Abstract
Following the recent discovery that white blood cells release melatonin at up to five times the pineal concentration when challenged by a mitogen (PHA) we are investigating whether exposure to EMF in vitro might inhibit this process. It is unsurprising that lymphoctyes should release melatonin, a powerful antioxidant and anti-metastatic agent, since it would be a natural addition to their defensive armoury. If the hypothesis proves correct this would provide a simple mechanism of interaction explaining how EMF exposure is associated with childhood cancers and other immunological disorders.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Blank, M., 1995, Electrical stimulation of protein synthesis in muscle, Adv Chem., 250: 143–153.
Blank, M., Goodman, R., 2004, Initial Interactions in Electromagnetic Field-induced Biosynthesis, Cell Physiol, 199: 359–363.
Blank, M., Soo, L., 1992, The threshold for alternating current inhibition of the Na, K, ATPase, Bioelectromagnetics, 13: 329–333.
Blank, M., Soo, L., 2001, Optimal frequencies for magnetic acceleration of cytochrome oxidase and Na, K, ATPase reactions, Bioelectrochem, 53: 171–174.
Carrillo-Vico, A., Calvo, J.R., et al., 2004, Evidence of melatonin synthesis by human lymphocytes and its physiological significance and possible role as intracrine, automne and/or paracrine substance. FASEB J., 18(3): 537–539.
Coghill, R.W., Galonja-Coghill, T., 2000, Protective effect of a donor's endogenous electric field on human peripheral blood lymphocytes. Electro and Magneto Biology, 19(1): 46–59.
Leszczynski, D., Joenvaara, S., Reivinen, J., Kuokka, R., 2002, Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: Molecular mechanisms for cancer and blood brain barrier related effects. Differentiation, 70: 120–129.
Lin, H., Han, L., Blank, M., Head, M., Goodman, R., 1998a, Magnetic field activation of protein-DNA binding., J, Cell Biochem, 70: 297–303.
Lin, H., Head, M., Blank, M., Jin, M., Goodman, R., 1998b, Myc-Mediated transactivation of HSP70 expression following exposure to magnetic fields. J. Cell Biochem., 69: 181–188.
Lin, H., Blank, M., Goodman, R., 1999, A magnetic field responsive domain in the human HSP70 promoter. J. Cell Biochem., 75: 170–176.
Lin, H., Blank, M., Rossol-Hasterlth, K., Goodman, R., 2001, Regulating genes with electromagnetic response elements. J. Cell Biochem., 81(1): 143–148.
Lyle, D.B., Schecter, P., et al., 1983, Suppression of T-lymphocyte cytotoxicity following exposure to sinusoidally amplitude-modulated fields. Bioelectromagnetics, 4: 281–292.
Lyle, D.B., Ayotte, R.D., et al., 1988, Suppression of T-Lymphocyte cytotoxicity following exposure to 60Hz sinusoidal electric fields. Bioelectromagnetics, 9: 303–313.
Pette, D., Vrbova, G., 1992, Adaptation of mammalian skeletal muscle to chronic electrical stimulation. Physiolog Biochem Pharmacol, 120: 115–202.
Stevens, R.G., Wilson, B.W., Anderson, L.E., 1997, in: The Melatonin Hypothesis: Breast cancer and the use of electric power. Battellee Press, Columbus, Ohio USA.
Traikov, L., Ushiyama, A., Sasaki, R., Lawlor, G.F., Okhubo, C., 2005, Changes in magnitude of arteriole vasomotion during and after ELF-EMF exposure in vivo. Proceedings of UNESCO/WHO Seminar and NATO ARW, Molecular and Cellular Mechanisms of Biological Effects of EMF, Yerevan, March 2005. p 108.
Weisbrot, D., Lin., H., Ye, L., Blank, M., Goodman, R., 2003, Effects of mobile phone radiation on growth and development in Drosophjila melanogaster. J Cell Biochem., 89: 48–55.
Wilson, B.W., Anderson, L.E., 1990, ELF electromagnetic field effects on the pineal gland, in: ELF electromagnetic fields: the question of cancer, Wilson, Stevens et al., eds., Batteile, Columbus, Ohio.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer
About this paper
Cite this paper
COGHILL, R., BAGHURST, R. (2006). INHIBITION OF MELATONIN SYNTHESIS IN HUMAN PERIPHERAL BLOOD LYMPHOCYTES BY EMF: A MECHANISM OF INTERACTION?. In: Ayrapetyan, S.N., Markov, M.S. (eds) BIOELECTROMAGNETICS Current Concepts. NATO Security Through Science Series. Springer, Dordrecht . https://doi.org/10.1007/1-4020-4278-7_27
Download citation
DOI: https://doi.org/10.1007/1-4020-4278-7_27
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-4276-8
Online ISBN: 978-1-4020-4278-2
eBook Packages: MedicineMedicine (R0)