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Neuropeptide Y (Npy) and Npy Receptors in The Rat Pineal Gland

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Melatonin After Four Decades

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References

  1. Bowers C.W., Dahm L.M., and Zigmond R.E. The number and distribution of sympathetic neurons that innervate the rat pineal gland. Neuroscience 13:87–96, 1984.

    Article  PubMed  CAS  Google Scholar 

  2. Reiter R.J. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev 12:151–180, 1991.

    Article  PubMed  CAS  Google Scholar 

  3. Lundberg J.M., Terenius L., Hokfelt T., Martling C.R., Tatemoto K., Mutt V., Polak J., Bloom S., and Goldstein M. Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol Scand 116:477–480, 1982.

    PubMed  CAS  Google Scholar 

  4. Schon F., Allen J.M., Yeats J.C., Allen Y.S., Ballesta J., Polak J.M., Kelly J.S., and Bloom S.R. Neuropeptide Y innervation of the rodent pineal gland and cerebral blood vessels. Neurosci Lett 57:65–71, 1985.

    Article  PubMed  CAS  Google Scholar 

  5. Reuss S. and Moore R.Y. Neuropeptide Y-containing neurons in the rat superior cervical ganglion: projections to the pineal gland. J Pineal Res 6:307–316, 1989.

    PubMed  CAS  Google Scholar 

  6. Zhang E.T., Mikkelsen J.D., and Møller M. Tyrosine hydroxylase-and neuropeptide Y-immunoreactive nerve fibers in the pineal complex of untreated rats and rats following removal of the superior cervical ganglia. Cell Tissue Res 265:63–71, 1991.

    Article  PubMed  CAS  Google Scholar 

  7. De Potter W.P., Partoens P., Schoups A., Llona I., and Coen E.P. Noradrenergic neurons release both noradrenaline and neuropeptide Y from a single pool: the large dense cored vesicles. Synapse 25:44–55, 1997.

    PubMed  Google Scholar 

  8. Donoso M.V., Brown N., Carrasco C., Cortes V., Fournier A., and Huidobro-Toro J.P. Stimulation of the sympathetic perimesenteric arterial nerves releases neuropeptide Y potentiating the vasomotor activity of noradrenaline: involvement of neuropeptide Y-Y1 receptors. J Neurochem 69:1048–1059, 1997.

    PubMed  CAS  Google Scholar 

  9. Cozzi B., Mikkelsen J.D., Ravault J.P., and Møller M. Neuropeptide Y (NPY) and C-flanking peptide of NPY in the pineal gland of normal and ganglionectomized sheep. J Comp Neurol 316:238–250, 1992.

    Article  PubMed  CAS  Google Scholar 

  10. Jones M.A. and Marfurt C.F. Peptidergic innervation of the rat cornea. Exp Eye Res 66:421–435, 1998.

    Article  PubMed  CAS  Google Scholar 

  11. Blomqvist A.G. and Herzog H. Y-receptor subtypes—how many more? Trends Neurosci 20:294–298, 1997.

    Article  PubMed  CAS  Google Scholar 

  12. Herzog H., Hort Y.J., Ball H.J., Hayes G., Shine J., and Selbie L.A. Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc Natl Acad Sci USA 89:5794–5798, 1992.

    PubMed  CAS  Google Scholar 

  13. Larsen P.J., Sheikh S.P., Jakobsen C.R., Schwartz T.W., and Mikkelsen J.D. Regional distribution of putative NPY Y1 receptors and neurons expression Y1 mRNA in forebrain areas of the rat central nervous system. Eur J Neurosci 5:1622–1637, 1993.

    PubMed  CAS  Google Scholar 

  14. Larsen P.J. and Kristensen P. The neuropeptide Y (Y4) receptor is highly expressed in neurons of the rat dorsal vagal complex. Molecular Brain Research 48:1–6, 1997.

    Article  PubMed  CAS  Google Scholar 

  15. Gustafson E.L., Smith K.E., Durkin M.M., Walker M.W., Gerald C., Weinshank R., and Branchek T.A. Distribution of the neuropeptide Y Y2 receptor mRNA in rat central nervous system. Brain Res Mol Brain Res 46:223–235, 1997.

    PubMed  CAS  Google Scholar 

  16. Dumont Y., Fournier A., and Quirion R. Expression and characterization of the neuropeptide Y Y5 receptor subtype in the rat brain. J Neurosci 18:5565–5574, 1998.

