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Immune-Mediated Diseases pp 213–223Cite as

Myeloid-Derived Suppressor Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 601))

Abstract

The development of tumor-specific T cell tolerance is largely responsible for tumor escape. Accumulation of myeloid-derived suppressor cells (MDSCs) in animal tumor models as well as in cancer patients is involved in tumor-associated T cell tolerance. In recent years, it has become increasingly evident that MDSCs bring about antigen-specific T cell tolerance by various mechanisms, which is the focus of this chapter.

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Authors and Affiliations

  1. H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA

    Srinivas Nagaraj & Dmitry I. Gabrilovich

Authors
  1. Srinivas Nagaraj
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  2. Dmitry I. Gabrilovich
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Correspondence to Dmitry I. Gabrilovich .

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Editors and Affiliations

  1. Division of Clinical Immunopathology, 5725 Children’s Hospital of Pittsburgh, Main Tower, 200 Lothrop Street, Pittsburgh, PA, 15213, USA

    Michael R. Shurin (Associate Professor of Pathology and Immunology, Associate Director) (Associate Professor of Pathology and Immunology, Associate Director)

  2. Institute for Continuing Medical Education, Russian Association of Pediatric Allergology and Immunology, Clinical and Research Center of Allergy and Immunology, Ostrovitianova St., Bldg. 6, Moscow, 117513, Russia

    Yuri S. Smolkin (Professor of Immunology, Vise-President, Director) (Professor of Immunology, Vise-President, Director)

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Nagaraj, S., Gabrilovich, D.I. (2007). Myeloid-Derived Suppressor Cells. In: Shurin, M.R., Smolkin, Y.S. (eds) Immune-Mediated Diseases. Advances in Experimental Medicine and Biology, vol 601. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72005-0_22

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