Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Laryngeal Squamous Cell Carcinoma: Early-Stage Disease

  • Chapter
Evidence-Based Otolaryngology

  • 2181 Accesses

Abstract

A computerized PubMed search of MEDLINE from 1966 to 2005 was performed. The diagnosis terms “larynx,” “glottic,” or “true vocal cord” were exploded and combined. The terms “cancer,” “carcinoma,” or “squamous cell carcinoma” were exploded and combined. The above two searches were then limited to “early stage,” “T1,” “T2,” “stage I,” or stage II to yield articles focused on early-stage I–II glottic cancer. These articles were then subjected to the PubMed Clinical Queries using Research Methodology Filters [1] optimized for sensitive/broad search for articles in the category of “therapy,” yielding 311 articles. These articles were then cross-referenced with the headings “radiation,” “radiotherapy,” “laser excision,” “endoscopic surgery,” “endolaryngeal resection,” “transoral surgery,” “CO2 cordectomy,” “laser cordectomy,” or “microsurgery,” yielding a total of 250 publications, whose titles and abstracts were reviewed to identify those that met the following inclusion criteria: 1) patient population with primary newly diagnosed, biopsyproven T1 or T2 larynx carcinoma, 2) intervention with radiation or endoscopic resection (with or without laser), 3) outcome measured in terms of survival, local recurrence, and/or larynx preservation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Haynes RB, et al. Optimal search strategies for retrieving scientifically strong studies of treatment from Medline: analytical survey. BMJ 2005;330(7501)1179.

    Article  PubMed  Google Scholar 

  2. Ansarin M, et al. Endoscopic CO2 laser surgery for early glottic cancer in patients who are candidates for radiotherapy: results of a prospective nonrandomized study. Head Neck 2006;28(2):121–125.

    Article  PubMed  Google Scholar 

  3. Brandenburg JH. Laser cordotomy versus radiotherapy: an objective cost analysis. Ann Otol Rhinol Laryngol 2001;110(4):312–318.

    PubMed  CAS  Google Scholar 

  4. Cellai E, et al. Radical radiotherapy for early glottic cancer: results in a series of 1087 patients from two Italian radiation oncology centers. I. The case of T1N0 disease. Int J Radiat Oncol Biol Phys 2005;63(5):1378–1386.

    Article  PubMed  Google Scholar 

  5. Csanady M, Czigner J, Savay L. Endolaryngeal CO2 laser microsurgery of early vocal cord cancer. A retrospective study. Adv Otorhinolaryngol 1995;49:219–221.

    PubMed  CAS  Google Scholar 

  6. Dey P, et al. Radiotherapy versus open surgery versus endolaryngeal surgery (with or without laser) for early laryngeal squamous cell cancer. Cochrane Database Syst Rev 2002(2):CD002027.

    PubMed  Google Scholar 

  7. Eckel HE. Local recurrences following transoral laser surgery for early glottic carcinoma: frequency, management, and outcome. Ann Otol Rhinol Laryngol 2001; 110(1):7–15.

    PubMed  CAS  Google Scholar 

  8. Fein DA, et al. T1-T2 squamous cell carcinoma of the glottic larynx treated with radiotherapy: a multivariate analysis of variables potentially influencing local control. Int J Radiat Oncol Biol Phys 1993;25(4):605–611.

    PubMed  CAS  Google Scholar 

  9. Franchin G, et al. Radiotherapy for patients with early-stage glottic carcinoma: univariate and multivariate analyses in a group of consecutive, unselected patients. Cancer 2003;98(4):765–772.

    Article  PubMed  Google Scholar 

  10. Frata P, et al. Radical radiotherapy for early glottic cancer: results in a series of 1087 patients from two Italian radiation oncology centers. II. The case of T2N0 disease. Int J Radiat Oncol Biol Phys 2005;63(5):1387–1394.

    Article  PubMed  Google Scholar 

  11. Gallo A, et al. CO2 laser cordectomy for early-stage glottic carcinoma: a long-term follow-up of 156 cases. Laryngoscope 2002;112(2):370–374.

    Article  PubMed  Google Scholar 

  12. Garden AS, et al. Results of radiotherapy for T2N0 glottic carcinoma: does the “2” stand for twice-daily treatment? Int J Radiat Oncol Biol Phys 2003;55(2):322–328.

    PubMed  Google Scholar 

  13. Hirano M, Hirade Y, Kawasaki H. Vocal function following carbon dioxide laser surgery for glottic carcinoma. Ann Otol Rhinol Laryngol 1985;94(3):232–235.

    PubMed  CAS  Google Scholar 

  14. Keilmann A, et al. Vocal function following laser and conventional surgery of small malignant vocal fold tumours. J Laryngol Otol 1996;110(12):1138–1141.

    Article  PubMed  CAS  Google Scholar 

  15. Krespi YP, Meltzer CJ. Laser surgery for vocal cord carcinoma involving the anterior commissure. Ann Otol Rhinol Laryngol 1989;98(2):105–109.

    PubMed  CAS  Google Scholar 

  16. Maurizi M, et al. Laser carbon dioxide cordectomy versus open surgery in the treatment of glottic carcinoma: our results. Otolaryngol Head Neck Surg 2005;132(6):857–861.

    Article  PubMed  Google Scholar 

  17. McGuirt WF, et al. Comparative voice results after laser resection or irradiation of T1 vocal cord carcinoma. Arch Otolaryngol Head Neck Surg 1994;120(9):951–955.

    PubMed  CAS  Google Scholar 

  18. Medini E, et al. Radiation therapy in early carcinoma of the glottic larynx T1N0M0. Int J Radiat Oncol Biol Phys 1996;36(5):1211–1213.