    PubMed  CAS  Google Scholar 

  17. Wahlestedt C., Yanaihara N., and Håkanson R. Evidence for different pre-and post-junctional receptors for neuropeptide Y and related peptides. Regul Pept 13:307–318, 1986.

    Article  PubMed  CAS  Google Scholar 

  18. Olcese J. Neuropeptide Y: an endogenous inhibitor of norepinephrine-stimulated melatonin secretion in the rat pineal gland. J Neurochem 57:943–947, 1991.

    PubMed  CAS  Google Scholar 

  19. Simonneaux V., Ouichou A., Craft C., and Pevet P. Presynaptic and postsynaptic effects of neuropeptide Y in the rat pineal gland. J Neurochem 62:2464–2471, 1994.

    PubMed  CAS  Google Scholar 

  20. Vacas M.I., Sarmiento M.I., Pereyra E.N., Etchegoyen G.S., and Cardinali D.P. In vitro effect of neuropeptide Y on melatonin and norepinephrine release in rat pineal gland. Cell Mol Neurobiol 7:309–315, 1987.

    Article  PubMed  CAS  Google Scholar 

  21. O’Hare M.M. and Schwartz T.W. Expression and precursor processing of neuropeptide Y in human and murine neuroblastoma and pheochromocytoma cell lines. Cancer Res 49:7015–7019, 1989.

    Google Scholar 

  22. Mikkelsen J.D., Larsen P.J., O’Hare M.M., and Wiegand S.J. Gastrin releasing peptide in the rat suprachiasmatic nucleus: an immunohistochemical, chromatographic and radioimmunological study. Neuroscience 405–546, 1991.

    Google Scholar 

  23. Blinkenberg M., Kruse-Larsen C., and Mikkelsen J.D. An immunohistochemical localization of neuropeptide Y (NPY) in its amidated form in human frontal cortex. Peptides 11:129–137, 1990.

    Article  PubMed  CAS  Google Scholar 

  24. Mikkelsen J.D. and Møller M. A direct neural projection from the intergeniculate leaflet of the lateral geniculate nucleus to the deep pineal gland of the rat, demonstrated with Phaseolus vulgaris leucoagglutinin. Brain Res 520:342–346, 1990.

    Article  PubMed  CAS  Google Scholar 

  25. Jessop D.S., Larsen P.J., Mikkelsen J.D., Lightman S.L., and Chowdrey H.S. Effects of adrenalectomy and hypertonic saline on neuropeptide Y content in the posterior pituitary of the rat. Neuroendocrinology 57:416–421, 1993.

    PubMed  CAS  Google Scholar 

  26. Greisen M.H., Sheikh S.P., Bolwig T.G., and Mikkelsen J.D. Reduction of neuropeptide Y binding sites in the rat hippocampus after electroconvulsive stimulations. Brain Res 776:105–110, 1997.

    Article  PubMed  CAS  Google Scholar 

  27. Larsen P.J., Enquist L.W., and Card J.P. Characterization of the multisynaptic neuronal control of the rat pineal gland using viral transneuronal tracing. Eur J Neurosci 10:128–145, 1998.

    Article  PubMed  CAS  Google Scholar 

  28. Mikkelsen J.D. and Mick G. Neuropeptide Y (NPY)-immunoreactive nerve fibers in the pineal gland of the macaque (Macaca fascicularis). J Neuroendocrinol 4:681–688, 1992.

    Google Scholar 

  29. Shiotani Y., Yamano M., Shiosaka S., Emson P.C., Hillyard C.J., Girgis S., and MacIntyre I. Distribution and origins of substance P (SP)-, calcitonin gene-related peptide (CGRP)-, vasoactive intestinal polypeptide (VIP)-and neuropeptide Y (NPY)-containing nerve fibers in the pineal gland of gerbils. Neurosci Lett 70:187–192, 1986.

    Article  PubMed  CAS  Google Scholar 

  30. Landis S.C., Jackson P.C., Fredieu J.R., and Thibault J. Catecholaminergic properties of cholinergic neurons and synapses in adult rat ciliary ganglion. J Neurosci 7:3574–3587, 1987.

    PubMed  CAS  Google Scholar 

  31. Gibbins I.L. and Morris J.L. Co-existence of immunoreactivity to neuropeptide Y and vasoactive intestinal peptide in non-noradrenergic axons innervating guinea pig cerebral arteries after sympathectomy. Brain Res 444:402–406, 1988.

