Cyrene: a very reactive bio-based chiral ketone in diastereoselective Passerini reactions
Authors (first, second and last of 6)
Collection
100 years of isocyanide-based multicomponent reactions
2021 was the centennial of the discovery of Passerini reaction , the first isocyanide-based multicomponent reaction to be reported in the literature. Therefore 2021 can be considered the anniversary of all isocyanide-based multicomponent reactions (IMCRs). On this occasion, Molecular Diversity intends to publish a special issue dedicated to isocyanide-based multicomponent reactions and their applications.
Over the years this field has increasingly grown, expanding in various directions: a) new IMCRs have been discovered; b) new variants of the known IMCRs, by changing one of the components, have been developed; c) new scaffolds have been obtained by post-MCR transformations; d) new conditions (unusual solvents, catalysts) have been explored explored; e) new solutions of stereochemical problems have been proposed. Last but not least, IMCR are more and more applied in various fields, from the most traditional one (drug discovery), to others that have become increasingly important in recent years, such as: polymer chemistry, material synthesis, target-oriented synthesis of APIs or natural substances.
Editors
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Chiara Lambruschini, PhD, University of Genoa, Italy
Chiara Lambruschini is an Assistant Professor in the Department of Chemistry and Industrial Chemistry at the University of Genoa, Italy
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Luca Banfi, MS, University of Genoa, Italy
Luca Banfi is a Professor at the University of Genoa, Italy. He is the director of the Department of Chemistry and Industrial Chemistry
Articles (13 in this collection)
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Ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate in the smiles rearrangement reaction: straightforward synthesis of amino acid derived quinolin-2(1H)-one enamines
Authors (first, second and last of 6)
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Curation and cheminformatics analysis of a Ugi-reaction derived library (URDL) of synthetically tractable small molecules for virtual screening application
Authors (first, second and last of 5)
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Enantiopure β-isocyano-boronic esters: synthesis and exploitation in isocyanide-based multicomponent reactions
Authors (first, second and last of 5)
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Application of the Ugi reaction for preparation of submicron capsules based on sugar beet pectin
Authors (first, second and last of 5)
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New oxacycles on the block: benzodioxepinones via a Passerini reaction
Authors (first, second and last of 4)
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A synthesis of functionalized 3-amino-1,2,4-triazoles from nitrile imines and guanidine derivatives
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Synthesis of fused polycyclic β-carboline derivatives using Ugi-4CR followed by cascade cyclization
Authors (first, second and last of 6)
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Domino synthesis of 5-aminoimidazoles from Strecker multicomponent adducts via ytterbium-promoted isocyanide insertion/5-exo-dig cyclization
Authors (first, second and last of 8)
