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The Multiple Cellular Functions of TFIIIA

  • Chapter
Zinc Finger Proteins

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

Transcription factor IIIA (TFIIIA) is a single polypeptide with several distinct functions in the cell. In this chapter I will review the role of TFIIIA in transcription initiation of the 5S rRNA gene. I will also describe the model by which TFIIIA associates with the 5S rRNA itself to regulate ribosome biosynthesis and assembly. Finally, I will compare these functions of TFIIIA in various eukaryotic cells, from yeast to vertebrate. In all cases, the part played by the protein’s zinc fingers will be emphasized.

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Authors and Affiliations

  1. Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Natalie Kuldell

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  1. Natalie Kuldell
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Editors and Affiliations

  1. Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA

    Shiro Iuchi

  2. Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Natalie Kuldell

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Kuldell, N. (2005). The Multiple Cellular Functions of TFIIIA. In: Iuchi, S., Kuldell, N. (eds) Zinc Finger Proteins. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-27421-9_26

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