    PubMed  CAS  Google Scholar 

  19. Mendenhall WM, et al. T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol 2001;19(20):4029–4036.

    PubMed  CAS  Google Scholar 

  20. Motta G, et al. T1-T2-T3 glottic tumors: fifteen years experience with CO2 laser. Acta Otolaryngol Suppl 1997:527: 155–159.

    Article  PubMed  CAS  Google Scholar 

  21. Ossoff RH, Sisson GA, Shapshay SM. Endoscopic management of selected early vocal cord carcinoma. Ann Otol Rhinol Laryngol 1985;94(6 Pt 1):560–564.

    PubMed  CAS  Google Scholar 

  22. Peretti G, et al. Endoscopic CO2 laser excision for tis, T1, and T2 glottic carcinomas: cure rate and prognostic factors. Otolaryngol Head Neck Surg 2000;123(1 Pt 1):124–131.

    Article  PubMed  CAS  Google Scholar 

  23. Pradhan SA, et al. Transoral laser surgery for early glottic cancers. Arch Otolaryngol Head Neck Surg 2003;129(6):623–625.

    Article  PubMed  Google Scholar 

  24. Rebeic EE, et al. Preliminary clinical results of window partial laryngectomy: a combined endoscopic and open technique. Ann Otol Rhinol Laryngol 2000;109(2):123–127.

    Google Scholar 

  25. Sigston E, et al. Early-stage glottic cancer: oncological results and margins in laser cordectomy. Arch Otolaryngol Head Neck Surg 2006;132(2):147–152.

    Article  PubMed  Google Scholar 

  26. Smith JC, Johnson JT, Myers EN. Management and outcome of early glottic carcinoma. Otolaryngol Head Neck Surg 2002;126(4):356–364.

    Article  PubMed  Google Scholar 

  27. Steiner W. Results of curative laser microsurgery of laryngeal carcinomas. Am J Otolaryngol 1993;14(2):116–121.

    Article  PubMed  CAS  Google Scholar 

  28. Wolfensberger M, Dort JC. Endoscopic laser surgery for early glottic carcinoma: a clinical and experimental study. Laryngoscope 1990;100(10 Pt 1):1100–1105.

    Article  PubMed  CAS  Google Scholar 

  29. Zeitels SM. Phonomicrosurgical treatment of early glottic cancer and carcinoma in situ. Am J Surg 1996;172(6):704–709.

    Article  PubMed  CAS  Google Scholar 

  30. Akine Y, et al. Radiotherapy of T1 glottic cancer with 6 MeVX rays. Int J Radiat Oncol Biol Phys 1991;20(6):1215–1218.

    PubMed  CAS  Google Scholar 

  31. Barton MB, et al. The effect of treatment time and treatment interruption on tumour control following radical radiotherapy of laryngeal cancer. Radiother Oncol 1992; 23(3):137–143.

    Article  PubMed  CAS  Google Scholar 

  32. Harwood AR, et al. Radiotherapy of early glottic cancer— I. Int J Radiat Oncol Biol Phys 1979;5(4):473–476.

    PubMed  CAS  Google Scholar 

  33. Harwood AR, Tierie A. Radiotherapy of early glottic cancer—II. Int J Radiat Oncol Biol Phys 1979;5(4):477–482.

    PubMed  CAS  Google Scholar 

  34. Hendrickson FR. Radiation therapy treatment of larynx cancers. Cancer 1985;55(9 Suppl):2058–2061.

    Article  PubMed  CAS  Google Scholar 

  35. Howell-Burke D, et al. T2 glottic cancer. Recurrence, salvage, and survival after definitive radiotherapy. Arch Otolaryngol Head Neck Surg 1990;116(7):830–835.

    PubMed  CAS  Google Scholar 

  36. Jones AS, et al. The treatment of early laryngeal cancers (T1-T2 N0): surgery or irradiation? Head Neck 2004; 26(2):127–135.

    Article  PubMed  Google Scholar 

  37. Karim AB, et al. Heterogeneity of stage II glottic carcinoma and its therapeutic implications. Int J Radiat Oncol Biol Phys 1987;13(3):313–317.

    PubMed  CAS  Google Scholar 

  38. Kelly MD, et al. Definitive radiotherapy in the management of stage I and II carcinomas of the glottis. Ann Otol Rhinol Laryngol 1989;98(3):235–239.

    PubMed  CAS  Google Scholar 

  39. Klintenberg C, et al. Primary radiotherapy of T1 and T2 glottic carcinoma—analysis of treatment results and prognostic factors in 223 patients. Acta Oncol 1996; 35(Suppl 8):81–86.

    Article  PubMed  Google Scholar 

  40. Le QT, et al. Influence of fraction size, total dose, and overall time on local control of T1-T2 glottic carcinoma. Int J Radiat Oncol Biol Phys 1997;39(1):115–126.

    PubMed  CAS  Google Scholar 

  41. Olszewski SJ, et al. The influence of field size, treatment modality, commissure involvement and histology in the treatment of early vocal cord cancer with irradiation. Int J Radiat Oncol Biol Phys 1985;11(7):1333–1337.

    PubMed  CAS  Google Scholar 

  42. Pellitteri PK, et al. Radiotherapy. The mainstay in the treatment of early glottic carcinoma. Arch Otolaryngol Head Neck Surg 1991;117(3):297–301.

    PubMed  CAS  Google Scholar 

  43. Schwaab G, et al. Surgical salvage treatment of T1/T2 glottic carcinoma after failure of radiotherapy. Am J Surg 1994;168(5):474–475.

    Article  PubMed  CAS  Google Scholar 

  44. Spector JG, et al. Stage I (T1 N0 M0) squamous cell carcinoma of the laryngeal glottis: therapeutic results and voice preservation. Head Neck 1999;21(8):707–717.

    Article  PubMed  CAS  Google Scholar 

  45. Van den Bogaert W, Ostyn F, van der Schueren E. The significance of extension and impaired mobility in cancer of the vocal cord. Int J Radiat Oncol Biol Phys 1983;9(2): 181–184.

    PubMed  Google Scholar 

  46. Wiggenraad RG, et al. The importance of vocal cord mobility in T2 laryngeal cancer. Radiother Oncol 1990;18(4): 321–327.

    Article  PubMed  CAS  Google Scholar 

  47. Yu E, et al. Impact of radiation therapy fraction size on local control of early glottic carcinoma. Int J Radiat Oncol Biol Phys 1997;37(3):587–591.

    PubMed  CAS  Google Scholar 

  48. Rosier JF, et al. Comparison of external radiotherapy, laser microsurgery and partial laryngectomy for the treatment of T1N0M0 glottic carcinomas: a retrospective evaluation. Radiother Oncol 1998;48(2):175–183.

    Article  PubMed  CAS  Google Scholar 

References

  1. Haynes RB, et al. Optimal search strategies for retrieving scientifically strong studies of treatment from Medline: analytical survey. BMJ 2005;330(7501):1179.

    Article  PubMed  Google Scholar 

  2. Akine Y, et al. Radiotherapy of T1 glottic cancer with 6 MeV X rays. Int J Radiat Oncol Biol Phys 1991;20(6): 1215–1218.

    PubMed  CAS  Google Scholar 

  3. Ansarin M, et al. Endoscopic CO2 laser surgery for early glottic cancer in patients who are candidates for radiotherapy: results of a prospective nonrandomized study. Head Neck 2006;28(2):121–125.

    Article  PubMed  Google Scholar 

  4. Barton MB, et al. The effect of treatment time and treatment interruption on tumour control following radical radiotherapy of laryngeal cancer. Radiother Oncol 1992; 23(3):137–143.

    Article  PubMed  CAS  Google Scholar 

  5. Brandenburg JH. Laser cordotomy versus radiotherapy: an objective cost analysis. Ann Otol Rhinol Laryngol 2001;110(4):312–318.

    PubMed  CAS  Google Scholar 

  6. Cellai E, et al. Radical radiotherapy for early glottic cancer: results in a series of 1087 patients from two Italian radiation oncology centers. I. The case of T1N0 disease. Int J Radiat Oncol Biol Phys 2005;63(5):1378–1386.

    Article  PubMed  Google Scholar 

  7. Csanady M, Czigner J, Savay L. Endolaryngeal CO2 laser microsurgery of early vocal cord cancer. A retrospective study. Adv Otorhinolaryngol 1995;49:219–221.

    PubMed  CAS  Google Scholar 

  8. Delsupehe KG, et al. Voice quality after narrow-margin laser cordectomy compared with laryngeal irradiation. Otolaryngol Head Neck Surg 1999;121(5):528–533.

    Article  PubMed  CAS  Google Scholar 

  9. Eckel HE. Local recurrences following transoral laser surgery for early glottic carcinoma: frequency, management, and outcome. Ann Otol Rhinol Laryngol 2001; 110(1):7–15.

    PubMed  CAS  Google Scholar 

  10. Fein DA, et al. T1-T2 squamous cell carcinoma of the glottic larynx treated with radiotherapy: a multivariate analysis of variables potentially influencing local control. Int J Radiat Oncol Biol Phys 1993;25(4):605–611.

    PubMed  CAS  Google Scholar 

  11. Franchin G, et al. Radiotherapy for patients with early-stage glottic carcinoma: univariate and multivariate analyses in a group of consecutive, unselected patients. Cancer 2003;98(4):765–772.

    Article  PubMed  Google Scholar 

  12. Frata P, et al. Radical radiotherapy for early glottic cancer: results in a series of 1087 patients from two Italian radiation oncology centers. II. The case of T2N0 disease. Int J Radiat Oncol Biol Phys 2005;63(5):1387–1394.

    Article  PubMed  Google Scholar 

  13. Gallo A, et al. CO2 laser cordectomy for early-stage glottic carcinoma: a long-term follow-up of 156 cases. Laryngoscope 2002;112(2):370–374.

    Article  PubMed  Google Scholar 

  14. Garden AS, et al. Results of radiotherapy for T2N0 glottic carcinoma: does the “2” stand for twice-daily treatment? Int J Radiat Oncol Biol Phys 2003;55(2):322–328.

    PubMed  Google Scholar 

  15. Harrison LB, et al. Prospective computer-assisted voice analysis for patients with early stage glottic cancer: a preliminary report of the functional result of laryngeal irradiation. Int J Radiat Oncol Biol Phys 1990;19(1):123–127.

    PubMed  CAS  Google Scholar 

  16. Harwood AR, et al. Radiotherapy of early glottic cancer— I. Int J Radiat Oncol Biol Phys 1979;5(4):473–476.

    PubMed  CAS  Google Scholar 

  17. Harwood AR, Tierie A. Radiotherapy of early glottic cancer—II. Int J Radiat Oncol Biol Phys 1979;5(4):477–482.

    PubMed  CAS  Google Scholar 

  18. Hendrickson FR. Radiation therapy treatment of larynx cancers. Cancer 1985;55(9 Suppl):2058–2061.

    Article  PubMed  CAS  Google Scholar 

  19. Hirano M, Hirade Y, Kawasaki H. Vocal function following carbon dioxide laser surgery for glottic carcinoma. Ann Otol Rhinol Laryngol 1985;94(3):232–235.

