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Pediatric Otitis Media with Effusion

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Evidence-Based Otolaryngology

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Abstract

A computerized Ovid search of MEDLINE 1966–January 2004 was performed. The terms “otitis media” and “antibiotics” were exploded and the resulting articles were cross-referenced, yielding 1947 trials. Given the known richness of the otitis media literature and the authority of higher levels of evidence, these articles were then limited to randomized controlled trials (RCTs), resulting in 302 articles. These articles were then reviewed to identify those that met the following inclusion criteria: 1) patient population <18 years of age with documented otitis media with effusion (OME), 2) intervention with amoxicillin therapy alone versus placebo control, 3) outcome measured in terms of presence or absence of middle ear effusion (MEE) with a statistical analysis. Articles comparing intervention with amoxicillin/clavulanate, cephalosporins, trimethoprim-sulfamethoxazole, and erythromycin with placebo were excluded here but are presented separately in this chapter. The bibliographies of articles that met these inclusion criteria were manually examined to determine if any further relevant articles could be identified.

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References

  1. Podoshin L, Fradis M, Ben-David Y, Faraggi D. The efficacy of oral steroids in the treatment of persistent otitis media with effusion. [see comment.] Arch Otolaryngol Head Neck Surg, 1990;16(12):1404–1406.

    Google Scholar 

  2. Mandel EM, Rockette HE, Bluestone CD, Paradise JL, Nozza RJ. Efficacy of amoxicillin with and without decongestantantihistamine for otitis media with effusion in children. Results of a double-blind, randomized trial. N Engl J Med, 1987;316(8):432–437.

    Article  CAS  PubMed  Google Scholar 

  3. Mandel EM, Rockette HE, Paradise JL, Bluestone CD, Nozza RJ. Comparative efficacy of erythromycin-sulfisoxazole, cefaclor, amoxicillin or placebo for otitis media with effusion in children. Pediatr Infect Dis J, 1991;10(12):899–906.

    CAS  PubMed  Google Scholar 

  4. Mandel EM, Casselbrant ML, Rockette HE, Bluestone CD, Kurs-Lasky M. Efficacy of antimicrobial prophylaxis for recurrent middle ear effusion. Pediatr Infect Dis J 1996; 15(12):1074–1082.

    Article  CAS  PubMed  Google Scholar 

References

  1. Thomsen J, Sederberg-Olsen J, Balle V, Vejlsgaard R, Stangerup SE, Bondesson G. Antibiotic treatment of children with secretory otitis media. A randomized, double-blind, placebo-controlled study. [see comment]. Arch Otolaryngol Head Neck Surg 1989;115(4):447–451.

    CAS  PubMed  Google Scholar 

  2. van Balen FA, de Melker RA, Touw-Otten FW. Double-blind randomised trial of co-amoxiclav versus placebo for persistent otitis media with effusion in general practice. [see comment]. Lancet, 1996;348(9029):713–716.

    Article  PubMed  Google Scholar 

References

  1. Donaldson JD, Martin GF, Maltby CC, Seyward EB. The efficacy of pulse-dosed antibiotic therapy in the management of otitis media with effusion. J Otolaryngol 1990; 19(3):175–178.

    CAS  PubMed  Google Scholar 

  2. Mandel EM, Rockette HE, Paradise JL, Bluestone CD, Nozza RJ. Comparative efficacy of erythromycin-sulfisoxazole, cefaclor, amoxicillin or placebo for otitis media with effusion in children. Pediatric Infect Dis J 1991;10(12):899–906.

    CAS  Google Scholar 

  3. Hemlin C, Carenfelt C, Papatziamos G. Single dose of beta-methasone in combined medical treatment of secretory otitis media. Ann Otol Rhinol Laryngol 1997;106(5):359–363.

    CAS  PubMed  Google Scholar 

  4. Ernstson S, Anari M. Cefaclor in the treatment of otitis media with effusion. Acta Otolaryngol Suppl 1985;424:17–21.

    Article  CAS  PubMed  Google Scholar 

References

  1. Moller P, Dingsor G. Otitis media with effusion: can erythromycin reduce the need for ventilating tubes? J Laryngol Otol 1990;104:200–202.

