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Application of Ultrasonography for in vivo diagnosis of fatty liver disease in mink (Neovison vison)

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Abstract

High abundance of fat stored within the liver, referred to as fatty liver disease (FLD) is frequently associated with mortalities in mink during the growth period. Studies have indicated that increased tendency for development of FLD may be one of the consequences of reduced protein contents in mink food. For studies on FLD in mink, quantitative analysis of hepatic fat in live mink using ultrasonography would be an appealing non-invasive study modality. The objective of this study was to develop and evaluate a technique for quantifying hepatic fat content in mink by ultrasonography, applying techniques previously validated for use in humans and cats. This study shows that infiltration of the mink liver with fat may be evaluated non-invasively using ultrasonography. This diagnostic imaging technique may prove useful for research in diffuse parenchymal organ disease in mink, though local hair removal prior to application of ultrasonography of organs is a considerable disadvantage in some settings.

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References

  • Bedogni, G., Bellentani, S., Miglioli, L., Masutti, F., Passalacqua, M., Castiglione, A.and Tiribelli C. 2006. The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol. 6: 33.

    Article  PubMed  Google Scholar 

  • Biller, D.S., Kantrowitz, B. and Miyabayashi, T., 1992. Ultrasonography of diffuse liver disease. A review. J Vet Intern Med. 6: 71–76.

    Article  CAS  Google Scholar 

  • Clausen, T.N. and Sandbøl, P., 2005. Fasting of mink kits feed different feed rations and its effect on liver fat content, plasma metabolites and enzymes. NJF seminar nr 337, pp. 5, Uppsala, Oct. 5–7.

    Google Scholar 

  • Clausen, T, 2006. Hvad dør mink af genem et produktionsår (In Danish). In: Møller, S.H. (ed.), Store mink — store udfordringer. Produktion af højtydende mink uden uønskede følgevirkninger, Intern Rapport, Husdyrbrug nr. 2. Danmarks Jordbrugsforskning, Tjele, Denmark, pp. 68–71.

    Google Scholar 

  • Clausen, T.N., 2010. Kit death from birth to August the first (In Danish) Dødsårsager fra fødsel til 1. august. In: Sandbøl, P. (ed.), Annual Report 2009, Danish Fur Breeders Research Center.

    Google Scholar 

  • Damgaard, B.M., Clausen, T.N. and Henriksen, P., 1994. Effect of protein and fat content in feed on plasma alanine aminotransferase and hepatic liver infiltration in mink. J. Vet. Med. A. 41: 620–629.

    Article  CAS  Google Scholar 

  • Damgaard, B.M., Clausen, T.N. and Dietz, H.H., 1998a. Effect of dietary protein level on growth performance, mortality rate and clinical blood parameters in mink (Mustela vison). Acta Agric. Scand., Sect. A, Animal Sci. 48: 38–48.

    CAS  Google Scholar 

  • Damgaard, B.M., Clausen, T.N. and Børsting, C.F., 1998b. Effect of dietary supplement of essential amino acids on mortality rate, liver traits and blood parameters in mink (Mustela vison) fed low-protein diets. Acta Agric. Scand., Sect. A, Animal Sci. 48: 175–183.

    CAS  Google Scholar 

  • De Lima, V.M., Oliveira, C.P., Alves, V.A., Chammas, M.C., Oliveira, E.P., Stefano, J.T., de Mello, E.S., Cerri, G.G., Carrilho, F.J. and Caldwell, S.H., 2008. A rodent model of NASH with cirrhosis, oval cell proliferation and hepatocellular carcinoma. J Hepatol. 49: 1055–1061.

    Article  PubMed  Google Scholar 

  • Dick, R., 1998. The liver and spleen In: Textbook of radiology imaging. Chapter 6. Sutton D. (ed.). China: Churchill Livingstone, pp. 981–1028.

    Google Scholar 

  • Dias, J.V., Paredes, B.D., Mesquita, L.F., Carvalho, A.B., Kozlowski, E.O., Lessa, A.S., Takiya, C.M., Resende, C.M., Coelho, H.S., Campos-de-Carvalho, A.C., Rezende, G.F. and Goldenberg, R.C., 2008. An ultrasound and histomorphological analysis of experimental liver cirrhosis in rats. Braz J Med Biol Res. 41: 992–999.

    Article  PubMed  CAS  Google Scholar 

  • England, G.C.W.,1996. Renal and hepatic ultrasonography in the neonatal dog. Vet Radiol Ultrasound. 37: 374–382.

    Article  Google Scholar 

  • Feeney, DA, Anderson KL, Ziegler LE, Jessen CR, Daubs BM and Hardy RM., 2008. Statistical relevance of ultrasonographic criteria in the assessment of diffuse liver disease in dogs and cats. Am J Vet Res. 69: 212–221.

    Article  PubMed  Google Scholar 

  • Lamb, C.R., 1990. Abdominal ultrasonography in small animals: examination of the liver, spleen and pancreas. J Small Anim Pract. 31: 5–8.

    Article  Google Scholar 

  • Lessa, A.S., Paredes, B.D., Dias, J.V., Carvalho, A.B., Quintanilha, L.F., Takiya, C.M., Tura, B.R., Rezende, G.F., Campos de Carvalho, A.C., Resende, C.M. and Goldenberg, R.C., 2010. Ultrasound imaging in an experimental model of fatty liver disease and cirrhosis in rats. BMC Vet Res. 29: 6.

    Article  Google Scholar 

  • Mwanza, T., Miyamoto, T., Okumura, M., Kadosawa, T. and Fujinaga, T., 1997. Ultrasonography, biochemical and hematological profiles in liver disease caused by intravenous administration of dimethylnitrosamine in dogs. Jpn J Vet Res. 45: 153–161.

    PubMed  CAS  Google Scholar 

  • Nicoll, R.G., Jackson, M.W., Knipp, B.S., Zagzebski, J.A., Steinberg, H. and O’Brien, R.T., 1998. Quantitative ultrasonography of the liver in cats during obesity induction and dietary restriction. Res Vet Sci. 64(1): 1–6.

    Article  PubMed  CAS  Google Scholar 

  • Partington, B.P. and Biller, D.S., 1995. Hepatic imaging with radiology and ultrasound. Vet Clin North Am Small Anim Pract. 25: 305–335.

    PubMed  CAS  Google Scholar 

  • Schalm, SW., 1997. The diagnosis of cirrhosis: clinical relevance and methodology. J Hepatol. 27: 1118–1119.

    Article  PubMed  CAS  Google Scholar 

  • Yeager, A.E. and Mohammed, H., 1992. Accuracy of ultrasonography in the detection of severe hepatic lipidosis in cats. Am J Vet Res. 53: 597–599.

    PubMed  CAS  Google Scholar 

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Correspondence to A. S. Hammer .

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P. F. Larsen S. H. Møller T. Clausen A. S. Hammer T. M. Lássen V. H. Nielsen A. H. Tauson L. L. Jeppesen S. W. Hansen J. Elnif J. Malmkvist

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© 2012 Wageningen Academic Publishers The Netherlands

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Hammer, A.S., Clausen, T. (2012). Application of Ultrasonography for in vivo diagnosis of fatty liver disease in mink (Neovison vison). In: Larsen, P.F., et al. Proceedings of the Xth International Scientific Congress in fur animal production. Wageningen Academic Publishers, Wageningen. https://doi.org/10.3920/978-90-8686-760-8_28

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