Collection

Advances in Microbial Nanofactories for Biomedical application

Submission status
Closed
Bionanomaterials have recently gained attention in biology, medicine, engineering, and agriculture. Due to its peculiar features as a material, viz., large surface to volume ratio, shape, size, and dimensions, it is ideal for biotechnological applications and biomedicine in particular. The constraints of physicochemical approaches to prepare nanoparticles could be addressed by biological methods. Biogenic nanoparticles have proven to be an efficient, reliable, safe, sustainable, and eco-friendly method. Microbial entities such as bacteria, algae, fungi, and yeasts synthesize the nanomaterials in the form of Quantum Dots, Clusters, Nanoparticles, and composites. Viruses have also been demonstrated as nanocarriers. It is believed that the active molecules released by the microbes act as capping agents to overcome the aggregation and eventually increase the stability. Microorganisms are cell factories that produce a variety of bioactive molecules such as metabolites, sugars, proteins, and peptides, as well as pigments that act as capping and/or reducing agents in the synthesis of organic and inorganic metallic and polymeric nanoparticles for mitigation of various pathogenic infections including, bacterial, fungal and viral and chronic diseases (cancer, diabetes, arthritis, etc.). Therefore, understanding the undelaying molecular mechanism of microbial nanoparticles' production relationship with isolation sources can assist in establishing the standard techniques for large-scale production. On the other hand, although the natural products of the microbes exhibit promising therapeutic effects in the in vitro system, the potential property is poor in in vitro due to high adverse effects, less stability, and inefficiency in targeting the pathological site. From the innovations in nanoscience and materials chemistry, the development of nano-drug delivery systems can improve the therapeutic effect of microbial molecules. Also, microbes are prime cell factories for biopolymers, which are exclusively used for the development of medical applications, particularly in the development of polymeric nanodrugs. For example, the fungal cell wall is a source for the production of chitosan while the bacteria convert the carbon and nitrogen sources into biopolymers for industrial and medical applications. Currently, microbial nanoparticles are widely utilized in biomedical applications in biosensors, imaging, diagnostics, nanodrugs, regenerative medicine, and antimicrobials. However, the detailed methods and optimization strategies of biogenic nanoparticles and biopolymers production and their high throughput characterization techniques are not yet well explored for large scale-up. Hence, this thematic special issue aims to uncover the fundamental mechanisms of microbial nano factories for the production of nanoparticles, natural products, biopolymers, and surfactants for the development of bionanomaterials for diagnostics and therapeutics. The submissions represented in this special issue will include full-length research and review articles. Topics included (but not limited to) 1. Microbial cell factories for nanoparticles and nano biopolymer production 2. Development of nDDS for enhanced therapeutic effects of microbial-derived molecules 3. Convergence of microbiology, nanoscience, and materials chemistry for biomedical applications 4. Methods for the characterization of nDDS, biogenic organic and inorganic nanoparticles. 5. Analysis of microbial pathways involved in biomaterials production through transcriptomics, proteomics, and metabolomics 6. Advances in synthetic and biogenic antimicrobial and antiviral nanomaterials.

Editors

  • Dr. Kandasamy Saravanakumar Dr. Kandasamy Saravanakumar  &

    Dr. Kandasamy Saravanakumar

    Dr. Kandasamy Saravanakumar is working as a Research Professor at Kangwon National University in the Republic of Korea. He has received a doctoral degree from Annamalai University, India, and has over ten years of research experience in Fungi Biology including Fungal production of therapeutic nanoparticles, Molecular Biology, Plant Pathology, Plant-Microbe Interactions, Cancer Biology with special reference to disease diagnosis and therapeutics, natural product biomaterials, anticancer activities, and drug delivery systems. He has published more than 150 scientific papers in reputed international journals.

  • Dr. Davoodbasha MubarakAli Dr. Davoodbasha MubarakAli

    Dr. Davoodbasha MubarakAli

    Dr. Davoodbasha MubarakAli is currently working as an Assistant Professor at the B. S. Abdur Rahman Crescent Institute of Science and Technology, Chennai, India. He has received a Ph. D in Microbiology from Bharathidasan University, India. He has been published more than 100 papers, including review, research, and book chapters, corresponding to fields of Microbial Biotechnology, Microbial Value-Added Products, Nanobiomaterials, Microbial Synthesis of Nanoparticles, Biomass, and Bioenergy. He has been currently serving as an Editorial member for several international reputed journals.

Articles (32 in this collection)