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Melatoninand Cardiovascular Function

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Melatonin After Four Decades

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 460))

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References

  1. Abete, P., Bianco, S., Calabrese, C., Napoli, C., Cacciatore, F., Ferrara, N., and Rengo, F. Effects of melatonin in isolated rat papillary muscle. FEBS Lett. 412:79–85, 1997.

    Article  PubMed  CAS  Google Scholar 

  2. Behar, S., Halabi, M., Reicher-Reiss, H., Zion, M., Kaplinsky, E., Mandelzweig, L., and Goldbourt, U. Circadian variation and possible external triggers of onset of myocardial infarction. SPRINT Study Group. Am. J. Med. 94:395–400, 1993.

    CAS  Google Scholar 

  3. Birau, N., Petterssen, U., Meyer, C., and Gottschalk, J. Hypotensive effect of melatonin in essential hypertension. IRCS Med. Sci. 9:906.

    Google Scholar 

  4. Bosman, H., Dormehl, I.C., Hugo, N., Redelinghuys, I.F., and Theron, J.J. The effect of intravenous administration of melatonin on cardiovascular parameters of the baboon Papio ursinus. J. Pineal Res.11:179–181, 1991.

    PubMed  CAS  Google Scholar 

  5. Brugger, P., Marktl, W., and Herold, M. Impaired nocturnal secretion of melatonin in coronary heart disease. The Lancet 345:1408, 1995.

    CAS  Google Scholar 

  6. Brun, J., Claustrat, B., Saddier, P., and Chazot, G. Nocturnal melatonin excretion is decreased in patients with migraine without aura attacks associated with menses. Cephalalgia 15:136–139, 1995.

    Article  PubMed  CAS  Google Scholar 

  7. Cagnacci, A., Arangino, S., Angiolucci, M., Maschio, E., and Melis, G.B. Influences of melatonin administration on the circulation of women. Am. J. Physiol. 43:R335–R338, 1998.

    Google Scholar 

  8. Chan, T.Y. and Tang, P.L. Effect of melatonin on the maintenance of cholesterol homeostasis in the rat. Endocrine Res. 21:681–696, 1995.

    CAS  Google Scholar 

  9. Capsoni, S., Viswanathan, M., de Oliveira, A.M., and Saavedra, J.M. Characterization of melatonin receptors and signal transduction system in rat arteries forming the circle of Willis. Endocrinol. 135:373–378, 1994.

    Article  CAS  Google Scholar 

  10. Capsoni, S., Stankov, B.M., and Fraschini, F. Reduction of regional cerebral blood flow by melatonin in young rats. NeuroReport 6:1346–1348, 1995.

    Article  PubMed  CAS  Google Scholar 

  11. Chuang, J.I., Chen, S.S., and Lin, M.T. Melatonin decreases brain serotonin release, arterial pressure and heart rate in rats. Pharmacol. 47:91–97, 1993.

    Article  CAS  Google Scholar 

  12. Cunnane, S.C., Manku, M.S., Oka, M., and Horrobin, D.F. Enhanced vascular reactivity to various vasoconstrictor agents following pinealectomy in the rat: role of melatonin. Can. J. Physiol. Pharmacol. 58:287–293, 1980.

    PubMed  CAS  Google Scholar 

  13. Doolen, S., Duckles, S.P., Geary, G.G., and Krause, D.N. Melatonin mediates vascular dilation via a distinct melatonin receptor sub-type. Soc. Neurosci. Abstr. 23:1517, 1997.

    Google Scholar 

  14. Doolen, S., Krause, D.N., Dubocovich, M.L., and Duckles, S.P. Melatonin mediates two distinct responses in vascular smooth muscle. Eur. J. Pharmacol. 345:67–69, 1998a.

    Article  PubMed  CAS  Google Scholar 

  15. Doolen, S., Krause, D.N., and Duckles, S.P. Gender differences in response to melatonin. Soc. Neurosci.Abstr. 21:1406, 1995.

    Google Scholar 

  16. Doolen, S., Krause, D.N., and Duckles, S.P. Estradiol modulates vascular response to melatonin in rat caudal artery. Am. J. Physiol. 276:H1281–1288, 1999.

