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Delta Opioid Receptors and Cardioprotection

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Delta Opioid Receptor Pharmacology and Therapeutic Applications

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 247))

Abstract

The opioid receptor family, with associated endogenous ligands, has numerous roles throughout the body. Moreover, the delta opioid receptor (DORs) has various integrated roles within the physiological systems, including the cardiovascular system. While DORs are important modulators of cardiovascular autonomic balance, they are well-established contributors to cardioprotective mechanisms. Both endogenous and exogenous opioids acting upon DORs have roles in myocardial hibernation and protection against ischaemia-reperfusion (I-R) injury. Downstream signalling mechanisms governing protective responses alternate, depending on the timing and duration of DOR activation. The following review describes models and mechanisms of DOR-mediated cardioprotection, the impact of co-morbidities and challenges for clinical translation.

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Change history

  • 16 July 2019

    The book was inadvertently published with error in the following chapters.

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Authors and Affiliations

  1. Menzies Health Institute Queensland, Griffith University, Southport, QLD, 4222, Australia

    Louise See Hoe & Jason N. Peart

  2. Critical Care Research Group, The Prince Charles Hospital and The University of Queensland, Chermside, QLD, Australia

    Louise See Hoe

  3. VA San Diego Healthcare System, San Diego, CA, USA

    Hemal H. Patel

  4. Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA

    Hemal H. Patel

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  1. Louise See Hoe
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  2. Hemal H. Patel
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  3. Jason N. Peart
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Correspondence to Jason N. Peart .

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  1. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA

    Emily M. Jutkiewicz

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See Hoe, L., Patel, H.H., Peart, J.N. (2017). Delta Opioid Receptors and Cardioprotection. In: Jutkiewicz, E. (eds) Delta Opioid Receptor Pharmacology and Therapeutic Applications. Handbook of Experimental Pharmacology, vol 247. Springer, Cham. https://doi.org/10.1007/164_2017_6

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