Role of the Innate Immune System and Host-Commensal Mutualism

Rakoff-Nahoum, S.; Medzhitov, R.

doi:10.1007/3-540-30657-9_1

Role of the Innate Immune System and Host-Commensal Mutualism

S. Rakoff-Nahoum¹² &
R. Medzhitov¹²

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1070 Accesses
21 Citations

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 308))

Abstract

Host organisms live in intimate contact with indigenous microflora. The interactions between the host and commensal microbiota are highly complex and heterogeneous. A growing body of evidence indicates that commensal symbionts provide many benefits to the host physiology, particularly in the gastrointestinal system. The molecularmechanisms of themutualistic interactions between the host and commensals are largely unknown but can be due either to bioactivity of the commensals or to the reaction of the host immune system to the commensal-derived products. Recent advances in our understanding of the innate immune system allow re-evaluation of some of the older findings regarding the mechanisms of benefits conferred by microflora. Here we review the examples of the benefits of host-commensal interactions that are due to recognition of commensal microbial products by the host innate immune system.

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Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT, 06510, USA
S. Rakoff-Nahoum & R. Medzhitov

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Department of Immunology and Genomic Medicine, Kyoto University Graduate School of Medicine, Yoshida, Sakyo-ku, Kyoto, 606-8501, Japan
Tasuku Honjo MD, Ph.D.
Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstr. 50-70, 4056, Basel, Switzerland
Fritz Melchers
Max Planck Institute for Infection Biology, Campus Charité, Schumannstrasse 21-22, 10117, Berlin, Germany
Fritz Melchers

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Rakoff-Nahoum, S., Medzhitov, R. (2006). Role of the Innate Immune System and Host-Commensal Mutualism. In: Honjo, T., Melchers, F. (eds) Gut-Associated Lymphoid Tissues. Current Topics in Microbiology and Immunology, vol 308. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-30657-9_1

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