    CAS  PubMed  Google Scholar 

  2. Mandel EM, Rockette HE, Paradise JL, Bluestone CD, Nozza RJ. Comparative efficacy of erythromycin-sulfisoxazole, cefaclor, amoxicillin or placebo for otitis media with effusion in children. Pediatr Infect Dis J 1991;10(12):899–906.

    Article  CAS  PubMed  Google Scholar 

  3. Schloss MD, Dempsey EE, Rishikof E, Sorger S, Grace M. Double blind study comparing erythromycin-sulfizoxazole to placebo in chronic otitis media with effusion. In Proc 4th Int Symp Recent Adv Otitis Media. New York: BC Decker, 1987.

    Google Scholar 

  4. Corwin MJ, Wiener LB, Daniels D, Efficacy of oral antibiotics for the treatment of persistent otitis media with effusion. International J Pediatr Otorhinolaryngol 1986;11(2):109–112.

    Article  CAS  Google Scholar 

References

  1. Marks NJ, Mills RP, Shaheen OH. A controlled trial of cotrimoxazole therapy in serous otitis media. J Laryngol Otol 1981;95(10):1003–1009.

    Article  CAS  PubMed  Google Scholar 

  2. Daly K, Giebink GS, Batalden PB, Anderson RS, Lindgren B. Resolution of otitis media with effusion with the use of a stepped treatment regimen of trimoprim sulfamethoxazole and prednisone. Pediatr Infect Dis J 1991;10(7):500–506.

    Article  CAS  PubMed  Google Scholar 

  3. Healy GB. Antimicrobial therapy of chronic otitis media with effusion. International J Pediatr Otorhinolaryngol 1984; 8(1):13–17.

    Article  CAS  Google Scholar 

  4. Schwartz RH, Rodriguez WJ. Trimethoprim sulfamethoxizole treatment of persistent otitis media with effusion. Pediatr Infect Dis J 1982;1(5):333–335.

    Article  CAS  Google Scholar 

  5. Giebink GS, Batalden PB, Le CT, Lassman FM, Buran DJ, Seltz AE. A controlled trial comparing three treatments for chronic otitis media with effusion. Pediatr Infect Dis J 1990; 9(1):33–40.

    Article  CAS  PubMed  Google Scholar 

References

  1. Richards M, Giannoni C. Quality-of-life outcomes after surgical intervention for otitis media. Arch Otolaryngol Head Neck Surg 2002;128(7):776–782.

    PubMed  Google Scholar 

  2. Rosenfeld RM, Bhaya MH, Bower CM, et al. Imopact of tympanostomy tubes on child quality of life. Arch Otolaryngol Head Neck Surg 2000;126(5):585–592.

    CAS  PubMed  Google Scholar 

  3. Rovers MM, Krabbe PF, Straatman H, Ingels K, van der Wilt GJ, Zielhuis GA. Randomised controlled trial of the effect of ventilation tubes (grommets) on quality of life at age 1–2 years [see comment]. Arch Dis Child 2001;84(1):45–49.

    Article  CAS  PubMed  Google Scholar 

  4. Timmerman AA, Anteunis LJ, Meesters CM. Responseshift bias and parent-reported quality of life in children with otitis media. Arch Otolaryngol Head Neck Surg 2003;129(9):987–991.

    Article  PubMed  Google Scholar 

  5. Campbell DT, Fiske DW. Convergent and discriminant validation by the multitrait-multimethod matrix. Psychol Bull 1959;56:81–105.

    Article  CAS  PubMed  Google Scholar 

  6. Trochim WM. Research Methods Knowledge Base. Cornell University; 2000.

    Google Scholar 

References

  1. Maw AR. Chronic otitis media with effusion and adenotonsillectomy—a prospective randomized controlled study. Int J Peditra Otorhinolaryngol 1983;6(3):239–246.

    CAS  Google Scholar 

  2. Maw AR. Chronic otitis media with effusion (glue ear) and adenotonsillectomy: prospective randomised controlled study. Br Med J (Clin Res Ed) 1983;287(6405):1586–1588.

    Article  CAS  Google Scholar 

  3. Maw AR. Factors affecting adenoidectomy for otitis media with effusion (glue ear). J R Soc Med 1985;78(12):1014–1018.

    CAS  PubMed  Google Scholar 

  4. Maw AR. Age and adenoid size in relation to adenoidectomy in otitis media with effusion. Am J Otolaryngol 1985; 6(3):245–248.

