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The Biology of HDAC8, a Unique Class I Histone Deacetylase

  • Chapter
Histone Deacetylases

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

HDAC8 is a class I member of the histone deacetylases family, although lying phylogenetically close to the evolutionary boundary between class I and class II HDACs. After a comprehensive review of the current understanding of the biology of HDAC8 and its gene, we present recent evidenc indicating that this HDAC is selectively expressed by cells showing smooth muscle cell differentiation, including smooth muscle, myofibro-blastic, and myoepithelial cells. The possible involvement of HDAC8 in the regulation of the smooth muscle cytoskeleton is also presented and discussed.

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Authors and Affiliations

  1. Biologie Générale et Cellulaire, Labo de Recherche sur les Métastases, University of Liège, Liège, Belgium

    David Waltregny MD, PhD & Vincent Castronovo MD, PhD

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  1. David Waltregny MD, PhD
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  2. Vincent Castronovo MD, PhD
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Editors and Affiliations

  1. Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA

    Eric Verdin MD

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© 2006 Humana Press Inc., Totowa, NJ

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Waltregny, D., Castronovo, V. (2006). The Biology of HDAC8, a Unique Class I Histone Deacetylase. In: Verdin, E. (eds) Histone Deacetylases. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1385/1-59745-024-3:87

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