Melt Crystallization of Celecoxib-Carbamazepine Cocrystals with the Synchronized Release of Drugs
Authors (first, second and last of 5)
Collection
Pharmaceutical Particle and Crystal Engineering
Particles and crystals play an essential role in pharmaceutical manufacturing. Successful manufacturing and quality of finished pharmaceutical products critically depend on powder properties, such as flowability, tabletability, wettability, solubility, and stability. These powder properties, in turn, are controlled by the properties of constituting particles or crystals of active pharmaceutical ingredients (API) and excipients, such as size, size distribution, shape, porosity, mechanical properties, surface energy, and surface roughness. Hence, appropriate engineering of particles through various processes, such as crystallization, granulation (dry, wet, fluid bed), hot-melt extrusion, spray-drying, and dry coating, is effective in overcoming problems in pharmaceutical manufacturing. Thus, engineering pharmaceutical materials at particle level helps solve many problems in pharmaceutical manufacturing. This themed issue is intended to capture the cutting-edge research in this direction to highlight the importance of particle and crystal engineering in pharmaceutical research.
Editors
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Calvin Sun
Changquan Calvin Sun, PhD, is a Professor and Associate Department Head, Department of Pharmaceutics, at University of Minnesota College of Pharmacy. Dr. Sun's research focuses on manufacturing science of solid dosage forms, such as tablets and capsules. Formulation and process development is achieved by a clear scientific understanding of powders, including their flow and compaction properties. In this way, design replaces trial and error, and improved quality results.
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Rajesh (Raj) Dave
Dr. Davé is the founding Director of the R&D Excellence Center, New Jersey Center for Engineered Particulates, focusing on research and innovations in particle engineering for improved particle properties for applications to pharmaceutical, food, electronics, and energy industries. Under his direction, the center has developed into an important resource for researchers and industry alike in the areas of nanoparticles and nanocomposites.
Articles (14 in this collection)
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Improving the Manufacturability of Cohesive and Poorly Compactable API for Direct Compression of Mini-tablets at High Drug Loading via Particle Engineering
Authors (first, second and last of 5)
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Densifying Co-Precipitated Amorphous Dispersions to Achieve Improved Bulk Powder Properties
Authors (first, second and last of 6)
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Breakage Assessment of Lath-Like Crystals in a Novel Laboratory-Scale Agitated Filter Bed Dryer
Authors (first, second and last of 7)
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Advancements in Particle Engineering for Inhalation Delivery of Small Molecules and Biotherapeutics
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Application of Twin-Screw Melt Granulation to Overcome the Poor Tabletability of a High Dose Drug
Authors (first, second and last of 8)
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Reduced Fine API Agglomeration After Dry Coating for Enhanced Blend Uniformity and Processability of Low Drug Loaded Blends
Authors (first, second and last of 4)
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Prediction of the Mechanical Deformation Properties of Organic Crystals Based upon their Crystallographic Structures: Case Studies of Pentaerythritol and Pentaerythritol Tetranitrate
Authors (first, second and last of 4)
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Assessing the Interrelationship of Microstructure, Properties, Drug Release Performance, and Preparation Process for Amorphous Solid Dispersions Via Noninvasive Imaging Analytics and Material Characterization
Authors (first, second and last of 11)
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