Collection

Special Issue: Impact of life style und behavioral risk factors on endothelial function and vascular biology

Submission status
Closed

There is increasing evidence that lifestyle and behavioral risk factors in the environment such as smoking and sedentary lifestyle may facilitate the development of chronic non-communicable disease of cardiometabolic origin. Tobacco smoking is a major trigger of chronic non-communicable disease and a risk factor for cardiovascular and lung disease. Whereas global tobacco use was reduced during the last two decades, mostly due to a reduction of female smokers, the use of E-cigarettes, novel nicotine delivery systems such as heat-not-burn products and waterpipes (shisha) shows a pandemic growth, especially due to flavoring of tobaccos and liquids, a lower starting age of users, facilitated usage or higher nicotine content causing faster addiction. Likewise, alcohol abuse is another lifestyle drug dependent cardiovascular health issue. Western societies and emerging market countries also face an increasing rate of people with sedentary lifestyle or over-nutrition, risk factors that are well-known to trigger cardiometabolic disease by impairment of beneficial vascular function. The present special issue provides an overview on health effects of tobacco cigarette and shisha smoking, E-cigarette vaping, usage of other novel nicotine delivery systems, sedentary lifestyle or over-nutrition with focus on negative effects on endothelial function and cardiovascular health. The adverse effects of the toxic constituents of these tobacco (replacement) products as well as the beneficial effects of exercise or fasting on different biological pathways will be discussed, especially regarding their impact on key vascular processes such as nitric oxide signaling, smooth muscle proliferation, remodeling, atherosclerosis, in part driven by oxidative stress and inflammatory cascades. With the present Special Issue we want to highlight the pathomechanisms underlying cardiovascular and metabolic disorders in response to environmental risk factors and the existing research gaps. We will also emphasize emerging mechanisms based on dysregulation of the circadian clock, the microbiome and epigenetic pathways by environmental lifestyle and behavioral risk factors.

Invited papers. Open submissions are also welcome.

Editors

  • Andreas Daiber Andreas Daiber , 

    Andreas Daiber

    Center for Cardiology 1 University Medical Center Mainz, Germany

  • Omar Hahad Omar Hahad  &

    Omar Hahad

    Center for Cardiology 1 University Medical Center Mainz, Germany

  • Thomas Münzel Thomas Münzel

    Thomas Münzel

    Center for Cardiology 1 University Medical Center Mainz, Germany

Articles (12 in this collection)