Skip to main content

Mechanisms of Melatonin Action in the Pituitary and SCN

  • Chapter
Melatonin After Four Decades

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 460))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Berridge M.J. 1993 Inositol trisphosphate and calcium signalling. Nature 361:315–325.

    Article  PubMed  CAS  Google Scholar 

  2. Carty D.J., Padrell E., Codina J., Birnbaumer L., Hildebrandt J.D., and Iyengar R. 1990 Distinct guanine nucleotide binding and release properties of the three Gi proteins. J Biol Chem 265:6268–6273.

    PubMed  CAS  Google Scholar 

  3. Chang J.P., Stojilkovic S.S., Graeter J.S., and Catt K.J. 1988 Gonadotropin-releasing hormone stimulates luteinizing hormone secretion by extracellular calcium-dependent and-independent mechanisms. Endocrinology 123:87–97.

    PubMed  CAS  Google Scholar 

  4. Conn P.M., Huckle W.R., Andrews W.V., and McArdle C.A. 1987 The molecular mechanism of action of gonadotropin releasing hormone (GnRH) in the pituitary. Recent Prog Horm Res 43:29–68.

    PubMed  CAS  Google Scholar 

  5. Earnest D.J. and Sladek C.D. 1986 Circadian rhythms of vasopressin release from individual rat suprachiasmatic explants in vitro. Brain Res 382:129–133.

    Article  PubMed  CAS  Google Scholar 

  6. Green D.J. and Gillette R. 1982 Circadian rhythm of firing rate recorded from single cells in the rat suprachiasmatic brain slice. Brain Res 245:198–200.

    Article  PubMed  CAS  Google Scholar 

  7. Izumi S., Stojilkovic S.S., and Catt K.J. 1989 Calcium mobilization and influx during the biphasic cytosolic calcium and secretory responses in agonist-stimulated pituitary gonadotrophs. Arch Biochem Biophys 275:410–428.

    Article  PubMed  CAS  Google Scholar 

  8. Liu C., Weaver D.R., Jin X.W., Shearman L.P., Pieschl R.L., Gribkoff V.K., and Reppert S.M. 1997 Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron 19:91–102.

    PubMed  CAS  Google Scholar 

  9. Martin J.E., Engel J.N., and Klein D.C. 1977 Inhibition of the in vitro pituitary response to luteinizing hormone-releasing hormone by melatonin, serotonin and 5-methoxytryptamine. Endocrinology 100:675–680.

    PubMed  CAS  Google Scholar 

  10. Martin J.E., McKellar S., and Klein D.C. 1980 Melatonin inhibition of the in vivo pituitary response to luteinizing hormone-releasing hormone in the neonatal rat. Neoroendocrinology 31:13–17.

    CAS  Google Scholar 

  11. Martin J.E., McKeel D.W., and Jr., Sattler C. 1982 Melatonin directly inhibits rat gonadotroph cells. Endocrinology110:1079–1084.

    PubMed  CAS  Google Scholar 

  12. Martin J.E. and Klein D.C. 1976 Melatonin inhibition of the neonatal pituitary response to luteinizing hormone-releasing factor. Science 191:301–302.

    PubMed  CAS  Google Scholar 

  13. Martin J.E. and Sattler C. 1979 Developmental loss of the acute inhibitory effect of melatonin on the in vitro pituitary luteinizing hormone and folliclestimulating hormone responses to luteinizing hormone releasing hormone. Endocrinology 105:107–112.

    Google Scholar 

  14. Martin J.E. and Sattler C. 1982 Selectivity of melatonin pituitary inhibition for luteinizing hormone-releasing hormone. Neuroendocrinology 34:112–116.

    PubMed  CAS  Google Scholar 

  15. Morgan P.J., Lawson W., Davidson G., and Howell H.E. 1989 Guanine nucleotides regulate the affinity of melatonin receptors on the ovine pars tuberalis. Neuroendocrinology 50:359–362.

    PubMed  CAS  Google Scholar 

  16. Murakami N., Takamure M., Takahashi K., Utunomiya K., Kuroda H., and Etoh T. 1991 Long-term cultured neurons from rat suprachiasmatic nucleus retain the capacity for circadian oscillation of vasopressin release. Brain Res 545:347–350.

    Article  PubMed  CAS  Google Scholar 

  17. Padrell E., Carty D.J., Moriarty T.M., Hildebrandt J.D., Landau E.M., and Iyengar R. 1991 Two forms of the bovine brain Go that stimulate the inositol trisphosphate-mediated C1-currents in Xenopus oocytes. Distinct guanine nucleotide binding properties. J Biol Chem 266:9771–9777.

    PubMed  CAS  Google Scholar 

  18. Shibata S., Cassone V.M., and Moore R.Y. 1989 Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro. Neurosci Lett 97:140–144.

    Article  PubMed  CAS  Google Scholar 

  19. Slanar O., Zemkova H., and Vanecek J. 1997 Melatonin inhibits GnRH-induced Ca2+ mobilization and influx through voltage-regulated channels. Biol Signals 6:284–290.