    PubMed  CAS  Google Scholar 

  17. Dubocovich, M.L., Cardinali, D.P., Guardiola-Lemaitre, B., Hagan, R.M., Krause, D.N., Sugden, D., Yocca, F.D., and Vanhoutte, P.M. Melatonin Receptors. The IUPHAR Compendium of Receptor Characterization and Classification. IUPHAR Media, London, 1998, pp. 187–193.

    Google Scholar 

  18. Dubocovich, M.L., Masana, M.I., Iacob, S., and Sauri, D.M. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn-Schmiedeberg’s Arch. Pharmacol.355:365–375, 1997

    Article  CAS  Google Scholar 

  19. Duckles, S.P., Barrios, V.E., Doolen, S., and Krause, D.N. Melatonin receptors potentiate contractile responses to adrenergic nerve stimulation in rat caudal artery. Proc. West. Pharmacol. Soc. 38:101–102, 1995.

    PubMed  CAS  Google Scholar 

  20. Esquifino, A., Agrasal, C., Velazquez, E., Villanua, M.A., and Cardinali, D.P. Effect of melatonin on serum cholesterol and phospholipid levels, and on prolactin, thyroid-stimulating hormone and thyroid hormone levels, in hyperprolactinemic rats. Life Sciences 61:1051–1058, 1997.

    Article  PubMed  CAS  Google Scholar 

  21. Evans, B.K., Mason, R., and Wilson, V.G. Evidence for direct vasoconstriction of melatonin in “pressurized” segments of isolated caudal artery from juvenile rats. Naunyn-Schmiedebergs Arch. Pharmacol.346:362–365, 1992.

    PubMed  CAS  Google Scholar 

  22. Fiorina, P., Lattuada, G., Ponari, O., Silvestrini, C., and Dall’Aglio, P. Impaired nocturnal melatonin excretion and changes of immunological status in ischaemic stroke patients. The Lancet 347:692–693, 1996.

    Article  CAS  Google Scholar 

  23. Gallerani, M., Manfredini, R., Ricci, L., Cocurullo, A., Goldoni, C., Bigoni, M., and Fersini, C. Chronobiological aspects of acute cerebrovascular diseases. Acta Neurol. Scand. 87:482–487, 1993.

    PubMed  CAS  Google Scholar 

  24. Geary, G.G., Krause, D.N., and Duckles, S.P. Melatonin directly constricts rat cerebral arteries through modulation of potassium channels. Am. J. Physiol. 273:H1530–H1536, 1997.

    PubMed  CAS  Google Scholar 

  25. Geary, G.G., Duckles, S.P., and Krause, D.N. Effect of melatonin in the rat tail artery: Role of K+ channels and endothelial factors. Br. J. Pharmacol. 123:1533–1540, 1998.

    Article  PubMed  CAS  Google Scholar 

  26. Holmes, S.W. and Sugden, D. The effect of melatonin on pinealectomy-induced hypertension in the rat. Br. J. Pharmacol. 56:360P, 1976.

    Google Scholar 

  27. Hutcheson, I.R. and Griffith, T.M. Heterogeneous population of K+ channels mediate EDRF release to flow but not agonists in rabbit aorta. Am. J. Physiol. 266:H590–H596, 1994.

    PubMed  CAS  Google Scholar 

  28. K.-Laflamme, A., Wu, L.Y., Foucart, S., and de Champlain, J. Impaired basal sympathetic tone and alpha 1-adrenergic responsiveness in association with the hypotensive effect of melatonin in spontaneously hypertensive rats. Am. J. Hypertension 11:219–229, 1998.

    Article  CAS  Google Scholar 

  29. Karppanen, H., Airaksinen, M.M., and Sarkimaki, I. Effects in rats of pinealectomy and oxypertine on spontaneous locomotor activity and blood pressure during various light schedules. Ann. Med. Exp. Biol. Fenn. 51:93, 1973.