    PubMed  CAS  Google Scholar 

  20. Howell-Burke D, et al. T2 glottic cancer. Recurrence, salvage, and survival after definitive radiotherapy. Arch Otolaryngol Head Neck Surg 1990;116(7):830–835.

    PubMed  CAS  Google Scholar 

  21. Jones AS, et al. The treatment of early laryngeal cancers (T1-T2 N0): surgery or irradiation? Head Neck 2004;26(2): 127–135.

    Article  PubMed  Google Scholar 

  22. Karim AB, et al. Heterogeneity of stage II glottic carcinoma and its therapeutic implications. Int J Radiat Oncol Biol Phys 1987;13(3):313–317.

    PubMed  CAS  Google Scholar 

  23. Keilmann A, et al. Vocal function following laser and conventional surgery of small malignant vocal fold tumours. J Laryngol Otol 1996;110(12):1138–1141.

    Article  PubMed  CAS  Google Scholar 

  24. Kelly MD, et al. Definitive radiotherapy in the management of stage I and II carcinomas of the glottis. Ann Otol Rhinol Laryngol 1989;98(3):235–239.

    PubMed  CAS  Google Scholar 

  25. Klintenberg C, et al. Primary radiotherapy of T1 and T2 glottic carcinoma—analysis of treatment results and prognostic factors in 223 patients. Acta Oncol 1996;35(Suppl 8): 81–86.

    Article  PubMed  Google Scholar 

  26. Krespi YP, Meltzer CJ. Laser surgery for vocal cord carcinoma involving the anterior commissure. Ann Otol Rhinol Laryngol 1989;98(2):105–109.

    PubMed  CAS  Google Scholar 

  27. Le QT, et al. Influence of fraction size, total dose, and overall time on local control of T1-T2 glottic carcinoma. Int J Radiat Oncol Biol Phys 1997;39(1):115–126.

    PubMed  CAS  Google Scholar 

  28. Lustig RA, et al. The Patterns of Care Outcome Studies: results of the national practice in carcinoma of the larynx. Int J Radiat Oncol Biol Phys 1984;10(12):2357–2362.

    PubMed  CAS  Google Scholar 

  29. Maurizi M, et al. Laser carbon dioxide cordectomy versus open surgery in the treatment of glottic carcinoma: our results. Otolaryngol Head Neck Surg 2005;132(6):857–861.

    Article  PubMed  Google Scholar 

  30. McGuirt WF, et al. Comparative voice results after laser resection or irradiation of T1 vocal cord carcinoma. Arch Otolaryngol Head Neck Surg 1994;120(9):951–955.

    PubMed  CAS  Google Scholar 

  31. Medini E, et al. Radiation therapy in early carcinoma of the glottic larynx T1N0M0. Int J Radiat Oncol Biol Phys 1996;36(5):1211–1213.

    PubMed  CAS  Google Scholar 

  32. Mendenhall WM, et al. T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol 2001;19(20):4029–4036.

    PubMed  CAS  Google Scholar 

  33. Motta G, et al. T1-T2-T3 glottic tumors: fifteen years experience with CO2 laser. Acta Otolaryngol Suppl 1997;527: 155–159.

    Article  PubMed  CAS  Google Scholar 

  34. Olszewski SJ, et al. The influence of field size, treatment modality, commissure involvement and histology in the treatment of early vocal cord cancer with irradiation. Int J Radiat Oncol Biol Phys 1985;11(7):1333–1337.

    PubMed  CAS  Google Scholar 

  35. Ossoff RH, Sisson GA, Shapshay SM. Endoscopic management of selected early vocal cord carcinoma. Ann Otol Rhinol Laryngol 1985;94(6 Pt 1):560–564.

    PubMed  CAS  Google Scholar 

  36. Pellitteri PK, et al. Radiotherapy. The mainstay in the treatment of early glottic carcinoma. Arch Otolaryngol Head Neck Surg 1991;117(3):297–301.

    PubMed  CAS  Google Scholar 

  37. Peretti G, et al. Endoscopic CO2 laser excision for tis, T1, and T2 glottic carcinomas: cure rate and prognostic factors. Otolaryngol Head Neck Surg 2000;123(1 Pt 1): 124–131.

    Article  PubMed  CAS  Google Scholar 

  38. Pradhan SA, et al. Transoral laser surgery for early glottic cancers. Arch Otolaryngol Head Neck Surg 2003;129(6):623–625.

    Article  PubMed  Google Scholar 

  39. Rebeiz EE, et al. Preliminary clinical results of window partial laryngectomy: a combined endoscopic and open technique. Ann Otol Rhinol Laryngol 2000;109(2):123–127.

    PubMed  CAS  Google Scholar 

  40. Rosier JF, et al. Comparison of external radiotherapy, laser microsurgery and partial laryngectomy for the treatment of T1N0M0 glottic carcinomas: a retrospective evaluation. Radiother Oncol 1998;48(2):175–183.

    Article  PubMed  CAS  Google Scholar 

  41. Schwaab G, et al. Surgical salvage treatment of T1/T2 glottic carcinoma after failure of radiotherapy. Am J Surg 1994;168(5):474–475.

    Article  PubMed  CAS  Google Scholar 

  42. Sigston E, et al. Early-stage glottic cancer: oncological results and margins in laser cordectomy. Arch Otolaryngol Head Neck Surg 2006;132(2):147–152.

    Article  PubMed  Google Scholar 

  43. Smith JC, Johnson JT, Myers EN. Management and outcome of early glottic carcinomas. Otolaryngol Head Neck Surg 2002;126(4):356–364.

