Skip to main content

INHIBITION OF MELATONIN SYNTHESIS IN HUMAN PERIPHERAL BLOOD LYMPHOCYTES BY EMF: A MECHANISM OF INTERACTION?

  • Conference paper
BIOELECTROMAGNETICS Current Concepts

Part of the book series: NATO Security Through Science Series ((NASTB))

Abstract

Following the recent discovery that white blood cells release melatonin at up to five times the pineal concentration when challenged by a mitogen (PHA) we are investigating whether exposure to EMF in vitro might inhibit this process. It is unsurprising that lymphoctyes should release melatonin, a powerful antioxidant and anti-metastatic agent, since it would be a natural addition to their defensive armoury. If the hypothesis proves correct this would provide a simple mechanism of interaction explaining how EMF exposure is associated with childhood cancers and other immunological disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Blank, M., 1995, Electrical stimulation of protein synthesis in muscle, Adv Chem., 250: 143–153.

    Article  CAS  Google Scholar 

  • Blank, M., Goodman, R., 2004, Initial Interactions in Electromagnetic Field-induced Biosynthesis, Cell Physiol, 199: 359–363.

    Article  CAS  Google Scholar 

  • Blank, M., Soo, L., 1992, The threshold for alternating current inhibition of the Na, K, ATPase, Bioelectromagnetics, 13: 329–333.

    Article  PubMed  CAS  Google Scholar 

  • Blank, M., Soo, L., 2001, Optimal frequencies for magnetic acceleration of cytochrome oxidase and Na, K, ATPase reactions, Bioelectrochem, 53: 171–174.

    Article  CAS  Google Scholar 

  • Carrillo-Vico, A., Calvo, J.R., et al., 2004, Evidence of melatonin synthesis by human lymphocytes and its physiological significance and possible role as intracrine, automne and/or paracrine substance. FASEB J., 18(3): 537–539.

    PubMed  CAS  Google Scholar 

  • Coghill, R.W., Galonja-Coghill, T., 2000, Protective effect of a donor's endogenous electric field on human peripheral blood lymphocytes. Electro and Magneto Biology, 19(1): 46–59.

    Google Scholar 

  • Leszczynski, D., Joenvaara, S., Reivinen, J., Kuokka, R., 2002, Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: Molecular mechanisms for cancer and blood brain barrier related effects. Differentiation, 70: 120–129.

    Article  PubMed  CAS  Google Scholar 

  • Lin, H., Han, L., Blank, M., Head, M., Goodman, R., 1998a, Magnetic field activation of protein-DNA binding., J, Cell Biochem, 70: 297–303.

    Article  CAS  Google Scholar 

  • Lin, H., Head, M., Blank, M., Jin, M., Goodman, R., 1998b, Myc-Mediated transactivation of HSP70 expression following exposure to magnetic fields. J. Cell Biochem., 69: 181–188.

    Article  CAS  Google Scholar 

  • Lin, H., Blank, M., Goodman, R., 1999, A magnetic field responsive domain in the human HSP70 promoter. J. Cell Biochem., 75: 170–176.

    Article  PubMed  CAS  Google Scholar 

  • Lin, H., Blank, M., Rossol-Hasterlth, K., Goodman, R., 2001, Regulating genes with electromagnetic response elements. J. Cell Biochem., 81(1): 143–148.

    Article  PubMed  CAS  Google Scholar 

  • Lyle, D.B., Schecter, P., et al., 1983, Suppression of T-lymphocyte cytotoxicity following exposure to sinusoidally amplitude-modulated fields. Bioelectromagnetics, 4: 281–292.

    PubMed  CAS  Google Scholar 

  • Lyle, D.B., Ayotte, R.D., et al., 1988, Suppression of T-Lymphocyte cytotoxicity following exposure to 60Hz sinusoidal electric fields. Bioelectromagnetics, 9: 303–313.

    Article  PubMed  CAS  Google Scholar 

  • Pette, D., Vrbova, G., 1992, Adaptation of mammalian skeletal muscle to chronic electrical stimulation. Physiolog Biochem Pharmacol, 120: 115–202.

    CAS  Google Scholar 

  • Stevens, R.G., Wilson, B.W., Anderson, L.E., 1997, in: The Melatonin Hypothesis: Breast cancer and the use of electric power. Battellee Press, Columbus, Ohio USA.

    Google Scholar 

  • Traikov, L., Ushiyama, A., Sasaki, R., Lawlor, G.F., Okhubo, C., 2005, Changes in magnitude of arteriole vasomotion during and after ELF-EMF exposure in vivo. Proceedings of UNESCO/WHO Seminar and NATO ARW, Molecular and Cellular Mechanisms of Biological Effects of EMF, Yerevan, March 2005. p 108.

    Google Scholar 

  • Weisbrot, D., Lin., H., Ye, L., Blank, M., Goodman, R., 2003, Effects of mobile phone radiation on growth and development in Drosophjila melanogaster. J Cell Biochem., 89: 48–55.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, B.W., Anderson, L.E., 1990, ELF electromagnetic field effects on the pineal gland, in: ELF electromagnetic fields: the question of cancer, Wilson, Stevens et al., eds., Batteile, Columbus, Ohio.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer

About this paper

Cite this paper

COGHILL, R., BAGHURST, R. (2006). INHIBITION OF MELATONIN SYNTHESIS IN HUMAN PERIPHERAL BLOOD LYMPHOCYTES BY EMF: A MECHANISM OF INTERACTION?. In: Ayrapetyan, S.N., Markov, M.S. (eds) BIOELECTROMAGNETICS Current Concepts. NATO Security Through Science Series. Springer, Dordrecht . https://doi.org/10.1007/1-4020-4278-7_27

Download citation

  • DOI: https://doi.org/10.1007/1-4020-4278-7_27

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-4276-8

  • Online ISBN: 978-1-4020-4278-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics