaturated lecithin. Hepatology 12:1390–1398.

    Google Scholar 

  • Lieber, C. S., Casini, A., DeCarli, L. M., Kim, C. I., Lowe, N., Sasaki, R., and Leo, M. A. (1990b). S-adenosyl-l-methionine attenuates alcohol-induced liver injury in the baboon. Hepatology 11:165–172.

    Google Scholar 

  • Lieber, C. S., Robins, S. J., Li, J., DeCarli, L. M., Mak, K. M., Fasulo, J. M., and Leo, M. A. (1994a). Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology 106:152–159.

    Google Scholar 

  • Lieber, C. S., Robins, S. J., and Leo, M. A. (1994b). Hepatic phosphatidylethanolamine methytransferase activity is decreased by ethanol and increased by phosphatidylcholine. Alcohol Clin. Exp. Res. 18:592–595.

    Google Scholar 

  • Lieber, C. S., Leo, M. A., Aleynik, S. I., Aleynik, M. K., and DeCarli, L. M. (1997). Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon. Alcohol Clin. Exp. Res. 21:375–379.

    CAS  PubMed  Google Scholar 

  • Lieber, C. S., Leo, M. A., Cao, Q., Ren, C., and DeCarli, L. M. (2003). Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons. J. Clin. Gastroenterol. 37: 336–339.

    Article  CAS  PubMed  Google Scholar 

  • Mak, K. M., and Lieber, C. S. (1984). Alterations in endothelial fenestrations in liver sinusoids of baboons fed alcohol: A scanning electron microscopic study. Hepatology 4:386–391.

    Article  CAS  PubMed  Google Scholar 

  • Mak, K. M., Leo, M. A., and Lieber, C. S. (1984). Alcoholic liver injury in baboons: Transformation of lipocytes to transitional cells. Gastroenterology 87:188–200.

    CAS  PubMed  Google Scholar 

  • Mato, J. M., Cámara, J., Fernández de Paz, J., Caballería, L., Coll, S., Caballero, A., García-Buey, L., Beltrán, J., Benita, V., Caballería, J., Solá, R., Moreno-Otero, R., Barrao, F., Martin-Duce, A., Correa, J. A., Parès, A., Barro, E., García-Magaz, I., Puerta, J. L., Moreno, J., Boissard, G., Ortiz, P., and Rodès, J. (1999). S-adenosylmethionine in alcoholic liver cirrhosis: A randomized, placebo-controlled, double-blind, multicentre clinical trial. J. Hepatol. 30:1081–1089.

    Article  CAS  PubMed  Google Scholar 

  • Pares, A., Planas, R., Torres, M., Caballeria, J., Viver, J. M., Acero, D., Panes, J., Rigau, J., Santos, J., and Rodes, J. (1998). Effects of silymarin in alcoholic patients with cirrhosis of the liver: Results of a controlled, double-blind, randomized and multicenter trial. J. Hepatol. 28: 615–621.

    Article  CAS  PubMed  Google Scholar 

  • Popper, H., and Lieber, C. S. (1980). Histogenesis of alcoholic fibrosis and cirrhosis in the baboon. Am. J. Pathol. 98:695–716.

    CAS  PubMed  Google Scholar 

  • Portman, O. W. (1970). Nutritional requirements (NRC) of nonhuman primates. In: Harris R. S. (ed.), Feeding and Nutrition of Nonhuman Primates. Academic Press, New York, pp. 87–115.

    Google Scholar 

  • Shaw, S., Jayatilleke, E., Ross, W. A., Gordon, E. R., and Lieber, C. S. (1981). Ethanol-induced lipid peroxidation: Potentiation by long-term alcohol feeding and attenuation by methionine. Effect of different subtrates. J. Lab. Clin. Med. 98:417–425.

    CAS  PubMed  Google Scholar 

  • Sundler, R., and Akesson, B. (1975). Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different substrates. J. Biol. Chem. 250:3359–3367.

    CAS  PubMed  Google Scholar 

  • van Waes, L., and Lieber, C. S. (1977). Early perivenular sclerosis in alcoholic fatty liver: An index of progressive liver injury. Gastroenterology 73:646–650.

    PubMed  Google Scholar 

  • Vendemiale, G., Altomare, E., Trizio, T., Le Grazie, C., Di Padova, C., Salerno, M. T., Carrieri, V., and Albano, O. (1989). Effect of oral S-adenosyl-l-methionine on hepatic glutathione in patients with liver disease. Scand. J. Gastroenterol. 24:407–415.

    Article  CAS  PubMed  Google Scholar 

  • Worner, T. M., and Lieber, C. S. (1985). Perivenular fibrosis as precursor lesion of cirrhosis. JAMA 254:627–630.

    Article  CAS  PubMed  Google Scholar 

  • Yamada, S., Mak, K. M., and Lieber, C. S. (1985). Chronic ethanol consumption alters rat liver plasma membranes and potentiates release of alkaline phosphatase. Gastroenterology 88: 1799–1806.

    CAS  PubMed  Google Scholar 

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Lieber, C.S., Leo, M.A., DeCarli, L.M. (2009). Baboon Model for Alcoholic Liver Disease: 1973–2003. In: VandeBerg, J.L., Williams-Blangero, S., Tardif, S.D. (eds) The Baboon in Biomedical Research. Developments in Primatology: Progress and Prospects. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75991-3_15

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