    Article  PubMed  Google Scholar 

  44. Spector JG, et al. Stage I (T1 N0 M0) squamous cell carcinoma of the laryngeal glottis: therapeutic results and voice preservation. Head Neck 1999;21(8):707–717.

    Article  PubMed  CAS  Google Scholar 

  45. Steiner W. Results of curative laser microsurgery of laryngeal carcinomas. Am J Otolaryngol 1993;14(2):116–121.

    Article  PubMed  CAS  Google Scholar 

  46. Van den Bogaert W, Ostyn F, van der Schueren E. The significance of extension and impaired mobility in cancer of the vocal cord. Int J Radiat Oncol Biol Phys 1983;9(2): 181–184.

    PubMed  Google Scholar 

  47. Verdonck-de Leeuw IM, et al. Mulditidimensional assessment of voice characteristics after radiotherapy for early glottic cancer. Laryngoscope 1999;109(2 Pt 1):241–248.

    Article  PubMed  CAS  Google Scholar 

  48. Verdonck-de Leeuw IM, et al. Consequences of voice impairment in daily life for patients following radiotherapy for early glottic cancer: voice quality, vocal function, and vocal performance. Int J Radiat Oncol Biol Phys 1999;44(5):1071–1078.

    PubMed  CAS  Google Scholar 

  49. Epstein BE, et al. Stage T1 glottic carcinoma: results of radiation therapy or laser excision. Radiology 1990;175(2): 567–570.

    PubMed  CAS  Google Scholar 

  50. Krengli M, et al. Voice quality after treatment for T1a glottic carcinoma—radiotherapy versus laser cordectomy. Acta Oncol 2004;43(3):284–289.

    Article  PubMed  Google Scholar 

  51. Rydell R, et al. Voice evaluation before and after laser excision vs. radiotherapy of T1A glottic carcinoma. Acta Otolaryngol 1995;115(4):560–565.

    Article  PubMed  CAS  Google Scholar 

  52. Tamura E, et al. Voice quality after laser surgery or radiotherapy for T1a glottic carcinoma. Laryngoscope 2003; 113(5):910–914.

    Article  PubMed  Google Scholar 

  53. Loughran S, et al. Quality of life and voice following endoscopic resection or radiotherapy for early glottic cancer. Clin Otolaryngol 2005;30(1):42–47.

    Article  PubMed  CAS  Google Scholar 

  54. Smith JC, et al. Quality of life, functional outcome, and costs of early glottic cancer. Laryngoscope 2003;113(1):68–76.

    Article  PubMed  Google Scholar 

  55. Stoeckli SJ, et al. Quality of life after treatment for early laryngeal carcinoma. Eur Arch Otorhinolaryngol 2001; 258(2):96–99.

    Article  PubMed  CAS  Google Scholar 

  56. Hassan SJ, Weymuller EA Jr. Assessment of quality of life in head and neck cancer patients. Head Neck 1993;15(6): 485–496.

    Article  PubMed  CAS  Google Scholar 

  57. Weymuller EA, et al. Quality of life in patients with head and neck cancer: lessons learned from 549 prospectively evaluated patients. Arch Otolaryngol Head Neck Surg 2000;126(3):329–335; discussion 335–336.

    PubMed  CAS  Google Scholar 

  58. List MA, et al. The Performance Status Scale for Head and Neck Cancer Patients and the Functional Assessment of Cancer Therapy-Head and Neck Scale. A study of utility and validity. Cancer 1996;77(11):2294–2301.

    Article  PubMed  CAS  Google Scholar 

  59. Bogaardt HC, et al. Validation of the Voice Handicap Index Using Rasch Analysis. J Voice 2006;Feb 24.

    Google Scholar 

  60. Deary IJ, et al. Short, self-report voice symptom scales: psychometric characteristics of the voice handicap index-10 and the vocal performance questionnaire. Otolaryngol Head Neck Surg 2004;131(3):232–235.

    Article  PubMed  Google Scholar 

  61. Hsiung MW, Pai L, Wang HW. Correlation between voice handicap index and voice laboratory measurements in dysphonic patients. Eur Arch Otorhinolaryngol 2002; 259(2):97–99.

    Article  PubMed  CAS  Google Scholar 

  62. Kandogan T, Sanal A. Quality of life, functional outcome, and voice handicap index in partial laryngectomy patients for early glottic cancer. BMC Ear Nose Throat Disord 2005;5(1):3.

    Article  PubMed  Google Scholar 

  63. Kandogan T, Sanal A. Quality of life, functional outcome, and voice handicap index in partial laryngectomy patients for early glottic cancer. BMC Ear Nose Throat Disord 2006;6:1.

    Article  Google Scholar 

  64. Portone CR, et al. Correlation of the Voice Handicap Index (VHI) and the Voice-Related Quality of Life Measure (V-RQOL). J Voice 2006.

    Google Scholar 

  65. Wilson JA, et al. The Voice Symptom Scale (VoiSS) and the Vocal Handicap Index (VHI): a comparison of structure and content. Clin Otolaryngol Allied Sci 2004;29(2):169–174.

    Article  PubMed  CAS  Google Scholar 

  66. Woisard V, et al. The Voice Handicap Index: correlation between subjective patient response and quantitative assessment of voice. J Voice 2006.

    Google Scholar 

  67. Carding PN, Horsley IA, Docherty GJ. The effectiveness of voice therapy for patients with non-organic dysphonia. Clin Otolaryngol Allied Sci 1998;23(4):310–318.

    Article  PubMed  CAS  Google Scholar 

  68. Deary IJ, et al. VoiSS: a patient-derived Voice Symptom Scale. J Psychosom Res 2003;54(5):483–489.

    Article  PubMed  Google Scholar 

  69. D’Antonio LL, et al. Quality of life and functional status measures in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 1996;122(5):482–487.