    PubMed  CAS  Google Scholar 

  30. Kawashima, K., Miwa, Y., Fujimoto, K., Ochata, H., Nishino, H., and Koike, H. Antihypertensive action of melatonin in the spontaneously hypertensive rat. Clin. Exp. Hypertens. Ther. Pract. A9:1121–1131, 1987.

    CAS  Google Scholar 

  31. Kitay, J.I. and Altschule, M.D. The Pineal Gland, A Review of the Physiologic Literature, Harvard University Press, Cambridge, MA, pp. 69–70,1954.

    Google Scholar 

  32. Kelly-Hayes, M., Wolf, P.A., Kase, C.S., Brand, F.N., McGuirk, J.M., and D’Agostino, R.B. Temporal patterns of stroke onset. The Framingham Study. Stroke 26:1343–1347, 1995.

    CAS  Google Scholar 

  33. Krause, D.N. and Dubocovich, M.L. Regulatory sites in the melatonin system of mammals. Trends Neurosci. 13:464–470, 1990.

    Article  PubMed  CAS  Google Scholar 

  34. Krause, D.N. and Dubocovich, M.L. Melatonin receptors. Ann. Rev. Pharmacol. Toxicol. 31:549–568, 1991.

    Article  CAS  Google Scholar 

  35. Krause, D.N., Barrios, V.E., and Duckles, S.P. Melatonin receptors mediate potentiation of contractile responses to adrenergic nerve stimulation in rat caudal artery. Eur. J. Pharmacol. 276:207–213, 1995.

    Article  PubMed  CAS  Google Scholar 

  36. Krause, D.N., Doolen, S., and Duckles, S.P. Vascular melatonin receptor subtypes: function, pharmacology and effect of estrogen. Naunyn-Schmiedeberg’s Arch. Pharmacol. 358 (Suppl. 1):R550, 1998.

    Google Scholar 

  37. Krause, D.N., Dubocovich, M.L., Edvinsson, L., Geary, G.G., Masana, M.I., and Duckles, S.P. ML1A melatonin receptors in human and rat cerebral and peripheral arteries: mRNA expression and functional pharmacology. Soc. Neurosci. Abstr. 22:1400, 1996.

    Google Scholar 

  38. Laitinen, J.T., Viswanathan, M., Vakkuri, O., and Saavedra, J.M. Differential regulation of the rat melatonin receptors: selective age-associated decline and lack of melatonin-induced changes. Endocrinology 130:2139–2144, 1992

    Article  PubMed  CAS  Google Scholar 

  39. Mahle, C.D., Goggins, G.D., Agarwal, P., Ryan, E., and Watson, A.J. Melatonin modulates vascular smooth muscle tone. J. Biol. Rhythms 12:690–696, 1997.

    PubMed  CAS  Google Scholar 

  40. Masana, M.I., Al-Ghoul, W., and Dubocovich, M.L. MT1 and MT2 melatonin receptor expression in mammalian vasculature and superior cervical ganglion. Naunyn-Schmiedeberg’s Arch. Pharmacol. 358 (Suppl. 1):R72, 1998.

    Google Scholar 

  41. Maywood, E.S., Bittman, E.L., Ebling, F.J., Barrett, P., Morgan, P., and Hastings, M.H. Regional distribution of iodomelatonin binding sites within the suparchiasmatic nucleus of the Syrian hamster and the Siberian hamster. J. Neuroendocrinol. 7:215–223, 1995.

    PubMed  CAS  Google Scholar 

  42. Nelson, M.T. and Quayle, J.M. Physiological roles and properties of potassium channels in arterial smooth muscle. Am. J. Physiol. 268:C799–C822.

    Google Scholar 

  43. Regrigny, O., Delagrange, P., Scalbert, E., Atkinson, J., and Lartaud-Idjouadiene, I. Melatonin improves cerebral circulation security margin in rats. Am. J. Physiol. 275:H139–H144, 1998.

    PubMed  CAS  Google Scholar 

  44. Satake, N., Shibata, S., and Takagi, T. The inhibitory action of melatonin on the contractile response to 5-hydroxytryptamine in various isolated vascular smooth muscles. Gen. Pharmacol. 17553–558, 1986.