    Article  CAS  PubMed  Google Scholar 

  5. Maw AR. The long-term effect of adenoidectomy on established otitis media with effusion in children. Auris Nasus Larynx 1985;12(Suppl 1):S234–236.

    Google Scholar 

  6. Maw AR, Parker A. Surgery of the tonsils and adenoids in relation to secretory otitis media in children. Acta Otolaryngol Suppl 1988;454:202–207.

    Article  CAS  PubMed  Google Scholar 

  7. Maw AR, Bawden R, O’Keefe L, Gurr P. Does the type of middle ear aspirate have any prognostic significance in otitis media with effusion in children? Clin Otolaryngol Allied Sci 1993;18(5):396–399.

    Article  CAS  PubMed  Google Scholar 

  8. Maw AR, Bawden R. The long-term outcome of secretory otitis media in children and the effects of surgical treatment: a ten year study. Acta Otorhinolaryngol Belg 1994;48(4):317–324.

    CAS  PubMed  Google Scholar 

  9. Bulman CH, Brook SJ, Berry MG. A prospective randomized trial of adenoidectomy vs grommet insertion in the treatment of glue ear. Clin Otolaryngol Allied Sci 1984;9(2):67–75.

    Article  CAS  PubMed  Google Scholar 

References

  1. Maw AR, Bawden R, O’Keefe L, Gurr P. Does the type of middle ear aspirate have any prognostic significance in otitis media with effusion in children? Clin Otolaryngol Allied Sci 1993;18(5):396–399.

    Article  CAS  PubMed  Google Scholar 

  2. Bulman CH, Brook SJ, Berry MG. A prospective randomized trial of adenoidectomy vs grommet insertion in the treatment of glue ear. Clin Otolaryngol Allied Sci 1984;9(2);67–75.

    Article  CAS  PubMed  Google Scholar 

References

  1. Gates GA, Avery CA, Prihoda TJ, Cooper JC Jr. Effectiveness of adenoidectomy and tympanostomy tubes in the treatment of chronic otitis media with effusion. N Engl J Med 1987;317(23):1444–1451.

    Article  CAS  PubMed  Google Scholar 

  2. Gates GA, Avery CA, Cooper JC Jr, Prihoda TJ. Chronic secretory otitis media: effects of surgical management. Ann Otol Rhinol Laryngol Suppl 1989;138:2–32.

    CAS  PubMed  Google Scholar 

  3. Maw AR, Bawden R, O’Keefe L, Gurr P. Does the type of middle ear aspirate have any prognostic significance in otitis media with effusion in children? Clin Otolaryngol Allied Sci 1993;18(5):396–399.

    Article  CAS  PubMed  Google Scholar 

  4. Black N, Crowther J, Freeland A. The effectiveness of adenoidectomy in the treatment of glue ear: a randomized controlled trial. Clin Otolaryngol Allied Sci 1986;11(3):149–155

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Harvard Program in Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, MA, USA

    Jennifer J. Shin MD

  2. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA

    Michael J. Cunningham MD (Associate Professor) & Christopher J. Hartnick MD (Assistant Professor)

  3. Harvard Medical School, Boston, MA, USA

    Grace Chan MD

  4. Department of Otolaryngology and Communication Disorders, The Children’s Hospital, Boston, MA, USA

    Margaret Kenna MD, MPH (Associate Professor)

Authors
  1. Jennifer J. Shin MD
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  2. Michael J. Cunningham MD
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  3. Christopher J. Hartnick MD
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  4. Grace Chan MD
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  5. Margaret Kenna MD, MPH
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Editor information

Editors and Affiliations

  1. Harvard Program in Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Jennifer J. Shin MD

  2. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Christopher J. Hartnick MD, MSE

  3. Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Gregory W. Randolph MD (Pediatric Otolaryngology) (Pediatric Otolaryngology)

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Shin, J.J., Cunningham, M.J., Hartnick, C.J., Chan, G., Kenna, M. (2008). Pediatric Otitis Media with Effusion. In: Shin, J.J., et al. Evidence-Based Otolaryngology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49979-6_7

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  • DOI: https://doi.org/10.1007/978-0-387-49979-6_7

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-24447-1

  • Online ISBN: 978-0-387-49979-6

  • eBook Packages: MedicineMedicine (R0)

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