    PubMed  Google Scholar 

  70. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983;67(6):361–370.

    Article  PubMed  CAS  Google Scholar 

References

  1. de Campora E, Radici M, de Campora L. External versus endoscopic approach in the surgical treatment of glottic cancer. Eur Arch OtorhiN0laryngol 2001;258(10):533–536.

    Article  Google Scholar 

  2. Maurizi M, et al. Laser carbon dioxide cordectomy versus open surgery in the treatment of glottic carcinoma: our results. Otolaryngol Head Neck Surg 2005;132(6):857–861.

    Article  PubMed  Google Scholar 

  3. Puxeddu R, et al. Surgical therapy of T1 and selected cases of T2 glottic carcinoma: cordectomy, horizontal glottectomy and CO2 laser endoscopic resection. Tumori 2000; 86(4):277–282.

    PubMed  CAS  Google Scholar 

References

  1. Adamopoulos G, et al. Supraglottic laryngectomy—series report and analysis of results. J Laryngol Otol 1997;111(8): 730–734.

    Article  PubMed  CAS  Google Scholar 

  2. Akbas Y, Demireller A. Oncologic and functional results of supracricoid partial laryngectomy with cricohyoidopexy. Otolaryngol Head Neck Surg 2005;132(5):783–787.

    Article  PubMed  Google Scholar 

  3. Bataini JP, et al. Treatment of supraglottic cancer by radical high dose radiotherapy. Cancer 1974;33(5):1253–1262.

    Article  PubMed  CAS  Google Scholar 

  4. Biller HF, Lawson W. Partial laryngectomy for transglottic cancers. Ann Otol RhiN0l Laryngol 1984;93(4 Pt 1):297–300.

    CAS  Google Scholar 

  5. Bocca E. Limitations of supraglottic laryngectomy and conservative neck dissection. Can J Otolaryngol 1975;4(3): 403–419.

    PubMed  CAS  Google Scholar 

  6. Bocca E, Pignataro O, Oldini C. Supraglottic laryngectomy: 30 years of experience. Ann Otol RhiN0l Laryngol 1983;92(1 Pt 1):14–18.

    CAS  Google Scholar 

  7. Burstein FD, Calcaterra TC. Supraglottic laryngectomy: series report and analysis of results. Laryngoscope 1985; 95(7 Pt 1):833–836.

    PubMed  CAS  Google Scholar 

  8. Chevalier D, et al. Supraglottic hemilaryngopharyngectomy plus radiation for the treatment of early lateral margin and pyriform sinus carcinoma. Head Neck 1997;19(1):1–5.

    Article  PubMed  CAS  Google Scholar 

  9. Clippe S, et al. Role of brachytherapy in treatment of epidermoid carcinomas of the vallecula after conservative supraglottic laryngectomy followed by irradiation. Int J Radiat Oncol Biol Phys 2002;53(1):29–35.

    PubMed  Google Scholar 

  10. Deffebach RR, Phillips TL. Role of radiation therapy in the treatment of supraglottic carcinoma. Cancer 1972;30(5): 1159–1163.

    Article  PubMed  CAS  Google Scholar 

  11. DeSanto LW. Radiation in the treatment of early supraglottic cancer. Arch Otolaryngol 1984;110(3):208.

    PubMed  CAS  Google Scholar 

  12. Devineni VR, et al. Supraglottic carcinoma: impact of radiation therapy on outcome of patients with positive margins and extracapsular N0dal disease. Laryngoscope 1991;101(7 Pt 1):767–770.

    PubMed  CAS  Google Scholar 

  13. Esposito E, Motta S, Motta G. Exclusive surgery versus postoperative radiotherapy for supraglottic cancer. ORL J OtorhiN0laryngol Relat Spec 2002;64(3):213–218.

    Google Scholar 

  14. Ferlito A, et al. The role of partial laryngeal resection in current management of laryngeal cancer: a collective review. Acta Otolaryngol 2000;120(4):456–465.

    Article  PubMed  CAS  Google Scholar 

  15. Fletcher GH, et al. Reasons for irradiation failure in squamous cell carcinoma of the larynx. Laryngoscope 1975; 85(6):987–1003.

    Article  PubMed  CAS  Google Scholar 

  16. Greisen O, Carl J, Pedersen M. A consecutive series of patients with laryngeal carcinoma treated by primary irradiation. Acta Oncol 1997;36(3):279–282.

    Article  PubMed  CAS  Google Scholar 

  17. Haffty BG, Hurley RA, Peters LG. carcinoma of the larynx treated with hypofractionated radiation and hyperbaric oxygen: long-term tumor control and complications. Int J Radiat Oncol Biol Phys 1999;45(1):13–20.

    PubMed  CAS  Google Scholar 

  18. Harwood AR, et al. Management of early supraglottic laryngeal carcinoma by irradiation with surgery in reserve. Arch Otolaryngol 1983;109(9):583–585.

    PubMed  CAS  Google Scholar 

  19. Hinerman RW, et al. carcinoma of the supraglottic larynx: treatment results with radiotherapy alone or with planned neck dissection. Head Neck 2002;24(5):456–467.

    Article  PubMed  Google Scholar 

  20. Hoekstra CJ, Levendag PC, van Putten WL. Squamous cell carcinoma of the supraglottic larynx without clinically detectable lymph N0de metastases: problem of local relapse and influence of overall treatment time. Int J Radiat Oncol Biol Phys 1990;18(1):13–21.

    PubMed  CAS  Google Scholar 

  21. Johansen LV, Grau C, Overgaard J. Supraglottic carcinoma: patterns of failure and salvage treatment after curatively intended radiotherapy in 410 consecutive patients. Int J Radiat Oncol Biol Phys 2002;53(4):948–958.

