Abstract
A computerized PubMed search of MEDLINE 1966-November 2004 was performed. Articles mapping to any of the following medical subject headings were exploded and combined: “antibiotic prophylaxis,” “antibacterial agents,” “lactams,” “fluoroquinolones,” “macrolides,” “clindamycin.” These articles were then cross-referenced with those mapping to either the exploded medical subject heading “myringoplasty” or textword “myringoplasty.” This process yielded 21 trials. These articles were then reviewed to identify those that met the following inclusion criteria: 1) a distinct patient population under-going myringoplasty alone, 2) intervention with perioperative systemic antibiotics versus placebo or other no-antibiotic control, 3) outcome measured in terms of postoperative surgical site infections1 and/or graft success, 4) randomized controlled trials (RCTs). The outcome of graft success was considered relevant because SSIs have been correlated with graft failure. Articles in which the use of randomization was not clearly specified were excluded.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Surgical site infection (SSI) is the term used by the Centers for Disease Control to specify an infection at the operative site, usually within 30 postoperative days [4]. This term excludes infections at other sites, such as pneumonias.
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References
Carlin WV, Lesser TH, John DG, Fielder C, Carrick DG, Thomas PL, Hill SS. Systemic antibiotic prophylaxis and reconstructive ear surgery. Clin Otolaryngol Allied Sci 1987;12(6):441–446.
John DG, Carlin WV, Lesser TH, Carrick DG, Fielder C. Tympanoplasty surgery and prophylactic antibiotics: surgical results. Clin Otolarngol Allied Scie 1988;13(3):205–207.
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Managram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for prevention of surgical site infection. Centers for Disease Control, US Departnent of Health and Human Services, 1999.
References
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Winerman I, Segal S, Man A. Effectiveness of prophylactic antibiotic treatment in mastoid surgery. Am J Otol 1981; 3(1):65–67.
Managram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for Prevention of Surgical Site Infection. Centers for Disease Control, US Department of Health and Human Services, 1999.
References
Jackson CG. Antimicrobial prophylaxis in ear surgery. Laryngoscope 1988;98(10):1116–1123.
Lindholdt T, Felding JU, Juul A, Kristensen S, Schouenburg P. Efficacy of perioperative ceftazidime in the surgical treatment of chronic otitis media due to Pseudomonas aeriginosa. Arch Otorhinolaryngol 1986;243(3):167–169.
Managram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for Prevention of Surgical Site Infection. Centers for Disease Control, US Department of Health and Human Services, 1999.
References
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Carlin WV, Lesser TH, John DG, Fielder C, Carrick DG, Thomas PL, Hill SS. Systemic antibiotic prophylaxis and reconstructive ear surgery. Clin Otololaryng Allied Sci 1987;12(6):441–446.
Donaldson JA, Snyder IS. Prophylactic chemotherapy in myringoplasty surgery. Laryngoscope 1966;76:1201–1214.
Eschelman. Prophylactic antibiotics in otolaryngologic surgery: a double blind study. Trans Am Acad Ophthalmol Otolaryngol 1971;75(2):387–394.
Govaerts PJ, Raemaekers J, Verlinden A, Kalai M, Somers T, Offeciers FE. Use of antibiotic prophylaxis in ear surgery. Laryngoscope 1998;108(1):107–110.
Jackson CG. Antimicrobial prophylaxis in ear surgery. Laryngoscope 1988;98(10):1116–1123.
John DG, Carlin WV, Lesser TH, Carrick DG, Fielder C. Tympanoplasty surgery and prophylactic antibiotics: surgical results. Clin Otololaryng Allied Sci 1988;13(3): 205–207.
Lindholdt F, Felding JU, Juul A, Kristensen S, Schouenburg P. Efficacy of perioperative ceftazidime in the surgical treatment of chronic otitis media due to Pseudomonas aeriginosa. Arch Otorhinolaryngol 1986;243(3):167–169.
Winerman I, Segal S, Man A. Effectiveness of Prophylactic Antibiotic Treatment in Mastoid Surgery. Am J Otol 1981; 3(1):65–67.
Managram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for Prevention of Surgical Site Infection. Centers for Disease Control, US Department of Health and Human Services, 1999.
Classen DC, Evans RS, Pestotnik SL, Horn SD, Menlove RL, Burke JP. The timing of prophylactic administration of antibiotics and the risk of surgical wound infection. N Engl J Med 1992;326(5):281–286.
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Shin, J.J., Durand, M. (2008). Perioperative Antibiotics for Otologic Surgery. In: Shin, J.J., et al. Evidence-Based Otolaryngology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49979-6_18
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DOI: https://doi.org/10.1007/978-0-387-49979-6_18
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