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Laryngeal Squamous Cell Carcinoma: Advanced Disease

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Evidence-Based Otolaryngology

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Abstract

A computerized Ovid search of MEDLINE from 1966 to May 2004 was performed. The subject headings “laryngectomy” and “quality of life” were exploded and the resulting articles were cross-referenced, yielding 122 publications. These articles were then reviewed to identify those that met the following inclusion criteria: 1) patient population with primary laryngeal carcinoma, 2) intervention with open partial laryngectomy versus total laryngectomy, 3) outcome measured in terms of validated instruments measuring disease-specific quality of life (QOL). (Global QOL is addressed in the subsequent section, 31.A.ii.) Articles in which data from patients with laryngeal carciNoma were pooled with data from patients with oropharyngeal carcinoma were excluded. The one paper in which only two patients with hypopharyngeal carcinoma were pooled with 29 patients with purely laryngeal carcinoma was included. Articles in which results for either total laryngectomy alone or partial laryngectomy alone were reported, without comparative/controlled data, were also excluded. Reports using instruments that had Not been validated (i.e., untested questionnaires) were excluded.

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Author information

Authors and Affiliations

  1. Voice Center, Massachusetts Eye and Ear Infirmary, Boston, MA, USA

    Ramon Franco MD (Assistant Professor Otology and Laryngology, Harvard Medical School Director)

  2. Harvard Program in Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, MA, USA

    Jennifer J. Shin MD

  3. Vanderbilt University Medical Center, Nashville, TN, USA

    James Netterville MD (Professor of Otolaryngology, Associate Director of the Bill Wilkerson Center For Otolaryngology and Communication Sciences)

Authors
  1. Ramon Franco MD
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  2. Jennifer J. Shin MD
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  3. James Netterville MD
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  4. Babar Sultan
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  5. Lori Wirth
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  6. Merrill S. Kies
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Editor information

Editors and Affiliations

  1. Harvard Program in Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Jennifer J. Shin MD

  2. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Christopher J. Hartnick MD, MSE

  3. Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Gregory W. Randolph MD (Pediatric Otolaryngology) (Pediatric Otolaryngology)

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Franco, R., Shin, J.J., Netterville, J., Sultan, B., Wirth, L., Kies, M.S. (2008). Laryngeal Squamous Cell Carcinoma: Advanced Disease. In: Shin, J.J., et al. Evidence-Based Otolaryngology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49979-6_31

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  • DOI: https://doi.org/10.1007/978-0-387-49979-6_31

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-24447-1

  • Online ISBN: 978-0-387-49979-6

  • eBook Packages: MedicineMedicine (R0)

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