    Article  PubMed  CAS  Google Scholar 

  32. Sawchenko P.E., Swanson L.W., Grzanna R., Howe P.R., Bloom S.R., and Polak J.M. Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus. J Comp Neurol 241:138–153, 1985.

    Article  PubMed  CAS  Google Scholar 

  33. Harrington M.E., Nance D.M., and Rusak B. Double-labeling of neuropeptide Y-immunoreactive neurons which project from the geniculate to the suprachiasmatic nuclei. Brain Res 410:275–282, 1987.

    Article  PubMed  CAS  Google Scholar 

  34. Harrington M.E., Nance D.M., and Rusak B. Neuropeptide Y immunoreactivity in the hamster genicula-suprachiasmatic tract. Brain Res Bull 15:465–472, 1985.

    Article  PubMed  Google Scholar 

  35. Card J.P. and Moore R.Y. Organisation of lateral geniculate-hypothalamic connections in the rat. J Comp Neurol 284:135–147, 1989.

    Article  PubMed  CAS  Google Scholar 

  36. Mikkelsen J.D. Projections from the lateral geniculate nucleus to the hypothalamus of the Mongolian gerbil (Meriones unguiculatus): an anterograde and retrograde tracing study. J Comp Neurol 299:493–508, 1990.

    Article  PubMed  CAS  Google Scholar 

  37. Albers H.E. and Ferris C.F. Neuropeptide Y: role in light-dark cycle entrainment of hamster circadian rhythms. Neurosci Lett 50:163–168, 1984.

    Article  PubMed  CAS  Google Scholar 

  38. Rusak B., Meijer J.H., and Harrington M.E. Hamster circadian rhythms are phase-shifted by electrical stimulation of the geniculo-hypothalamic tract. Brain Res 493:283–291, 1989.

    Article  PubMed  CAS  Google Scholar 

  39. Whitcomb D.C., Taylor I.L., and Vigna S.R. Characterization of saturable binding sites for circulating pancreatic polypeptide in rat brain. Am J Physiol 259:G687–691, 1990.

    PubMed  CAS  Google Scholar 

  40. Harada Y., Okubo M., Yaga K., Kaneko T., and Kaku K. Neuropeptide Y inhibits beta-adrenergic agonist-and vasoactive intestinal peptide-induced cyclic AMP accumulation in rat pinealocytes through pertussis toxin-sensitive G protein. J Neurochem 59:2178–2183, 1992.

    PubMed  CAS  Google Scholar 

  41. Fried G., Terenius L., Hokfelt T., and Goldstein M. Evidence for differential localization of noradrenaline and neuropeptide Y in neuronal storage vesicles isolated from rat vas deferens. J Neurosci 5:450–458, 1985.

    PubMed  CAS  Google Scholar 

  42. Malpas S.C. The rhythmicity of sympathetic nerve activity [In Process Citation]. Prog Neurobiol 56:65–96, 1998.

    Article  PubMed  CAS  Google Scholar 

  43. Edvinsson L., Ekblad E., Håkanson R., and Wahlestedt C. Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels. Br J Pharmacol 83:519–525, 1984.

    PubMed  CAS  Google Scholar 

  44. Nilsson S.F. Neuropeptide Y (NPY): a vasoconstrictor in the eye, brain and other tissues in the rabbit. Acta Physiol Scand 141:455–467, 1991.

    Article  PubMed  CAS  Google Scholar 

  45. Håkanson R., Wahlestedt C., Ekblad E., Edvinsson L., and Sundler F. Neuropeptide Y: coexistence with noradrenaline. Functional implications. Prog Brain Res 68:279–87:279–287, 1986.

    PubMed  Google Scholar 

  46. Potter E.K., Mitchell L., McCloskey M.J., Tseng A., Goodman A.E., Shine J., and McCloskey D.I. Pre-and postjunctional actions of neuropeptide Y and related peptides. Regul Pept 25:167–177, 1989.

    Article  PubMed  CAS  Google Scholar 

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Mikkelsen, J.D., Hauser, F., Olcese, J. (2002). Neuropeptide Y (Npy) and Npy Receptors in The Rat Pineal Gland. In: Olcese, J. (eds) Melatonin After Four Decades. Advances in Experimental Medicine and Biology, vol 460. Springer, Boston, MA. https://doi.org/10.1007/0-306-46814-X_13

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  • DOI: https://doi.org/10.1007/0-306-46814-X_13

  • Publisher Name: Springer, Boston, MA

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