Comparison of analgesic efficacy of ibuprofen and dexketoprofen in pain management of long bone fractures: a prospective, randomized, double-blind study
Authors (first, second and last of 6)
Collection
Bone Defect Treatment
Time and again, traumatologists and orthopedic surgeons have to deal with the issue of bone defects. Whether after major trauma, tumor resection or, for example, septic pseudarthrosis. The treatment is always a long-term treatment and due to the recurrent interventions unfortunately always associated with relatively high complication rates and high costs.
Defects of a size of 4-5cm can usually be filled with autologous bone graft, heterologous bone from cadavers, or artificial bone graft substitutes. Defects larger than 5cm require either vascularized free bone transfer, the Induced Membrane (Masquelet-) Technique or Ilizarov distraction osteogenesis.
In recent years, some additional new options have entered the treatment of bone defects. The use of autologous cell transplantation, either after expansion in culture ex vivo or without expansion in culture or the use of new materials or cell-material combinations from the 3D printer.
In this collection I would like to give you an overview of the current treatment options, but also of possible future treatment methods.
I hope that reading the articles belonging to this collection will give you an insight and help you to find the right treatment for your patient.
Editors
-
René D. Verboket
René D. Verboket is a senior physician at the Department of Trauma, Hand and Reconstructive Surgery at Frankfurt University Hospital. His research focus is on the regeneration of long-distance bone defects with Prof. Marzi and Prof. Henrich. Especially the field of translational research in relation to cell therapies is one of his specialties.
Articles (21 in this collection)
-
-
Treatment of tibial bone defects: pilot analysis of direct medical costs between distraction osteogenesis with an Ilizarov frame and the Masquelet technique
Authors (first, second and last of 6)
-
Bone defect treatment: does the type and properties of the spacer affect the induction of Masquelet membrane? Evidence today
Authors (first, second and last of 5)
-
Autoclave sterilization of an in-house 3D-printed polylactic acid piece: biological safety and heat-induced deformation
Authors (first, second and last of 7)
-
Induced membrane technique: a critical literature analysis and proposal for a failure classification scheme
Authors (first, second and last of 6)
-
Impact of scaffold granule size use in Masquelet technique on periosteal reaction: a study in rat femur critical size bone defect model
Authors (first, second and last of 8)
-
Determination of the effective dose of bone marrow mononuclear cell therapy for bone healing in vivo
Authors (first, second and last of 11)
-
-
From two stages to one: acceleration of the induced membrane (Masquelet) technique using human acellular dermis for the treatment of non-infectious large bone defects
Authors (first, second and last of 13)
-
‘Acute Masquelet technique’ for reconstructing bone defects of an open lower limb fracture
Authors (first, second and last of 8)
-
3D printing of implants for patient-specific acetabular fracture fixation: an experimental study
Authors (first, second and last of 4)
-
Masquelet technique for open tibia fractures in a military setting
Authors (first, second and last of 7)
-
Induced membrane maintains its osteogenic properties even when the second stage of Masquelet’s technique is performed later
Authors (first, second and last of 12)
-
Effect of bone sialoprotein coating on progression of bone formation in a femoral defect model in rats
Authors (first, second and last of 10)
-
Cultivation of EPC and co-cultivation with MSC on β-TCP granules in vitro is feasible without fibronectin coating but influenced by scaffolds’ design
Authors (first, second and last of 9)
-
Autologous cell-based therapy for treatment of large bone defects: from bench to bedside
Authors (first, second and last of 9)
-
Reamer–Irrigator–Aspirator bone graft harvesting for treatment of segmental bone loss: analysis of defect volume as independent risk factor for failure
Authors (first, second and last of 6)
-
Reconstruction of post-traumatic long segment bone defects of the lower end of the femur by free vascularized fibula combined with allograft (modified Capanna’s technique)
Authors (first, second and last of 5)
-
Mesenchymal stem cell (MSC) and endothelial progenitor cell (EPC) growth and adhesion in six different bone graft substitutes
Authors (first, second and last of 6)
-
-
Bone Substitution and Augmentation in Trauma Surgery with a Resorbable Calcium Phosphate Bone Cement
Authors (first, second and last of 6)
