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Lipoylated Peptides and Proteins

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Peptidomimetics II

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 49))

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Abstract

Lipoic acid is a heterocyclic sulfur-containing derivative of octanoic acid that is characterized by a 1,2-dithiolane ring. Found in nature as an essential protein cofactor, lipoic acid is implicated in cellular metabolic reactions. In particular, lipoylation is an essential posttranslational modification involved in cellular energetic metabolism performed by mitochondria. In this chapter, we highlight the different pathways to obtain lipoylated peptides and proteins and the antioxidant properties of lipoic acid analogs, including their therapeutic potential in fields such as autoimmunity.

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Acknowledgments

ANR Chaire d’Excellence PeptKit 2009–2014 (grant n° ANR-09-CEXC-013-01), French-Italian University (Vinci Project grant n° C2-133), and Ente Cassa di Risparmio di Firenze are gratefully acknowledged for their financial support.

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Authors and Affiliations

  1. French-Italian Interdepartmental Laboratory of Peptide and Protein Chemistry and Biology, PeptLab, Sesto Fiorentino, Italy

    Cédric Rentier, Giulia Pacini, Paolo Rovero & Anna-Maria Papini

  2. PeptLab@UCP Platform and Laboratory of Chemical Biology EA4505, University of Cergy-Pontoise, 5 mail Gay-Lussac, 95031, Cergy-Pontoise, France

    Cédric Rentier, Francesca Nuti & Anna-Maria Papini

  3. Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia 13, 50019, Sesto Fiorentino, Italy

    Cédric Rentier, Francesca Nuti & Anna-Maria Papini

  4. Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmaceutical Sciences and Nutraceutics, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy

    Giulia Pacini & Paolo Rovero

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  1. Cédric Rentier
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  2. Giulia Pacini
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  3. Francesca Nuti
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  4. Paolo Rovero
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  5. Anna-Maria Papini
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Correspondence to Anna-Maria Papini .

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Editors and Affiliations

  1. Départemente de Chimie, Université de Montréal Départemente de Chimie, MONTREAL, Québec, Canada

    William Lubell

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Rentier, C., Pacini, G., Nuti, F., Rovero, P., Papini, AM. (2015). Lipoylated Peptides and Proteins. In: Lubell, W. (eds) Peptidomimetics II. Topics in Heterocyclic Chemistry, vol 49. Springer, Cham. https://doi.org/10.1007/7081_2015_186

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