    PubMed  Google Scholar 

  22. Jones AS, et al. The treatment of early laryngeal cancers (T1-T2 N0): surgery or irradiation? Head Neck 2004; 26(2):127–135.

    Article  PubMed  Google Scholar 

  23. Jorgensen K, et al. Cancer of the larynx—treatment results after primary radiotherapy with salvage surgery in a series of 1005 patients. Acta Oncol 2002;41(1):69–76.

    Article  PubMed  Google Scholar 

  24. Laccourreye H, et al. Supracricoid laryngectomy with cricohyoidopexy: a partial laryngeal procedure for selected supraglottic and transglottic carcinomas. Laryngoscope 1990;100(7):735–741.

    Article  PubMed  CAS  Google Scholar 

  25. Lutz CK, et al. Supraglottic carcinoma: patterns of recurrence. Ann Otol RhiN0l Laryngol 1990;99(1):12–17.

    CAS  Google Scholar 

  26. MacKenzie RG, et al. Comparing treatment outcomes of radiotherapy and surgery in locally advanced carcinoma of the larynx: a comparison limited to patients eligible for surgery. Int J Radiat Oncol Biol Phys 2000;47(1):65–71.

    PubMed  CAS  Google Scholar 

  27. Makeieff M, et al. Supraglottic hemipharyngolaryngectomy for the treatment of T1 and T2 carcinomas of laryngeal margin and piriform sinus. Head Neck 2004;26(8): 701–705.

    Article  PubMed  Google Scholar 

  28. Marks JE, et al. carcinoma of the supraglottic larynx. AJR Am J RoentgeN0l 1979;132(2):255–260.

    CAS  Google Scholar 

  29. Mendenhall WM, et al. Radiotherapy for carcinoma of the supraglottis. Otolaryngol Clin N0rth Am 1997;30(1):145–161.

    CAS  Google Scholar 

  30. Mendenhall WM, et al. carcinoma of the supraglottic larynx: a basis for comparing the results of radiotherapy and surgery. Head Neck 1990;12(3):204–209.

    Article  PubMed  CAS  Google Scholar 

  31. Mukherji SK, et al. The ability of tumor volume to predict local control in surgically treated squamous cell carcinoma of the supraglottic larynx. Head Neck 2000;22(3):282–287.

    Article  PubMed  CAS  Google Scholar 

  32. Ogura JH, Marks JE, Freeman RB. Results of conservation surgery for cancers of the supraglottis and pyriform sinus. Laryngoscope 1980;90(4):591–600.

    Article  PubMed  CAS  Google Scholar 

  33. Ogura JH, Sessions DG, Ciralsky RH. Supraglottic carcinoma with extension to the aryteN0id. Laryngoscope 1975;85(8):1327–1331.

    Article  PubMed  CAS  Google Scholar 

  34. Prgomet D et al. Videofluoroscopy of the swallowing act after partial supraglottic laryngectomy by CO(2) laser. Eur Arch OtorhiN0laryngol 2002;259(8):399–403.

    Google Scholar 

  35. Rebeiz EE, et al. Preliminary clinical results of window partial laryngectomy: a combined endoscopic and open technique. Ann Otol RhiN0l Laryngol 2000;109(2):123–127.

    CAS  Google Scholar 

  36. Robbins KT, et al. Conservation surgery for T2 and T3 carcinomas of the supraglottic larynx. Arch Otolaryngol Head Neck Surg 1988;114(4):421–426.

    PubMed  CAS  Google Scholar 

  37. Rudert HH, Werner JA, Hoft S. Transoral carbon dioxide laser resection of supraglottic carcinoma. Ann Otol RhiN0l Laryngol 1999;108(9):819–827.

    CAS  Google Scholar 

  38. Schweinfurth JM, Silver SM. Patterns of swallowing after supraglottic laryngectomy. Laryngoscope 2000;110(8): 1266–1270.

    Article  PubMed  CAS  Google Scholar 

  39. Seiden AM, et al. Advanced supraglottic carcinoma: a comparative study of sequential treatment policies. Head Neck Surg 1984;7(1):22–27.

    Article  PubMed  CAS  Google Scholar 

  40. Sessions DG, LeNox J, Spector GJ. Supraglottic laryngeal cancer: analysis of treatment results. Laryngoscope 2005; 115(8):1402–1410.

    Article  PubMed  Google Scholar 

  41. Shimm DS, Coulthard SW. Radiation therapy for squamous cell carcinoma of the supraglottic larynx. Am J Clin Oncol 1989;12(1):17–23.

    Article  PubMed  CAS  Google Scholar 

  42. Suarez C, et al. Supraglottic laryngectomy with or without postoperative radiotherapy in supraglottic carcinomas. Ann Otol RhiN0l Laryngol 1995;104(5):358–363.

    CAS  Google Scholar 

  43. Succo G, et al. Twenty years of experience with Marullo’s supraglottic laryngectomy. Eur Arch OtorhiN0laryngol 1999;256(10):496–500.

    Article  CAS  Google Scholar 

  44. Tu GY, Tang PZ, Jia CY. Horizontovertical laryngectomy for supraglottic carcinoma. Otolaryngol Head Neck Surg 1997;117(3 Pt 1):280–286.

    Article  PubMed  CAS  Google Scholar 

  45. Wang CC, Montgomery WW. Deciding on optimal management of supraglottic carcinoma. Oncology (Williston Park) 1991;5(4):41–46; discussion 46, 49, 53.