    PubMed  CAS  Google Scholar 

  45. Satake, N., Oe, H., Sawada, T., and Shibata, S. The mode of vasorelaxing action of melatonin in rabbit aorta. Gen. Pharmacol. 22:219–222, 1991.

    PubMed  CAS  Google Scholar 

  46. Seltzer, A., Viswanathan, M., and Saavedra, J.M. Melatonin-binding sites in brain and caudal arteries of the female rat during the estrous cycle and after estrogen administration. Endocrinology 1301896–1902, 1992

    Article  PubMed  CAS  Google Scholar 

  47. Shibata, S., Satake, N., Takagi, T., and Usui, H. Vasorelaxing action of melatonin in rabbit basilar artery. Gen.Pharmacol. 20:677–680, 1989.

    PubMed  CAS  Google Scholar 

  48. Stankov, B., Capsoni, S., Lucini, V., Pauteck, J., Gatti, S., Gridelli, B., Biella, G., Cozzi, B., and Fraschini, E Autoradiographic localization of the putative melatonin receptor in the brains of two old world primates: Cercopithecus wethiops and Papio ursinus. Neuroscience 52:459–468, 1993.

    Article  PubMed  CAS  Google Scholar 

  49. Terzolo, M., Piovesan, A., Puligheddu, B., Torta, M., Osella, G., Paccoti, P., and Angeli, A. Effects of long-term, low-dose, time-specified melatonin administration on endocrine and cardiovascular variables in adult men. J. Pineal Res. 9:113–124, 1990.

    PubMed  CAS  Google Scholar 

  50. Ting, K.N., Dunn, W.R., Davies, D.J., Sugden, D., Delegrange, P., Guardiola-Lemaitre, B., Scalbert, E., and Wilson, V.G. Studies on the vasoconstrictor action of melatonin and putative melatonin receptor ligands in the tail artery of juvenile Wistar rats. Br. J. Pharmacol. 122:1299–1306, 1997.

    Article  PubMed  CAS  Google Scholar 

  51. Veerman, D.P., Imholz, B.P., Wieling, W., Wesseling, K.H., and van Montfrans, G.A. Circadian profile of systemic hemodynamics. Hypertension 26:55–59, 1995.

    PubMed  CAS  Google Scholar 

  52. Viswanathan, M., Hissa, R., and George, J.C. Suppression of sympathetic nervous system by short photoperiod and melatonin in the Syrian hamster. Life Sci. 38:73–79, 1986.

    Article  PubMed  CAS  Google Scholar 

  53. Viswanathan, M., Laitinen, J.T., and Saavedra, J.M. Expression of melatonin receptors in arteries involved in thermoregulation. Proc. Natl. Acad. Sci. USA 87:6200–6203, 1990.

    PubMed  CAS  Google Scholar 

  54. Viswanathan, M., Laitinen, J.T., and Saavedra, J.M. Differential expression of melatonin receptors in spontaneously hypertensive rats. Neuroendocrinology 56:864–870, 1992.

    PubMed  CAS  Google Scholar 

  55. Viswanathan, M., Scalbert, E., Delagrange, P., Guardiola-Lemaitre, B., and Saavedra, J.M. Melatonin receptors mediate contraction of a rat cerebral artery. Neuroreport 8:3847–3849, 1997.

    PubMed  CAS  Google Scholar 

  56. Weekley, L.B. Pharmacological studies on the mechanism of melatonin-induced vasorelaxation in rat aorta. J. Pineal Res. 19:133–138, 1995.

    PubMed  CAS  Google Scholar 

  57. Zanaboni, A. and Zanaboni-Muciaccia, W. Experimental hypertension in pinealectomized rats. Life Sci. 6:2327–2331, 1967.

    Google Scholar 

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Krause, D.N., Geary, G.G., Doolen, S., Duckles, S.P. (2002). Melatoninand Cardiovascular Function. In: Olcese, J. (eds) Melatonin After Four Decades. Advances in Experimental Medicine and Biology, vol 460. Springer, Boston, MA. https://doi.org/10.1007/0-306-46814-X_32

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  • DOI: https://doi.org/10.1007/0-306-46814-X_32

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