Abstract
The wig-1 gene (for Wild type p53-Induced Gene 1) is a direct transcriptional target of wild type p53. Wig-1 is a highly conserved unusual nuclear zinc finger protein that binds double stranded RNA. Overexpression of Wig-1 inhibits cell growth. Wig-1 has been implicated in neuronal apoptosis and stem cell proliferation/differentiation. Elucidation of the biological function of Wig-1 should provide new insights into the p53 tumor suppressor pathway.
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© 2005 Landes Bioscience/Eurekah.com and Kluwer Academic/Plenum Publishers
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Mendez-Vidal, C., Hellborg, F., Wilhelm, M.T., Tarkowska, M., Wiman, K.G. (2005). Wig-1, a p53-Induced Zinc Finger Protein that Binds Double Stranded RNA. In: Iuchi, S., Kuldell, N. (eds) Zinc Finger Proteins. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-27421-9_12
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DOI: https://doi.org/10.1007/0-387-27421-9_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-48229-8
Online ISBN: 978-0-387-27421-8
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