Summary
The SCAD deficient mouse model has been useful to investigate mechanisms of deficient fatty acid oxidation disease in human patients. This mouse model has been thor-oughly characterized and is readily available from the Jackson Laboratory. Using the new technologies of gene-knockout mouse modeling, we envisage developing additional members of the acyl-CoA dehydrogenase family of enzyme deficiencies in mice and fur-thering our understanding of fatty acid metabolism in health and disease.26
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Wood, P.A., Kelly-Kurtz, C.L., Hinsdale, M.E., Hamm, D.A., Rhead, W.J. (2002). Lessons Learned from The Mouse Model of Short-Chain Acyl-CoA Dehydrogenase Deficiency. In: Quant, P.A., Eaton, S. (eds) Current Views of Fatty Acid Oxidation and Ketogenesis. Advances in Experimental Medicine and Biology, vol 466. Springer, Boston, MA. https://doi.org/10.1007/0-306-46818-2_46
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DOI: https://doi.org/10.1007/0-306-46818-2_46
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