Antibody Therapy for Solid Tumors

  • Cristina I. Truica
  • Dorinda Rouch
  • Carlos L. Arteaga
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

Over the last several years the use of monoclonal antibody (MAb) therapy for the treatment of human malignancy has advanced from experimental therapy to standard of care for some malignancies. The success of MAb therapy stems not only from the ability to humanize the antibody, thus, decreasing the inherent immunogenicity of the approach but also from targeting appropriate proteins. Human cancers associated with the overexpression of particular growth factor receptors such as HER-2/neu, epidermal growth factor receptor, and vascular endothelial growth factor, have been impacted by commercially available antibodies. This review focuses on the mechanisms of action and clinical benefit of MAb therapy against common growth factor receptors.

Key Words

Monoclonal antibody EGFR HER-2/neu VEGF growth factor receptors 

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Copyright information

© Humana Press Inc., Totowa, NJ 2006

Authors and Affiliations

  • Cristina I. Truica
    • 1
  • Dorinda Rouch
    • 1
  • Carlos L. Arteaga
    • 1
  1. 1.Departments of Medicine and Cancer Biology and Breast Cancer Program, Vanderbilt-Ingram Comprehensive Cancer CenterVanderbilt University School of MedicineNashville

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