Collection

Cancer Metabolism: A Therapeutic Perspective

Submission status
Closed
Metabolism is referred to as the biochemical processes that occur within living organisms in order to maintain life, which is a key character that distinguishes a living thing from a non-living thing. In comparison with most normal tissue cells, cancer cells possess unique metabolic features, such as aerobic glycolysis, reduced oxidative phosphorylation, and increased biosynthesis of metabolite intermediates required for cell growth and proliferation. These unique metabolic characteristics of cancer cells lead to novel signaling transduction pathways and physiological states (such as low pH caused by accumulated lactate) of the tumor microenvironment. The studies of cancer metabolism not only facilitate the understandings of the genetic and biochemical basis of cancer development, but provide new perspectives for cancer therapies by targeting metabolic regulatory pathways. In this Topical Collection, we aim to give a broad survey of the most recent advances in cancer metabolism and relevant therapeutic strategies. Research Articles, Reviews, Perspectives, Comments, Brief Communications, Case Reports, Case Studies, Clinical Trials, Registered Reports, and Data Notes that discuss both basic and translational research of cancer metabolism with a therapeutic perspective are welcome.

Keywords: Cancer Metabolism; Metabolic Pathway; Oncogenetic Metabolite; Tumor Microenvironment; Oncogenic Signaling; Cancer Therapy

Editors

  • Qingfei Zheng Qingfei Zheng

    Qingfei Zheng

    Assistant Professor Qingfei Zheng, The Ohio State University, USA He is an Assistant Professor in the Department of Radiation Oncology and Center for Cancer Metabolism at The Ohio State University (OSU). He aspires to tackle chemical and biological problems by simultaneously developing new chemical tools to study complex biological mechanisms and engineering novel biological systems to produce synthetically inaccessible chemicals. Currently, his lab is trying to apply chemical and synthetic biology approaches towards studying cancer metabolism, epigenetics, and tumor microbiome for the development of new personalized cancer therapies.

Articles (10 in this collection)