Abstract
Eating disorders and obesity are multifactorial disease conditions with several accompanying comorbidities, including a shortened life span. Entangled among their risk factors and within their intricate pathogenesis is mental stress. This power of the mind has been repeatedly shown to affect somatic illnesses, most commonly coronary artery disease (Iso et al., 2002; Krantz, Shaps, Carrey, & Natelson, 2000; Sheps et al., 2002), so mental stress may convincingly result in physical harm. The center of appetite regulation is in close proximity to areas that control the stress response in the hypothalamus, hence the connection between feeding regulation and stress seems not to be by chance. It should be noted that the topic is broad, and the interrelationships within and between biological, psychological, and social factors are complex. This chapter will present several key issues regarding the role of stress in the pathogenesis and etiology of eating disorders, chiefly anorexia nervosa (AN), bulimia nervosa (BN), and obesity.
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References
Alario, P., Gamallo, A., Beato, M. J., & Trancho, G. (1987). Body weight gain, food intake and adrenal development in chronic noise stressed rats. Physiology and Behavior, 40, 29–32.
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders: DSM-IV. Washington, DC: American Psychiatric Association.
Avraham, Y., Bonne, O., & Berry, E. M. (1996). Behavioral and neurochemical alterations caused by diet restriction—the effect of tyrosine administration in mice. Brain Research, 732, 133–144.
Avraham, Y., Hao, S. Z., Mendelson, S., & Berry, E. M. (2001). Tyrosine improves appetite, cognition, and exercise tolerance in activity anorexia. Medicine and Science in Sports and Exercise, 33, 2104–2110.
Avraham, Y., Hao, S., Mendelson, S., Bonne, O., & Berry, E. M. (2001). Diet restriction in mice causes a decrease in hippocampal choline uptake and muscarinic receptors that is restored by administration of tyrosine: Interaction between cholinergic and adrenergic receptors influencing cognitive function. Nutritional Neuroscience, 4, 153–167.
Bale, T. L., Contarino, A. B., Smith, G. W., Chan, R., Gold, L. H., Sawchenko, P. E., Koob, G. F., Vale, W. W., & Lee, K. F. (2000). Mice deficient for corticotropinreleasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nature Genetics, 24, 410–404.
Ball, K., & Lee, C. (2002). Psychological stress, coping, and symptoms of disordered eating in a community sample of young Australian women. International Journal of Eating Disorders, 31, 71–81.
Bjorntorp, P. (2001). Do stress reactions cause abdominal obesity and comorbidities? Obesity Reviews, 2, 73–86.
Burrows, A., & Cooper, M. (2002). Possible risk factors in the development of eating disorders in overweight pre-adolescent girls. International Journal of Obesity and Relatated Metabolic Disorders, 26, 1268–1273.
Canetti, L., Bachar, E., & Berry, E. M. (2002). Food and emotion. Behavioural Processes, 60, 157–164.
Chaki, S., Ogawa, S., Toda, Y., Funakoshi, T., & Okuyama, S. (2003). Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. European Journal of Pharmacology, 474, 95–101.
Ciccocioppo, R., Martin-Fardon, R., Weiss, F., & Massi, M. (2001). Nociceptin/orphanin FQ inhibits stress-and CRF-induced anorexia in rats. Neuroreport, 12, 1145–1149.
Connan, F., Campbell, I. C., Katzman, M., Lightman, S. L., & Treasure, J. (2003). A neurodevelopmental model for anorexia nervosa. Physiology and Behavior, 79, 13–24.
Crowther, J. H., Sanftner, J., Bonifazi, D. Z., & Sheperd, K. L. (2001). The role of daily hassles in binge eating. International Journal of Eating Disorders, 29, 449–454.
Dallman, M. F., Pecoraro, N., Akana, S. F., La Fleur, S. E., Gomez, F., Houshyar, H., Bell, M. E., Bhatnagar, S., Laugero, K. D., & Manalo, S. (2003). Chronic stress and obesity: A new view of “comfort food”. Proceedings of the National Academy of Sciences of the United States of America, 100, 11,696–11,701.
Di Marzo, V., Goparaju, S. K., Wang, L., Liu, J., Batkai, S., Jarai, Z., Fezza, F., Miura, G. I., Palmiter, R. D., Sugiura, T., & Kunos, G. (2001). Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature, 410, 822–825.
Drapeau, V., Therrien, F., Richard, D., & Tremblay, A. (2003). Is visceral obesity a physiological adaptation to stress? Panminerva Medica, 45, 189–195.
Epel, E., Lapidus, R., McEwen, B., & Brownell, K. (2001). Stress may add bite to appetite in women: A laboratory study of stress-induced cortisol and eating behavior. Psychoneuroendocrinology, 26, 37–49.
Fairburn, C. G., Doll, H. A., Welch, S. L., Hay, P. J., Davies, B. A., & O’Connor, M. E. (1998). Risk factors for binge eating disorder: A community-based, case-control study. Archives of General Psychiatry, 55, 425–432.
Fairburn, C. G., & Harrison, P. J. (2003). Eating disorders. Lancet, 361, 407–416.
Fairburn, C. G., Welch, S. L., Doll, H. A., Davies, B. A., & O’Connor, M. E. (1997). Risk factors for bulimia nervosa. A community-based case-control study. Archives of General Psychiatry, 54, 509–517.
Fetissov, S. O., Hallman, J., Oreland, L., Af Klinteberg, B., Grenback, E., Hulting, A. L., & Hokfelt, T. (2002). Autoantibodies against alpha-MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients. Proceedings of the National Academy of Sciences of the United States of America, 99, 17,155–17,160.
Fryer, S., Waller, G., & Kroese, B. S. (1997). Stress, coping, and disturbed eating attitudes in teenage girls. International Journal of Eating Disorders, 22, 427–436.
Glowa, J. R., & Gold, P. W. (1991). Corticotropin releasing hormone produces profound anorexigenic effects in the rhesus monkey. Neuropeptides, 18, 55–61.
Hagan, M. M., Chandler, P. C., Wauford, P. K., Rybak, R. J., & Oswald, K. D. (2003). The role of palatable food and hunger as trigger factors in an animal model of stress induced binge eating. International Journal of Eating Disorders, 34, 183–197.
Hagan, M.M., Wauford, P.K., Chandler, P.C., Jarrett, L.A., Rybak, R.J., & Blackburn, K. (2002). A new animal model of binge eating: Key synergistic role of past caloric restriction and stress. Physiology and Behavior, 77, 45–54.
Hao, S. Z., Avraham, Y., Bonne, O., & Berry, E. M. (2001). Separation-induced body weight loss, impairment in alternation behavior, and autonomic tone: Effects of tyrosine. Pharmacology, Biochemistry, and Behavior, 68, 273–281.
Horesh, N., Apter, A., Lepkifker, E., Ratzoni, G., Weizmann, R., & Tyano, S. (1995). Life events and severe anorexia nervosa in adolescence. Acta Psychiatrica Scandinavica, 9, 15–19.
Iso, H., Date, C., Yamamoto, A., Toyoshima, H., Tanabe, N., Kikuchi, S., Kondo, T., Watanabe, Y., Wada, Y., Ishibashi, T., Suzuki, H., Koizumi, A., Inaba, Y., Tamakoshi, A., & Ohno, Y. (2002). Perceived mental stress and mortality from cardiovascular disease among Japanese men and women: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study). Circulation, 106, 1229–1236.
Krantz, D. S., Sheps, D. S., Carney, R. M., & Natelson, B. H. (2000). Effects of mental stress in patients with coronary artery disease: Evidence and clinical implications. Journal of the American Medical Association, 283, 1800–1802.
Krebs, H., Weyers, P., Macht, M., Weijers, H. G., & Janke, W. (1997). Scanning behavior of rats during eating under stressful noise. Physiology and Behavior, 62, 151–154.
Laitinen, J., Ek, E., & Sovio, U. (2002). Stress-related eating and drinking behavior and body mass index and predictors of this behavior. Preventive Medicine, 3, 429–439.
Marti, O., Marti, J., & Armario, A. (1994). Effects of chronic stress on food intake in rats: Influence of stressor intensity and duration of daily exposure. Physiology and Behavior, 55, 747–753.
Oliver, G., & Wardle, J. (1999). Perceived effects of stress on food choice. Physiology and Behavior, 66, 511–515.
Oliver, G., Wardle, J., & Gibson, E. L. (2000). Stress and food choice: A laboratory study. Psychosomatic Medicine, 62, 853–865.
Oohara, M., Negishi, M., Shimizu, H., Sato, N., & Mori, M. (1993). Alpha-melanocyte stimulating hormone (MSH) antagonizes the anorexia by corticotropin releasing factor (CRF). Life Sciences, 53, 1473–1477.
Patton, G. C., Johnson-Sabine, E., Wood, K., Mann, A. H., & Wakeling, A. (1990). Abnormal eating attitudes in London schoolgirls—a prospective epidemiological study: Outcome at twelve month follow-up. Psychological Medicine, 20, 383–394.
Perez, M., Voelz, Z. R., Pettit, J. W., & Joiner, T. E., Jr. (2002). The role of acculturative stress and body dissatisfaction in predicting bulimic symptomatology across ethnic groups. International Journal of Eating Disorders, 31, 442–454.
Rosen, J. C., Compas, B. E., & Tacy, B. (1993). The relation among stress, psychological symptoms, and eating disorder symptoms: A prospective analysis. International Journal of Eating Disorders, 14, 153–162.
Rosmond, R. (2003). Stress induced disturbances of the HPA axis: A pathway to Type 2 diabetes? Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 9, RA35–39.
Rosmond, R., Dallman, M. F., & Bjorntorp, P. (1998). Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. The Journal of Clinical Endocrinology and Metabolism, 83, 1853–1859.
Schmidt, U., Tiller, J., Blanchard, M., Andrews, B., & Treasure, J. (1997). Is there a specific trauma precipitating anorexia nervosa? Psychological Medicine, 27, 523–530.
Sheps, D. S., McMahon, R. P., Becker, L., Carney, R. M., Freedland, K. E., Cohen, J. D., Sheffield, D., Goldberg, A. D., Ketterer, M. W., Pepine, C. J., Raczynski, J. M., Light, K., Krantz, D. S., Stone, P. H., Knatterud, G. L., & Kaufmann, P. G. (2002). Mental stress-induced ischemia and all-cause mortality in patients with coronary artery disease: Results from the Psychophysiological Investigations of Myocardial Ischemia study. Circulation, 105, 1780–1784.
Siegfried, Z., Berry, E. M., Hao, S., & Avraham, Y. (2003). Animal models in the investigation of anorexia. Physiology and Behavior, 79, 39–45.
Siegfried, Z., Kanyas, K., Latzer, Y., Karni, O., Bloch, M., Lerer, B., & Berry, E. M. (2004). Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa: Differences between restricting and binging/purging subtypes. American Journal of Medical Genetics, 125B, 126–130.
Slade, P. (1982). Towards a functional analysis of anorexia nervosa and bulimia nervosa. British Journal of Clinical Psychology, 21(Pt. 3), 167–179.
Tamashiro, K. L., Nguyen, M. M., Fujikawa, T., Xu, T., Yun Ma, L., Woods, S. C., & Sakai, R. R. (2004). Metabolic and endocrine consequences of social stress in a visible burrow system. Physiology and Behavior, 80, 683–693.
Valles, A., Marti, O., Garcia, A., & Armario, A. (2000). Single exposure to stressors causes long-lasting, stress-dependent reduction of food intake in rats. American Journal of Physiology—Regulatory, Integrative and Comparative Physiology, 279, R1138–1144.
van Leeuwen, S. D., Bonne, O., Avraham, Y., & Berry, E. M. (1997). Separation as a new animal model for self-induced weight loss. Physiology and Behavior, 62, 77–81.
Ward, A., Tiller, J., Treasure, J., & Russell, G. (2000). Eating disorders: Psyche or soma? International Journal of Eating Disorders, 27, 279–287.
Yeomans, M. R., & Gray, R. W. (2002). Opioid peptides and the control of human ingestive behaviour. Neuroscience and Biobehavioral Reviews, 26, 713–728.
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Dubnov, G., Berry, E.M. (2006). Stress in the Pathogenesis of Eating Disorders and Obesity. In: Yehuda, S., Mostofsky, D.I. (eds) Nutrients, Stress, and Medical Disorders. Nutrition and Health. Humana Press. https://doi.org/10.1385/1-59259-952-4:253
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DOI: https://doi.org/10.1385/1-59259-952-4:253
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