Abstract
Tularemia (rabbit fever) is a serious infectious disease caused by Francisella tularensis infecting human and farm animals including cattle, rabbits, horses and sheep. The disease is economically important in rabbit industry. It is already known that Francisella readily adhere to various cells like macrophages, epithelial cells, endothelial cells, etc. to evoke self internalization or crossing of various cell barriers [1–3]. There is still a lack of data that reveals interactions between pathogen ligands and host receptors expressed on the endothelial cells, which are crucial in initial steps of infection. In our previous study we showed that ICAM-1 is the most probable adhesive molecule for Francisella on endothelial cells (EC). The objective of this study was to identify protein candidate(s) from Francisella interacting with ICAM-1.
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References
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Acknowledgements
We thank Dr. E.B. Chakurkar from Indian Council of Agricultural Research (ICAR) Complex (India) for his the excellent assistance in preparation of recombinant form of proteins. The work was supported by APVV-0036-10 and VEGA- 2/0121/11.
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Mucha, R. et al. (2012). Adhesion of Francisella to endothelial cells is also mediated by OmpA:ICAM-1 interaction. In: Rodrigues, P., Eckersall, D., de Almeida, A. (eds) Farm animal proteomics. Wageningen Academic Publishers. https://doi.org/10.3920/978-90-8686-751-6_22
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DOI: https://doi.org/10.3920/978-90-8686-751-6_22
Publisher Name: Wageningen Academic Publishers
Online ISBN: 978-90-8686-751-6
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