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Lymphocytic Choriomeningitis Virus

  • Kevin A. Cassady
Part of the Infectious Disease book series (ID)

Abstract

There has been an upsurge of interest in lymphocytic choriomeningitis virus (LCMV) as a human pathogen and specifically as an underdiagnosed congenital infection (1,2). LCMV is a member of the Arenaviridae family of viruses. Arenaviruses have a complex life cycle involving chronic infection and shedding of the virus in rodents and episodic infections in humans (3,4). Six of the arenaviruses (Lassa, Junin, Machupo, Guanarito, Sabia, and Whiteater Arroyo virus) produce an acute and highly fatal hemmorhagic disease in humans (mortality rates 15–30%) (4). LCMV, unlike the arenoviral hemorrhagic fever viruses, produces a flulike illness and aseptic meningitis with a mortality rate of less than 1% in infected adults (2).

Keywords

Central Nervous System Disease Aseptic Meningitis Rift Valley Fever Rift Valley Fever Virus Yellow Fever Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Wright R, Johnson D, Neumann M, et al. Congenital lymphocytic choriomeningitis virus syndrome: a disease that mimics congenital toxoplasmosis or cytomegalovirus infection. Pediatrics 1997;100:E9.PubMedCrossRefGoogle Scholar
  2. 2.
    Barton LL, Mets MB. Congenital lymphocytic choriomeningitis virus infection: decade of rediscovery. Clin Infect Dis 2001;33:370–374.PubMedCrossRefGoogle Scholar
  3. 3.
    Ciurea A, Klenerman P, Hunziker L, et al. Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice. Proc Natl Acad Sci U S A 1999;96:11,964–11,969.PubMedCrossRefGoogle Scholar
  4. 4.
    Buchmeier MJ, Bowden MD, Peters CJ. Arenaviridae: the viruses and their replication. In: Fields BN, Knipe DM, Howley PM, et al., eds. Fields Virology, Vol. 2. Philadelphia: Lippincott, Williams, Wilkins, 2001:1635–1668.Google Scholar
  5. 5.
    el Karamany RM, Imam IZ. Antibodies to lymphocytic choriomeningitis virus in wild rodent sera in Egypt. J Hyg Epidemiol Microbiol Immunol 1991;35:97–103.PubMedGoogle Scholar
  6. 6.
    Morita C, Matsuura Y, Kawashima E, et al. Seroepidemiological survey of lymphocytic choriomeningitis virus in wild house mouse (Mus musculus) in Yokohama Port, Japan. J Vet Med Sci 1991;53:219–222.PubMedGoogle Scholar
  7. 7.
    Childs JE, Glass GE, Korch GW, Ksiazek TG, Leduc JW. Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore. Am J Trop Med Hyg 1992;47:27–34.PubMedGoogle Scholar
  8. 8.
    Lledo L, Gegundez MI, Saz JV, Bahamontes N, Beltran M. Lymphocytic choriomeningitis virus infection in a province of Spain: analysis of sera from the general population and wild rodents. J Med Virol 2003;70:273–275.PubMedCrossRefGoogle Scholar
  9. 9.
    Komrower GM, Williams BL, Stones PB. Lymphocytic choriomeningitis in the newborn; probable transplacental infection. Lancet 1955;268:697–698.PubMedCrossRefGoogle Scholar
  10. 10.
    Stephensen CB, Blount SR, Lanford RE, et al. Prevalence of serum antibodies against lymphocytic choriomeningitis virus in selected populations from two US cities. J Med Virol 1992;38:27–31.PubMedCrossRefGoogle Scholar
  11. 11.
    Park JY, Peters CJ, Rollin PE, et al. Age distribution of lymphocytic choriomeningitis virus serum antibody in Birmingham, Alabama: evidence of a decreased risk of infection. Am J Trop Med Hyg 1997;57:37–41.PubMedGoogle Scholar
  12. 12.
    Dykewicz CA, Dato VM, Fisher-Hoch SP, et al. Lymphocytic choriomeningitis outbreak associated with nude mice in a research institute. JAMA 1992;267:1349–1353.PubMedCrossRefGoogle Scholar
  13. 13.
    Lehmann-Grube F. Portraits of viruses: arenaviruses. Intervirology 1984;22:121–145.PubMedCrossRefGoogle Scholar
  14. 14.
    Mets MB. Childhood blindness and visual loss: an assessment at two institutions including a “new” cause. Trans Am Ophthalmol Soc 1999;97:653–696.PubMedGoogle Scholar
  15. 15.
    del Cerro M, Grover D, Monjan AA, Pfau C, Dematte J. Congenital retinitis in the rat following maternal exposure to lymphocytic choriomeningitis virus. Exp Eye Res 1984;38:313–324.PubMedCrossRefGoogle Scholar
  16. 16.
    Lunkenheimer K, Hufert FT, Schmitz H. Detection of Lassa virus RNA in specimens from patients with Lassa fever by using the polymerase chain reaction. J Clin Microbiol 1990;28:2689–2692.PubMedGoogle Scholar
  17. 17.
    Lozano ME, Ghiringhelli PD, Romanowski V, Grau O. A simple nucleic acid amplification assay for the rapid detection of Junin virus in whole blood samples. Virus Res 1993;27:37–53.PubMedCrossRefGoogle Scholar
  18. 18.
    Demby AH, Chamberlain J, Brown DW, Clegg CS. Early diagnosis of Lassa fever by reverse transcription-PCR. J Clin Microbiol 1994;32:2898–2903.PubMedGoogle Scholar
  19. 19.
    Park JY, Peters CJ, Rollin PE, et al. Development of a reverse transcription-polymerase chain reaction assay for diagnosis of lymphocytic choriomeningitis virus infection and its use in a prospective surveillance study. J Med Virol 1997;51:107–114.PubMedCrossRefGoogle Scholar
  20. 20.
    Enders G, Varho-Gobel M, Lohler J, Terletskaia-Ladwig E, Eggers M. Congenital lymphocytic choriomeningitis virus infection: an underdiagnosed disease. Pediatr Infect Dis J 1999;18:652–655.PubMedCrossRefGoogle Scholar
  21. 21.
    Drosten C, Gottig S, Schilling S, et al. Rapid detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-PCR. J Clin Microbiol 2002;40:2323–2330.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc., Totowa, NJ 2006

Authors and Affiliations

  • Kevin A. Cassady
    • 1
  1. 1.Division of Infectious Diseases, Department of PediatricsUniversity of Alabama at BirminghamBirmingham

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