    CAS  Google Scholar 

  46. Wang CC, et al. Role of accelerated fractionated irradiation for supraglottic carcinoma: assessment of results. Cancer J Sci Am 1997;3(2):88–91.

    PubMed  CAS  Google Scholar 

  47. Wang CC, Schulz MD, Miller D. Combined radiation therapy and surgery for carcinoma of the supraglottis and pyriform sinus. Am J Surg 1972;124(4):551–554.

    Article  PubMed  CAS  Google Scholar 

  48. Weinstein GS, et al. Laryngeal preservation with supracricoid partial laryngectomy results in improved quality of life when compared with total laryngectomy. Laryngoscope 2001;111(2):191–199.

    Article  PubMed  CAS  Google Scholar 

  49. Wendt CD, et al. Hyperfractionated radiotherapy in the treatment of squamous cell carcinomas of the supraglottic larynx. Int J Radiat Oncol Biol Phys 1989;17(5):1057–1062.

    PubMed  CAS  Google Scholar 

  50. Fu KK, et al. A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. Int J Radiat Oncol Biol Phys 2000;48(1): 7–16.

    Article  PubMed  CAS  Google Scholar 

  51. Gregor RT, et al. Supraglottic laryngectomy with postoperative radiation versus primary radiation in the management of supraglottic laryngeal cancer. Am J Otolaryngol 1996;17(5):316–321.

    Article  PubMed  CAS  Google Scholar 

  52. Coates HL, et al. carcinoma of the supraglottic larynx. A review of 221 cases. Arch Otolaryngol 1976;102(11):686–689.

    PubMed  CAS  Google Scholar 

  53. Goepfert H, et al. Treatment of laryngeal carcinoma with conservative surgery and postoperative radiation therapy. Arch Otolaryngol 1978;104(10):576–578.

    PubMed  CAS  Google Scholar 

  54. Weems DH, et al. Squamous cell carcinoma of the supraglottic larynx treated with surgery and/or radiation therapy. Int J Radiat Oncol Biol Phys 1987;13(10):1483–1487.

    PubMed  CAS  Google Scholar 

  55. SpriaN0 G, et al. Conservative management of T1-T2N0 supraglottic cancer: a retrospective study. Am J Otolaryngol 1997;18(5):299–305.

    Article  PubMed  CAS  Google Scholar 

  56. Orus C, et al. Initial treatment of the early stages (I, II) of supraglottic squamous cell carcinoma: partial laryngectomy versus radiotherapy. Eur Arch OtorhiN0laryngol 2000;257(9):512–516.

    Article  CAS  Google Scholar 

References

  1. Fu KK, et al. A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. Int J Radiat Oncol Biol Phys 2000;48(1):7–16.

    Article  PubMed  CAS  Google Scholar 

  2. Horiot JC, et al. Present status of EORTC trials of hyperfractionated and accelerated radiotherapy on head and neck carcinoma. Recent Results Cancer Res 1994;134:111–119.

    PubMed  CAS  Google Scholar 

  3. Haugen H, Johansson KA, Mercke C. Hyperfractionatedaccelerated or conventionally fractionated radiotherapy for early glottic cancer. Int J Radiat Oncol Biol Phys 2002; 52(1):109–119.

    PubMed  Google Scholar 

  4. Wang CC, Blitzer PH, Suit HD. Twice-a-day radiation therapy for cancer of the head and neck. Cancer 1985;55(9 Suppl): 2100–2104.

    Article  PubMed  CAS  Google Scholar 

  5. Overgaard J, Hansen HS, Specht L, et al., on behalf of the Danish Head and Neck Cancer Study Group. Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial. Lancet 2003;362:933–940.

    Article  PubMed  Google Scholar 

  6. Yamazaki H, Nishiyama K, Tanaka E, Koizumi M, Chatani M. Radiotherapy for early glottic carcinoma (T1N0M0): results of prospective randomized study of radiation fraction size and overall treatment time. Int J Radiat Oncol Biol Phys 2006;64(1):77–82.

    PubMed  Google Scholar 

  7. Sakata K, et al. Accelerated radiotherapy for T1, 2 glottic carcinoma: analysis of results with KI-67 index. Int J Radiat Oncol Biol Phys 2000;47(1):81–88.

    PubMed  CAS  Google Scholar 

  8. Mendenhall WM, et al. T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol 2001;19(20):4029–4036.

    PubMed  CAS  Google Scholar 

  9. Garden AS, Forster K, Wong PF, Morrison WH, Schechter NR, Ang KK. Results of radiotherapy for T2N0 glottic carcinoma: does the “2” stand for twice-daily treatment? Int J Radiat Oncol Biol Phys 2003;55(2):322–328.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA

    Yen-Lin Chen MD

  2. University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Kian Ang MD, PhD (Professor and Distinguished Chair)

  3. Voice Center, Massachusetts Eye and Ear Infirmary, Boston, MA, USA

    Ramon Franco MD (Assistant Professor Otology and Laryngology, Harvard Medical School Director)

  4. Harvard Program in Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, MA, USA

    Jennifer J. Shin MD

Authors
  1. Yen-Lin Chen MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kian Ang MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ramon Franco MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jennifer J. Shin MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Harvard Program in Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Jennifer J. Shin MD

  2. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Christopher J. Hartnick MD, MSE

  3. Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    Gregory W. Randolph MD (Pediatric Otolaryngology) (Pediatric Otolaryngology)

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Chen, YL., Ang, K., Franco, R., Shin, J.J. (2008). Laryngeal Squamous Cell Carcinoma: Early-Stage Disease. In: Shin, J.J., et al. Evidence-Based Otolaryngology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49979-6_30

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-49979-6_30

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-24447-1

  • Online ISBN: 978-0-387-49979-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation