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Chemokine Receptors in Allergy, Inflammation, and Infectious Disease

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Chemokines

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 14))

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Abstract

Chemokines play an important role in disease by virtue of their effects on immune cells. They mediate their biological effects by acting on G-protein-coupled receptors, which represent one of the most druggable classes of proteins. In this review we will examine the role of chemokines in autoimmunity and inflammation by concentrating on the part they play in the pathophysiology of several diseases including asthma, multiple sclerosis, and rheumatoid arthritis. We will describe the various strategies that pharmaceutical companies have come up with to block the effect of chemokines in driving these disease processes and how they have fared in the clinic. We will also briefly discuss the repurposing of chemokine receptor antagonists in new indications.

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Authors and Affiliations

  1. Leukocyte Biology Section, Faculty of Medicine, National Heart and Lung Institute, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, UK

    James E. Pease

  2. Department of Pharmacology, UC Davis, Davis, CA, 95616, USA

    Richard Horuk

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  1. Dept. of Chemistry and Pharmacy, Friedrich Alexander University, Erlangen, Germany

    Nuska Tschammer

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Pease, J.E., Horuk, R. (2014). Chemokine Receptors in Allergy, Inflammation, and Infectious Disease. In: Tschammer, N. (eds) Chemokines. Topics in Medicinal Chemistry, vol 14. Springer, Cham. https://doi.org/10.1007/7355_2014_39

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