    Article  PubMed  CAS  Google Scholar 

  20. Stehle J., Vanecek J., and Vollrath L. 1989 Effects of melatonin on spontaneous electrical activity of neurons in rat suprachiasmatic nuclei: an in vitro iontophoretic study. J Neural Transm 78:173–177.

    Article  PubMed  CAS  Google Scholar 

  21. Tasaka K., Stojilkovic S.S., Izumi S., and Catt K.J. 1988 Biphasic activation of cytosolic free calcium and LH responses by gonadotropin-releasing hormone. Biochem Biophys Res Commun 154:398–403.

    Article  PubMed  CAS  Google Scholar 

  22. Vanecek J., Pavlik A., and Illnerova H. 1987 Hypothalamic melatonin receptor sites revealed by autoradiography. Brain Res 435:359–362.

    Article  PubMed  CAS  Google Scholar 

  23. Vanecek J. 1988 The melatonin receptors in rat ontogenesis. Neuroendocrinology 48:201–203.

    PubMed  CAS  Google Scholar 

  24. Vanecek J. 1988 Melatonin binding sites. J Neurochem 51:1436–1440.

    Article  PubMed  CAS  Google Scholar 

  25. Vanecek J. 1995 Melatonin inhibits increase of intracellular calcium and cyclic AMP in neonatal rat pituitary via independent pathways. Mol Cell Endocrinol 107:149–153.

    Article  PubMed  CAS  Google Scholar 

  26. Vanecek J. 1998 Melatonin inhibits release of luteinizing hormone via decrease of [Ca2+]i and cyclic AMP. Physiol Res 47:329–335.

    PubMed  CAS  Google Scholar 

  27. Vanecek J. and Klein D.C. 1992 Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells. Endocrinology 130:701–707.

    Article  PubMed  CAS  Google Scholar 

  28. Vanecek J. and Klein D.C. 1992 Sodium-dependent effects of melatonin on membrane potential of neonatal rat pituitary cells. Endocrinology 131:939–946.

    Article  PubMed  CAS  Google Scholar 

  29. Vanecek J. and Klein D.C. 1993 A subpopulation of neonatal gonadotropin-releasing hormone-sensitive pituitary cells is responsive to melatonin. Endocrinology 133:360–367.

    Article  PubMed  CAS  Google Scholar 

  30. Vanecek J. and Vollrath L. 1989 Melatonin inhibits cyclic AMP and cyclic GMP accumulation in the rat pituitary. Brain Res 505:157–159.

    Article  PubMed  CAS  Google Scholar 

  31. Vanecek J. and Vollrath L. 1990 Developmental changes and daily rhythm in melatonin-induced inhibition of 3′,5′-cyclic AMP accumulation in the rat pituitary. Endocrinology 126:1509–1513.

    PubMed  CAS  Google Scholar 

  32. Vanecek J. and Vollrath L. 1990 Melatonin modulates diacylglycerol and arachidonic acid metabolism in the anterior pituitary of immature rats. Neurosci Lett 110199–203.

    Article  PubMed  CAS  Google Scholar 

  33. Vanecek J. and Watanabe K. 1998 Melatonin inhibits increase of cyclic AMP in rat suprachiasmatic neurons induced by vasoactive intestinal peptide. Neurosci Lett 252:21–24.

    Article  PubMed  CAS  Google Scholar 

  34. Watanabe K., Koibuchi N., Ohtake H., and Yamaoka S. 1993 Circadian rhythms of vasopressin release in primary cultures of rat suprachiasmatic nucleus. Brain Res 624:115–120.

    Article  PubMed  CAS  Google Scholar 

  35. Watanabe K., Yamaoka S., and Vanecek J. 1998 Melatonin inhibits spontaneous and VIP-induced vasopressin release from suprachiasmatic neurons. Brain Res 801:216–219.

    Article  PubMed  CAS  Google Scholar 

  36. Weaver D.R., Namboodiri M.A., and Reppert S.M. 1988 Iodinated melatonin mimics melatonin action and reveals discrete binding sites in fetal brain. FEBS Lett 228:123–127.

    Article  PubMed  CAS  Google Scholar 

  37. Williams L.M., Martinoli M.G., Titchener L.T., and Pelletier G. 1991 The ontogeny of central melatonin binding sites in the rat. Endocrinology 128:2083–2090.

    Article  PubMed  CAS  Google Scholar 

  38. Williams L.M. and Morgan P.J. 1988 Demonstration of melatonin-binding sites on the pars tuberalis of the rat. J Endocrinol 119:R1–3.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Vanecek, J., Watanabe, K. (2002). Mechanisms of Melatonin Action in the Pituitary and SCN. In: Olcese, J. (eds) Melatonin After Four Decades. Advances in Experimental Medicine and Biology, vol 460. Springer, Boston, MA. https://doi.org/10.1007/0-306-46814-X_21

Download citation

  • DOI: https://doi.org/10.1007/0-306-46814-X_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46134-7

  • Online ISBN: 978-0-306-46814-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics