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Delta Opioid Receptor Pharmacology and Therapeutic Applications pp 73–85Cite as

Ligand-Directed Signaling at the Delta Opioid Receptor

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 247))

Abstract

Delta opioid receptors (δORs) regulate a number of physiological functions, and agonists for this receptor are being pursued for the treatment of mood disorders, chronic pain, and migraine. A major challenge to the development of these compounds is that, like many G-protein coupled receptors (GPCRs), agonists at the δOR can induce very different signaling and receptor trafficking events. This concept, known as ligand-directed signaling, functional selectivity, or biased agonism, can result in different agonists producing highly distinct behavioral consequences. In this chapter, we highlight the in vitro and in vivo evidence for ligand-directed signaling and trafficking at the δOR. A number of biological implications of agonist-directed signaling at the δOR have been demonstrated. Importantly, ligand-specific effects can impact both acute behavioral effects of delta agonists, as well as the long-term adaptations induced by chronic drug treatment. A better understanding of the specific signaling cascades that regulate these differential behavioral effects would help to guide rational drug design, ultimately resulting in δOR agonists with fewer adverse effects.

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Acknowledgements

This work was supported by NIH-NIDA grants DA031243 and DA040688.

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Authors and Affiliations

  1. Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA

    Ana Vicente-Sanchez & Amynah A. Pradhan

  2. Department of Psychiatry, UIC, 1601 W Taylor St (MC 912), Chicago, IL, 60612, USA

    Amynah A. Pradhan

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  1. Ana Vicente-Sanchez
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  2. Amynah A. Pradhan
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Correspondence to Amynah A. Pradhan .

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Editors and Affiliations

  1. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA

    Emily M. Jutkiewicz

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Vicente-Sanchez, A., Pradhan, A.A. (2017). Ligand-Directed Signaling at the Delta Opioid Receptor. In: Jutkiewicz, E. (eds) Delta Opioid Receptor Pharmacology and Therapeutic Applications. Handbook of Experimental Pharmacology, vol 247. Springer, Cham. https://doi.org/10.1007/164_2017_39

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