Collection
Special Issue 2023: Immunogenetics of Infectious Disease
In this Special Issue, particular emphasis is placed on human or primate models in research involving infectious disease. The selection of reviews and original articles will include the immunogenetics of COVID-19 severity, herpes virus co-evolution with HLA, TAP dependency in the response to infection, quantifying HLA expression for disease studies, diversity of glycophorins and KIR/HLA in the response to malaria, immunogenetics of tuberculosis in Southern Africa, and new models for predicting the strength of genetically driven immunity.
Paul J. Norman’s main area of interest is the genetics of human immunity. He studies natural variation in immune responses that evolved as modern human populations expanded and adapted to new environments. His particular focus is co-evolution of the HLA markers for healthy cells and the Natural Killer cell receptors that bind them. Paul has studied African and Amerindian hunter-gatherers, Maoris, and indigenous Australians, and analysed the genomes of ancient humans to trace their immune legacy in present-day populations. He devised the first high-throughput methods to sequence entire MHC and KIR genomic regions. The methods are being used to investigate, among other things, the immunogenetic diversity of infectious and neurological disease, preeclampsia, and leukemia.
Dr. Norman worked with Peter Parham at Stanford for 16 years before setting up his lab at the University of Colorado in 2018, where he currently leads a team of three postdocs and five graduate students.
Norman LabEditors
-
Paul J. Norman
University of Colorado
Anschutz Medical Campus, School of Medicine, Division of Biomedical Informatics & Personalized Medicine, Aurora, CO 80045, USA
Articles (6 in this collection)
-
-
-
-
-
Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans
Authors (first, second and last of 4)
-
