Lymphocytic Choriomeningitis Virus

  • Kevin A. Cassady
Part of the Infectious Disease book series (ID)


There has been an upsurge of interest in lymphocytic choriomeningitis virus (LCMV) as a human pathogen and specifically as an underdiagnosed congenital infection (1,2). LCMV is a member of the Arenaviridae family of viruses. Arenaviruses have a complex life cycle involving chronic infection and shedding of the virus in rodents and episodic infections in humans (3,4). Six of the arenaviruses (Lassa, Junin, Machupo, Guanarito, Sabia, and Whiteater Arroyo virus) produce an acute and highly fatal hemmorhagic disease in humans (mortality rates 15–30%) (4). LCMV, unlike the arenoviral hemorrhagic fever viruses, produces a flulike illness and aseptic meningitis with a mortality rate of less than 1% in infected adults (2).


Central Nervous System Disease Aseptic Meningitis Rift Valley Fever Rift Valley Fever Virus Yellow Fever Virus 
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Copyright information

© Humana Press Inc., Totowa, NJ 2006

Authors and Affiliations

  • Kevin A. Cassady
    • 1
  1. 1.Division of Infectious Diseases, Department of PediatricsUniversity of Alabama at BirminghamBirmingham

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